ID W2TQ84_NECAM Unreviewed; 68 AA.
AC W2TQ84;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Copper transport protein ATOX1 {ECO:0000256|ARBA:ARBA00040962};
DE AltName: Full=Metal transport protein ATX1 {ECO:0000256|ARBA:ARBA00043201};
GN ORFNames=NECAME_07182 {ECO:0000313|EMBL:ETN83819.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN83819.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- FUNCTION: Binds and deliver cytosolic copper to the copper ATPase
CC proteins. May be important in cellular antioxidant defense.
CC {ECO:0000256|ARBA:ARBA00037651}.
CC -!- SIMILARITY: Belongs to the ATX1 family.
CC {ECO:0000256|ARBA:ARBA00038171}.
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DR EMBL; KI658080; ETN83819.1; -; Genomic_DNA.
DR RefSeq; XP_013306046.1; XM_013450592.1.
DR AlphaFoldDB; W2TQ84; -.
DR STRING; 51031.W2TQ84; -.
DR EnsemblMetazoa; NECAME_07182; NECAME_07182; NECAME_07182.
DR GeneID; 25347212; -.
DR KEGG; nai:NECAME_07182; -.
DR CTD; 25347212; -.
DR OMA; MTHTYKF; -.
DR OrthoDB; 1107952at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006825; P:copper ion transport; IEA:UniProtKB-KW.
DR CDD; cd00371; HMA; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR PANTHER; PTHR46365; COPPER TRANSPORT PROTEIN ATOX1; 1.
DR PANTHER; PTHR46365:SF1; COPPER TRANSPORT PROTEIN ATOX1; 1.
DR Pfam; PF00403; HMA; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 3: Inferred from homology;
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Copper transport {ECO:0000256|ARBA:ARBA00022796};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 1..66
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
SQ SEQUENCE 68 AA; 7413 MW; C6BC6BA1D59BE2F9 CRC64;
MPQYTFEMAM TCDGCANAAR RVLGKLGEDK VTIEKIDVGT KQVVVTTDLP ASDILEALKK
TGKEIKQL
//
