ID W2TSX5_NECAM Unreviewed; 747 AA.
AC W2TSX5;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=PQQ enzyme repeat protein {ECO:0000313|EMBL:ETN84858.1};
GN ORFNames=NECAME_06662 {ECO:0000313|EMBL:ETN84858.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN84858.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
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DR EMBL; KI657850; ETN84858.1; -; Genomic_DNA.
DR RefSeq; XP_013307085.1; XM_013451631.1.
DR AlphaFoldDB; W2TSX5; -.
DR STRING; 51031.W2TSX5; -.
DR EnsemblMetazoa; NECAME_06662; NECAME_06662; NECAME_06662.
DR GeneID; 25346694; -.
DR KEGG; nai:NECAME_06662; -.
DR CTD; 25346694; -.
DR OMA; ELFMAFH; -.
DR OrthoDB; 76882at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR002372; PQQ_repeat.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR44394; BETA-ALANINE-ACTIVATING ENZYME; 1.
DR PANTHER; PTHR44394:SF1; BETA-ALANINE-ACTIVATING ENZYME; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13360; PQQ_2; 1.
DR SMART; SM00564; PQQ; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053676}.
FT DOMAIN 98..235
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
SQ SEQUENCE 747 AA; 82773 MW; 69BE89924EBE41F1 CRC64;
MITVPFSIHE LCDSGEERLL SCNDVCEKVA SFKEVFRGID AKLVALHMPR SSELVCAVAA
LVDIHTPFLI LQPGDNPVSL RAHFLFDGKE LVEINSLHEC TSDEAEEQDF CYFISTSGTT
GSAKLVGVPY SCIGPNIEDF SERFSITSDD LVLCSTSFCF DPSIVELFLT FTSGAQLLLV
PDRIRSQPHL FSNVLKTYTP TFVQLTPSVL SLFDESTLSW IFSDHSLIRC LLIGGTRRCR
VNGVWGGEFT ATGDIVDVVD GKYVVVGRTD DQIKLNGIRC NLAALSEIVH TLRGVFFAYF
LLYRDKFLVL FVKSETAIEG SLQQIMSSSF IPSKVIYLDR VPLTPSGKVD RLKLTLMLEE
QCSAQMKSWS DIFKFLEKFG IRHTPDLSFQ SFVNYGSKRI GCSDVVIDVS VILSLQPDIS
WACDTKKCID GTPLLTKLFD EDVVAACSHS GVVVCLRLRD GFCLWKTRIH CRFETSPTRT
GDYIVVGGYD GGVYFLSANT GVTEWRFGCG DAVKATCAID TSDNVYVPAY DRKLYKLDPK
QRECVWSCPI RSGSPARAVV LKECVFVTTI KGSLEAINMD RGMLLWLYQT QAPIFSSLAI
FCESGFISSV DGVVTKIRLN DGKKEVAANT HEPIFARVSI FCNLVHIVTQ SGSLFLADLM
LHILRSFRFA SCSFVVPPRT VRDNAVGLVS SSGLFIIFNK DNGEAHAFRL GAGQVFSSVV
VSYETNCMIA GCRDDWLRCF KLPVGFL
//
