ID W2TMW2_NECAM Unreviewed; 501 AA.
AC W2TMW2;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Myosin head {ECO:0000313|EMBL:ETN83440.1};
GN ORFNames=NECAME_01747 {ECO:0000313|EMBL:ETN83440.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN83440.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; KI658196; ETN83440.1; -; Genomic_DNA.
DR RefSeq; XP_013305667.1; XM_013450213.1.
DR AlphaFoldDB; W2TMW2; -.
DR STRING; 51031.W2TMW2; -.
DR EnsemblMetazoa; NECAME_01747; NECAME_01747; NECAME_01747.
DR GeneID; 25341787; -.
DR KEGG; nai:NECAME_01747; -.
DR CTD; 25341787; -.
DR OMA; HYESKES; -.
DR OrthoDB; 1094820at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:InterPro.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF709; UNCONVENTIONAL MYOSIN-XV; 1.
DR Pfam; PF00063; Myosin_head; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676}.
FT DOMAIN 1..501
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 397..419
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 501 AA; 57531 MW; 92B8E50EFEA283EA CRC64;
MSSDTKATYG IRDQQKFFYL TQGKVGENIR DDALNFPRLD GSLEILGFSE EQRQIIYKTL
ATILHLGNMY FRQRRNAEDE AEYVEVSNDV ELKWASYLLD VDMFSFAPCF THKIIKTDEG
VSKTAFSMGQ ALDARDALAM TLYEVVFSWI LNRISLHLKC SDHNAVISVI DYYGVERYIN
NGLEQLLINS VNEKLENAFL KQTFLDEMAD YTEEGLTFEW KTLLACKGSQ PHHESFGICE
IYIDWHFYSK YFVLIHKRGP GIPRIMPASL DNEKVLDLLC KKPYGLLYLI DDECKFPKAS
DESYLRHCNL NHLDKNVYGK AKNKERLQMS VRHSFGSTWY TVHGFVQRNK RALPGNVVKI
LADSQNTVIS MLFRPLAGTK EGNDYVVYAG QQFNTASTAL VEKIVSSQSH FVRCVRSNNE
RIPARLDETS LARQLKALSI IETLHFRQAG FPVRIPFERF ARNYRCLLPS DIALCQKQKE
IIVDILDGQG VKFADDYQIG L
//
