ID W2TPM4_NECAM Unreviewed; 283 AA.
AC W2TPM4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Nematode cuticle collagen domain protein {ECO:0000313|EMBL:ETN83086.1};
GN ORFNames=NECAME_01886 {ECO:0000313|EMBL:ETN83086.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN83086.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
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DR EMBL; KI658313; ETN83086.1; -; Genomic_DNA.
DR RefSeq; XP_013305313.1; XM_013449859.1.
DR AlphaFoldDB; W2TPM4; -.
DR STRING; 51031.W2TPM4; -.
DR EnsemblMetazoa; NECAME_01886; NECAME_01886; NECAME_01886.
DR GeneID; 25341926; -.
DR KEGG; nai:NECAME_01886; -.
DR CTD; 25341926; -.
DR OMA; VFECCSC; -.
DR OrthoDB; 2883462at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0042302; F:structural constituent of cuticle; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR InterPro; IPR002486; Col_cuticle_N.
DR InterPro; IPR008160; Collagen.
DR PANTHER; PTHR24637:SF372; COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24637; COLLAGEN; 1.
DR Pfam; PF01484; Col_cuticle_N; 1.
DR Pfam; PF01391; Collagen; 2.
DR SMART; SM01088; Col_cuticle_N; 1.
PE 4: Predicted;
KW Collagen {ECO:0000313|EMBL:ETN83086.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 16..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..67
FT /note="Nematode cuticle collagen N-terminal"
FT /evidence="ECO:0000259|SMART:SM01088"
FT REGION 98..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 143..157
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..189
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..229
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 283 AA; 28090 MW; 859A17D79FB132F5 CRC64;
MEDKLKLVEA ESVKKFAFFG VAVSTVATLT AIVAVPMLCM YMQNVQSGLQ DEINFCRTRA
EGLRGEYTKI ESFRKVEARE KRQTYQCCSC GMGPAGPVGN PGQDGAPGND GRPGAPGAPG
PDAPNDHIIP RPEDFCFECP PGPAGTPGQP GPKGPPGNAG APGEQGPNGR PGSPGAPGPQ
GPPGPNGNDG QPGQPGAPGQ VRTVPSPPGP PGQPGDPGPQ GPPGPDGRPG NPGTSGSPGA
QGDPGQDGPP GNPGAPGQPG APGKDGLKGS CDHCPPPRTA PGY
//
