ID W2TNT0_NECAM Unreviewed; 1106 AA.
AC W2TNT0;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Sec23/Sec24 trunk domain protein {ECO:0000313|EMBL:ETN83329.1};
GN ORFNames=NECAME_07447 {ECO:0000313|EMBL:ETN83329.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN83329.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle
CC membrane {ECO:0000256|ARBA:ARBA00004299}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004299}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004299}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004397}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; KI658235; ETN83329.1; -; Genomic_DNA.
DR RefSeq; XP_013305556.1; XM_013450102.1.
DR AlphaFoldDB; W2TNT0; -.
DR STRING; 51031.W2TNT0; -.
DR EnsemblMetazoa; NECAME_07447; NECAME_07447; NECAME_07447.
DR GeneID; 25347477; -.
DR KEGG; nai:NECAME_07447; -.
DR CTD; 25347477; -.
DR OMA; INPFMTF; -.
DR OrthoDB; 977017at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0030127; C:COPII vesicle coat; IEA:InterPro.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd01479; Sec24-like; 1.
DR Gene3D; 2.60.40.1670; beta-sandwich domain of Sec23/24; 2.
DR Gene3D; 1.20.120.730; Sec23/Sec24 helical domain; 1.
DR Gene3D; 3.40.20.10; Severin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR Gene3D; 2.30.30.380; Zn-finger domain of Sec23/24; 1.
DR InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
DR InterPro; IPR007123; Gelsolin-like_dom.
DR InterPro; IPR036180; Gelsolin-like_dom_sf.
DR InterPro; IPR006900; Sec23/24_helical_dom.
DR InterPro; IPR036175; Sec23/24_helical_dom_sf.
DR InterPro; IPR006896; Sec23/24_trunk_dom.
DR InterPro; IPR012990; Sec23_24_beta_S.
DR InterPro; IPR041742; Sec24-like_trunk_dom.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR13803; SEC24-RELATED PROTEIN; 1.
DR PANTHER; PTHR13803:SF4; SECRETORY 24CD, ISOFORM C; 1.
DR Pfam; PF00626; Gelsolin; 1.
DR Pfam; PF08033; Sec23_BS; 1.
DR Pfam; PF04815; Sec23_helical; 1.
DR Pfam; PF04811; Sec23_trunk; 1.
DR SUPFAM; SSF81995; beta-sandwich domain of Sec23/24; 1.
DR SUPFAM; SSF82754; C-terminal, gelsolin-like domain of Sec23/24; 1.
DR SUPFAM; SSF81811; Helical domain of Sec23/24; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676}.
FT DOMAIN 510..751
FT /note="Sec23/Sec24 trunk"
FT /evidence="ECO:0000259|Pfam:PF04811"
FT DOMAIN 757..840
FT /note="Sec23/Sec24 beta-sandwich"
FT /evidence="ECO:0000259|Pfam:PF08033"
FT DOMAIN 851..952
FT /note="Sec23/Sec24 helical"
FT /evidence="ECO:0000259|Pfam:PF04815"
FT DOMAIN 979..1038
FT /note="Gelsolin-like"
FT /evidence="ECO:0000259|Pfam:PF00626"
FT REGION 1..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 148..176
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..230
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..323
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1106 AA; 119180 MW; B46A448535A9CD58 CRC64;
MFAPPFPPTN GGGPGAQPQA TYPAPNMATG GAPPPAIGGF PKPSMDASRG YPGMPPHPAN
GPQMPAATSA QSPMVPFPAP VSTSAHQPST FPSVVNGFHS AVQPPSQPPL QHAGAPTTSY
QPVQPPSSVA NFPSSHHPYG VSQSNGPIPT PTGPPQPTHM TQNQPLPIPP NYSAGPQQNA
PIPGYPQTTS HQLNSAGVLN TTVPAPSQQQ RQPQLGPSGA PPPPSFPSSV PSHASPGFPV
HGGAMPSFPQ PGFAHSSAPS GPPGHPMMGS QPSFGPPGGM PLGASAMPPG APMAVGFPPV
PGGPPTGFPG APGMQPRQPQ PQPQQRLDPN MMPSAVEVME IDSAQAGQFP TGYPHANPPP
LVSTDFYAVD QGNCSPRLMR STIYMAPASN DLLKAAQIPF AVAISPFAAL HSQEGPEAPL
GVSVAKLICV LSWSSKMEEG DSAVHFVTPP LLFFFPHNID VNSCLLVEDV YFAHLDHTGR
RTDIDHRPEL FLGAYEFIAT KQYCKNGLPP KEPAFIFMID VSYNAVQNGM LQVVCSNLEK
LLSRLPKELG ASESVIHVGL ATFDQVVHFF DLSAAQPSMM VVGDVGDMFV PIVDGLLLPY
SQAAPSIRAV LAEIPRLFAP TKITETILGP VVQAGLDALQ CADRAGKVFI FSTSLPSLEA
PGKLKARNER NLLGTDKEKT ALTPQGEFYS KLGEQCVKAG VTVDLFLFPN SFMDVASIAQ
LSAVTGGNVY KYQYFVADKD ASRFLADLDH DISRQIAFDC MARVRSSAGI RPVLFQGSFY
MENSTDLEMA SIDEDKSFFA ELKHDDKLSD QNAIIQCAVL FTSVSGQRRL RILNICLPVS
SDYNQLYRVA DQGALVSYLL KNAVQANREK GNKEMKEQIF QRCAQILATY REKVSESAPL
GQLILPETLK LLPLFVNSIV KNDSINGGSE MTVDDKVWMI ELIRGMRVDH AMLLLYPKIV
PVDHLELHDP SELTNVTGSI RASYENLVHS KAYLIDNGIV LFLWIGLGVA EAWVQDIFGV
NNVAMLDTEN AQIPEKDNAR SRGLRRAVEL LQEVGPRKRK LFVVREKDAL EPWMKKFLVE
DRSGPNVMSY VDFLCYIHRE IRNILS
//
