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Database: UniProt
Entry: W2TT68_NECAM
LinkDB: W2TT68_NECAM
Original site: W2TT68_NECAM 
ID   W2TT68_NECAM            Unreviewed;       278 AA.
AC   W2TT68;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   RecName: Full=deoxyribose-phosphate aldolase {ECO:0000256|ARBA:ARBA00012515};
DE            EC=4.1.2.4 {ECO:0000256|ARBA:ARBA00012515};
DE   AltName: Full=2-deoxy-D-ribose 5-phosphate aldolase {ECO:0000256|ARBA:ARBA00032755};
DE   AltName: Full=Phosphodeoxyriboaldolase {ECO:0000256|ARBA:ARBA00031814};
GN   ORFNames=NECAME_06663 {ECO:0000313|EMBL:ETN84859.1};
OS   Necator americanus (Human hookworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Strongylida;
OC   Ancylostomatoidea; Ancylostomatidae; Bunostominae; Necator.
OX   NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN84859.1, ECO:0000313|Proteomes:UP000053676};
RN   [1] {ECO:0000313|Proteomes:UP000053676}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24441737; DOI=10.1038/ng.2875;
RA   Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA   Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA   Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA   Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA   Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT   "Genome of the human hookworm Necator americanus.";
RL   Nat. Genet. 46:261-269(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde
CC         3-phosphate; Xref=Rhea:RHEA:12821, ChEBI:CHEBI:15343,
CC         ChEBI:CHEBI:59776, ChEBI:CHEBI:62877; EC=4.1.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00000764};
CC   -!- PATHWAY: Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate
CC       degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-
CC       deoxy-alpha-D-ribose 1-phosphate: step 2/2.
CC       {ECO:0000256|ARBA:ARBA00004816}.
CC   -!- SIMILARITY: Belongs to the DeoC/FbaB aldolase family. DeoC type 2
CC       subfamily. {ECO:0000256|ARBA:ARBA00009473}.
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DR   EMBL; KI657850; ETN84859.1; -; Genomic_DNA.
DR   RefSeq; XP_013307086.1; XM_013451632.1.
DR   AlphaFoldDB; W2TT68; -.
DR   STRING; 51031.W2TT68; -.
DR   EnsemblMetazoa; NECAME_06663; NECAME_06663; NECAME_06663.
DR   GeneID; 25346695; -.
DR   KEGG; nai:NECAME_06663; -.
DR   CTD; 25346695; -.
DR   OMA; RYSGPDY; -.
DR   OrthoDB; 1330179at2759; -.
DR   UniPathway; UPA00002; UER00468.
DR   Proteomes; UP000053676; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004139; F:deoxyribose-phosphate aldolase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009264; P:deoxyribonucleotide catabolic process; IEA:InterPro.
DR   GO; GO:0046386; P:deoxyribose phosphate catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00959; DeoC; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR011343; DeoC.
DR   InterPro; IPR002915; DeoC/FbaB/LacD_aldolase.
DR   PANTHER; PTHR10889; DEOXYRIBOSE-PHOSPHATE ALDOLASE; 1.
DR   PANTHER; PTHR10889:SF3; DEOXYRIBOSE-PHOSPHATE ALDOLASE; 1.
DR   Pfam; PF01791; DeoC; 1.
DR   PIRSF; PIRSF001357; DeoC; 1.
DR   SMART; SM01133; DeoC; 1.
DR   SUPFAM; SSF51569; Aldolase; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW   Schiff base {ECO:0000256|PIRSR:PIRSR001357-50}.
FT   ACT_SITE        214
FT                   /note="Schiff-base intermediate with acetaldehyde"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001357-50"
FT   ACT_SITE        231
FT                   /note="Proton donor/acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001357-50"
SQ   SEQUENCE   278 AA;  29661 MW;  5066A58AFB28386A CRC64;
     MGAFSQAEFD KEVSRDFNTQ EISSAIARYE KEAAALLKDK AQVRKVISYI DLTTLSGDDT
     KGRVVALVDR ALNPIPDDSS VTCAAVCVYP QRVADVTKHL TAKQKTLNVA SVAAGFPSGQ
     YHLQSKLLEV QLTVADGATE IDIVISRAAA LEGDWKNGEV LKFGLAVHDE VAALKGVCGN
     AHMKTILATG ELKTLTNIYK GSWASILAGS DFIKTSTGKE CTNATLEVGF KPAGGIKTPE
     EALAYIVLVK DVLGESWLSP ELFRIGASSL LDNCLKAI
//
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