ID   W2TRA1_NECAM            Unreviewed;       995 AA.
AC   W2TRA1;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=Pre-mRNA-processing factor 6 {ECO:0000256|ARBA:ARBA00020235};
DE   AltName: Full=PRP6 homolog {ECO:0000256|ARBA:ARBA00032140};
DE   AltName: Full=U5 snRNP-associated 102 kDa protein {ECO:0000256|ARBA:ARBA00031070};
GN   ORFNames=NECAME_17215 {ECO:0000313|EMBL:ETN84199.1};
OS   Necator americanus (Human hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC   Necator.
OX   NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN84199.1, ECO:0000313|Proteomes:UP000053676};
RN   [1] {ECO:0000313|Proteomes:UP000053676}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24441737; DOI=10.1038/ng.2875;
RA   Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA   Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA   Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA   Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA   Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT   "Genome of the human hookworm Necator americanus.";
RL   Nat. Genet. 46:261-269(2014).
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DR   EMBL; KI657999; ETN84199.1; -; Genomic_DNA.
DR   RefSeq; XP_013306426.1; XM_013450972.1.
DR   AlphaFoldDB; W2TRA1; -.
DR   STRING; 51031.W2TRA1; -.
DR   EnsemblMetazoa; NECAME_17215; NECAME_17215; NECAME_17215.
DR   GeneID; 25357241; -.
DR   KEGG; nai:NECAME_17215; -.
DR   CTD; 25357241; -.
DR   OMA; DGWAWYY; -.
DR   OrthoDB; 655233at2759; -.
DR   Proteomes; UP000053676; Unassembled WGS sequence.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR   InterPro; IPR003107; HAT.
DR   InterPro; IPR010491; PRP1_N.
DR   InterPro; IPR045075; Syf1-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR11246; PRE-MRNA SPLICING FACTOR; 1.
DR   PANTHER; PTHR11246:SF1; PRE-MRNA-PROCESSING FACTOR 6; 1.
DR   Pfam; PF06424; PRP1_N; 1.
DR   Pfam; PF14559; TPR_19; 2.
DR   SMART; SM00386; HAT; 11.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF48452; TPR-like; 3.
DR   PROSITE; PS50005; TPR; 2.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   DOMAIN          22..173
FT                   /note="PRP1 splicing factor N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF06424"
FT   REPEAT          718..751
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          895..928
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REGION          33..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          125..152
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        60..76
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   995 AA;  112668 MW;  BFA4BB633A16943C CRC64;
     MSITIPGSLV NKTKKHFMGM PAPAGYVPGV GRGATGFTTR SDIGPAREAT DVPETGTGPP
     SKKPKEEAAK EDNEESLNDN NYDEFEGYAG SLFAKDPYDK EDEEADEVYL AVETRIDERR
     KDYREKKYKE AIEKYRKERP KIQQEFSDLK RQLSEVTEDE WVAIPEVGDS RNKAKRNPRT
     EKFTPVPDSV IAMSMNYGET TSMLDSRVQS GMTTPFGSGF QSTFGGGWKT GISSGISTGH
     DLDLIKIGQA RNKIMDIKLN QVSDSVTGQT VVDPKGYLTD LQSMIPQYGG DINDVKKARF
     HSARMLLKSV RETNPKHPPA WIASARLEEV VGKLQVARHL IMEGCEKNKR SEDIWLEAVR
     LHPPETAKAI VANAVRAMPH SVRIWMKAAD IETDMKAKKK VFRKALEQIP TSVRLWKAAI
     ELEEPDDARV LLTRAVECCS SSTELWLALA RLETYENARK VLNKAREHIP TDRQIWLCAA
     RLEETRGQKD MVDRIVQKAL TSLTANMVEL NREHWMKDAV DAEKAGCTLT CQAIIRHVIG
     AGVEDEDKKA TWLEDADSFA KQGALACARA VYVHALKNVE KRKGIWLATA HFEKTHGTIE
     EYEAVLADAT ASCPQVEVLW LMYAKSRWLH GDVAGAREIL AKAFEHNANS EGIWMAAVKL
     ESENNEFARA RRLLDKARRN APSARIWMKS ARLEWCLGDL DRAKELIKEG MEKYPDFAKF
     YMMLGQIYLQ ENSYDEARKI ITEGIKKCPG AIPLWLLLSR LEESQKQIIK ARSDLEKKLP
     EIISWEGSVG VTSSALTSTD IRDASYTLSF SHHCEEIKNL FHARIRNPRN EDLWLESVRL
     EMRAGLRDLA SERLARALQE CEGSGRLWAE AIWMEERHGR RAKSVDALKR CEHNPHVLIA
     AARLFWAERK VKKAREWFQR AINVDPDNGD AYAQIYKFEL MLGSDEEQEK VLKKCEEAEP
     RHGELWVTVS KDPKHWRKKT GEILKTVVAS IPIPS
//