ID W2TUE7_NECAM Unreviewed; 484 AA.
AC W2TUE7;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=B-box zinc finger {ECO:0000313|EMBL:ETN85249.1};
GN ORFNames=NECAME_06475 {ECO:0000313|EMBL:ETN85249.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN85249.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
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DR EMBL; KI657772; ETN85249.1; -; Genomic_DNA.
DR RefSeq; XP_013307476.1; XM_013452022.1.
DR AlphaFoldDB; W2TUE7; -.
DR STRING; 51031.W2TUE7; -.
DR EnsemblMetazoa; NECAME_06475; NECAME_06475; NECAME_06475.
DR GeneID; 25346507; -.
DR KEGG; nai:NECAME_06475; -.
DR CTD; 25346507; -.
DR OMA; RSEEYAM; -.
DR OrthoDB; 167377at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd19799; Bbox2_MYCBP2; 1.
DR CDD; cd16463; RING-H2_PHR; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45943; E3 UBIQUITIN-PROTEIN LIGASE MYCBP2; 1.
DR PANTHER; PTHR45943:SF1; E3 UBIQUITIN-PROTEIN LIGASE MYCBP2; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}; Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 73..121
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 275..326
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 484 AA; 53405 MW; 4FE96EC0C6289706 CRC64;
MRRELATALL GVVQLTTSLS KSGSRESMSK EAIPSILNSK RFWLSVAALA LVRDRSWLAL
SEKWNDVRTP SQGPITLCEN HDDGVTPAQV FCSDCECALC RECFSVMHLH KRNRSHRVTS
LAPPPARLEE IDIHQGCARM RVANLLILFH GESLNGLVEL PADPFAVLTT AVNIPAGRST
PSVCRFCSNA LDPHNQTYLS FVRIGKIFEF KILLRVTFQL VGVCSHPDCV RYSATACCRT
LACGHRCGGI AGEKHCLPCL VCTSEGTAQD GDDVCVVCFT DRLCAAPCIQ LGCGHLLHYH
CVRAVLEKRW PGPRIQFRFM NCPLCNVPIS HPGLSDLLEP LLALKADVTA KANMRLEFDG
LLGCTALTDP QSEYFGRSEE YAMDRYMYVL CNVCKKAYFG GESRCQMNTI MKVLFFSFGT
THFCAACHDD FQRLVCLPRN QFPPCPAGPR ATPAEGPCPL RQPHPPPGEE FALGCGICRN
ISTF
//
