ID W2TSC1_NECAM Unreviewed; 457 AA.
AC W2TSC1;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=7 transmembrane receptor {ECO:0000313|EMBL:ETN83907.1};
GN ORFNames=NECAME_01700 {ECO:0000313|EMBL:ETN83907.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN83907.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; KI658066; ETN83907.1; -; Genomic_DNA.
DR RefSeq; XP_013306134.1; XM_013450680.1.
DR AlphaFoldDB; W2TSC1; -.
DR STRING; 51031.W2TSC1; -.
DR EnsemblMetazoa; NECAME_01700; NECAME_01700; NECAME_01700.
DR GeneID; 25341740; -.
DR KEGG; nai:NECAME_01700; -.
DR CTD; 25341740; -.
DR OMA; TATHPCF; -.
DR OrthoDB; 4815971at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR24241:SF59; ADIPOKINETIC HORMONE RECEPTOR, ISOFORM C; 1.
DR PANTHER; PTHR24241; NEUROPEPTIDE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688, ECO:0000313|EMBL:ETN83907.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 18..44
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..365
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 35..362
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 457 AA; 52059 MW; BD21792A2800580B CRC64;
MLNCSLIPPP DLTVTSSILS IVLCYIIVFI IAFIGNFTMF LILCRNQWIK VRRVHSLLLQ
MNIAHLMVTL FYMPKEILHN YTIAWYGGDV LCRTCKFFDV FGIALSMNIL ICISLDRFYS
IFFPLYAMRA RKSVQKMVIV AWITSFATSA PQFYLFKTAT HPCFPTYTQC VSRNLVNEIS
TDVGLIFVRM NVDITKSSKN DRAEAASDAL LRRSGVNTLE RARSRTLRLL AIVFLVVFYF
SILNIVQVYF FPLIVTVVCY SLILWKISEE SSAKKKETEA ASDALLRRSG VNTLERARSR
TLSMFCFRMT FVIVVAFICC WTPYAIMMFL HFLTKTDWIP KDVRKFIYAF AVFNSAISPY
LYGYFSFDVK KELKLLLTCS RNTASDRHLS CSANVVRSNT SQRIRKRSAS ATQLVPGSQE
PVTPVLSSRG HSLRTAKKPC LITTSATTLS PQTAIRI
//
