ID W2TWX1_NECAM Unreviewed; 283 AA.
AC W2TWX1;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Neurotransmitter-gated ion-channel transmembrane region {ECO:0000313|EMBL:ETN86580.1};
GN ORFNames=NECAME_05884 {ECO:0000313|EMBL:ETN86580.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN86580.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
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DR EMBL; KI657524; ETN86580.1; -; Genomic_DNA.
DR RefSeq; XP_013308807.1; XM_013453353.1.
DR AlphaFoldDB; W2TWX1; -.
DR STRING; 51031.W2TWX1; -.
DR EnsemblMetazoa; NECAME_05884; NECAME_05884; NECAME_05884.
DR GeneID; 25345916; -.
DR KEGG; nai:NECAME_05884; -.
DR CTD; 25345916; -.
DR OMA; YMREPED; -.
DR OrthoDB; 2874625at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:UniProt.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd19049; LGIC_TM_anion; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 1.
DR InterPro; IPR006028; GABAA/Glycine_rcpt.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR PANTHER; PTHR18945:SF877; LIGAND-GATED ION CHANNEL; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR PRINTS; PR00253; GABAARECEPTR.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|EMBL:ETN86580.1};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 101..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 166..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 109..204
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
SQ SEQUENCE 283 AA; 32623 MW; B2F2127217B50C4B CRC64;
MCLLLSYRLT HDNLATIKFS SSATETALGE LDAHVKQEMN ATWFNDGPIR FNPEIALPEY
HIMSFDNDYC NGVFHYTITP NSSRLGDFSC LLAMVNLKRA IGFHLVQSYI PTGLIVAISW
VSFWIDRRAV PARVSLSFTT LLTLSTQGNG IRYALPPVSY AKAIDYFYGV CMLFIFGVLL
EFAMVNSYMR RANKYNHMAE KIQSNYGQKH IIVPSDYDSE YEEGPAKYYP HINKNSAHLM
YKALRYSRRA LAIDKAARFA FPSVFMLFNV IYWMYYMREP EDQ
//
