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Database: UniProt
Entry: W2TNE3_NECAM
LinkDB: W2TNE3_NECAM
Original site: W2TNE3_NECAM 
ID   W2TNE3_NECAM            Unreviewed;       786 AA.
AC   W2TNE3;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   03-MAY-2023, entry version 45.
DE   RecName: Full=Metalloendopeptidase {ECO:0000256|RuleBase:RU361183};
DE            EC=3.4.24.- {ECO:0000256|RuleBase:RU361183};
DE   Flags: Fragment;
GN   ORFNames=NECAME_17402 {ECO:0000313|EMBL:ETN83625.1};
OS   Necator americanus (Human hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC   Ancylostomatoidea; Ancylostomatidae; Bunostominae; Necator.
OX   NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN83625.1, ECO:0000313|Proteomes:UP000053676};
RN   [1] {ECO:0000313|Proteomes:UP000053676}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24441737; DOI=10.1038/ng.2875;
RA   Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA   Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA   Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA   Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA   Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT   "Genome of the human hookworm Necator americanus.";
RL   Nat. Genet. 46:261-269(2014).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|PROSITE-ProRule:PRU01211,
CC         ECO:0000256|RuleBase:RU361183};
CC       Note=Binds 1 zinc ion per subunit. {ECO:0000256|PROSITE-
CC       ProRule:PRU01211, ECO:0000256|RuleBase:RU361183};
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01211}.
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DR   EMBL; KI658151; ETN83625.1; -; Genomic_DNA.
DR   RefSeq; XP_013305852.1; XM_013450398.1.
DR   AlphaFoldDB; W2TNE3; -.
DR   MEROPS; M12.310; -.
DR   EnsemblMetazoa; NECAME_17402; NECAME_17402; NECAME_17402.
DR   GeneID; 25357428; -.
DR   KEGG; nai:NECAME_17402; -.
DR   CTD; 25357428; -.
DR   OMA; CIRFRHA; -.
DR   OrthoDB; 2879203at2759; -.
DR   Proteomes; UP000053676; Unassembled WGS sequence.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 3.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001506; Peptidase_M12A.
DR   InterPro; IPR006026; Peptidase_Metallo.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   PANTHER; PTHR10127; DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING; 1.
DR   PANTHER; PTHR10127:SF820; ZINC METALLOPROTEINASE NAS-31; 1.
DR   Pfam; PF01400; Astacin; 2.
DR   PRINTS; PR00480; ASTACIN.
DR   SMART; SM00235; ZnMc; 2.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 2.
DR   SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR   PROSITE; PS51864; ASTACIN; 2.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01211,
KW   ECO:0000256|RuleBase:RU361183};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU01211,
KW   ECO:0000256|RuleBase:RU361183};
KW   Metalloprotease {ECO:0000256|PROSITE-ProRule:PRU01211,
KW   ECO:0000256|RuleBase:RU361183};
KW   Protease {ECO:0000256|PROSITE-ProRule:PRU01211,
KW   ECO:0000256|RuleBase:RU361183};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU01211, ECO:0000256|RuleBase:RU361183}.
FT   DOMAIN          98..267
FT                   /note="Peptidase M12A"
FT                   /evidence="ECO:0000259|PROSITE:PS51864"
FT   DOMAIN          558..674
FT                   /note="Peptidase M12A"
FT                   /evidence="ECO:0000259|PROSITE:PS51864"
FT   ACT_SITE        191
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01211"
FT   ACT_SITE        579
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01211"
FT   BINDING         190
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01211"
FT   BINDING         194
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01211"
FT   BINDING         200
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01211"
FT   BINDING         578
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01211"
FT   BINDING         582
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01211"
FT   BINDING         588
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01211"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ETN83625.1"
SQ   SEQUENCE   786 AA;  89142 MW;  BEC5BBC6392EB864 CRC64;
     ALNTTTLQRV HEKFKKFGEK LKAKLTLSPE QKARLQELLK KIVPIKKDHV QKDGDSIEEI
     NTKKKIGEFL FQSDIVLTEE QANEIVDVDN SGNRTKRQAF RDGNYPRTIW STGVNFFFDP
     SAGPDIQRIF KKGAALWQKD TCIDFRMDNT APNRVRVFRE DGCWSFVGNL NRQQDLSLGK
     GCETVAIAAH EIGHALGFFH TQSRHDRDDF IVFNPQNVKV ILDPLPSSSV NGGITMMPRD
     PRYTETLGSP FISFYELLML NAHYRCLERC DKATSAKCMM GGFPHPRDCS RCVCPSGYGG
     RLCNERPPGC GGTLEAKPQY QVLLDEVGDT KAGKQAREDM TTCTYWIKAP VGSRIEVKIA
     DLSRGLAVDG CSYWGVEIKT HADQRLTGYR FCAPEDVGVT LVSKFHVVPI ITYNRFYATQ
     VKLQYRIDSP PCTAIITIIT FLMIVIIAYQ LLPINLSVQL HSEDEHPQQP LNAVNTTALE
     RIHEKFQHLG EKFMVDITLS SEQRLNNLLK MLNKGDRTKR QAFRDHRYPR TLWSTGVNYF
     FDPRTDPDIR RIFQKGAELW EKDTCIDFRM NNTATAAHEI GHALGFFHTQ SRHDRDDFIT
     FNARNVKRSW MDQFTKETTR TNENYGITYD YGSIMHYGST GCICPSGYGG RLCNEKPPGC
     GSVLEAKSGY KTLSDKVGDF REGLRPGEDM TTCSYWIKAP VGLRIEVKIA DLSSGLAVDG
     CTYWGVEIKT HTDQRLTGYR FCSPEDIGVT LVSNYHIVPI ITYNLRNSIQ ITISYRYVLI
     NSIVIS
//
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