ID W2TWZ2_NECAM Unreviewed; 464 AA.
AC W2TWZ2;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Nuclear envelope integral membrane protein 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=NECAME_05904 {ECO:0000313|EMBL:ETN86600.1};
OS Necator americanus (Human hookworm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Ancylostomatidae; Bunostominae;
OC Necator.
OX NCBI_TaxID=51031 {ECO:0000313|EMBL:ETN86600.1, ECO:0000313|Proteomes:UP000053676};
RN [1] {ECO:0000313|Proteomes:UP000053676}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24441737; DOI=10.1038/ng.2875;
RA Tang Y.T., Gao X., Rosa B.A., Abubucker S., Hallsworth-Pepin K., Martin J.,
RA Tyagi R., Heizer E., Zhang X., Bhonagiri-Palsikar V., Minx P., Warren W.C.,
RA Wang Q., Zhan B., Hotez P.J., Sternberg P.W., Dougall A., Gaze S.T.,
RA Mulvenna J., Sotillo J., Ranganathan S., Rabelo E.M., Wilson R.K.,
RA Felgner P.L., Bethony J., Hawdon J.M., Gasser R.B., Loukas A., Mitreva M.;
RT "Genome of the human hookworm Necator americanus.";
RL Nat. Genet. 46:261-269(2014).
CC -!- SUBCELLULAR LOCATION: Nucleus inner membrane
CC {ECO:0000256|ARBA:ARBA00004575}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004575}; Nucleoplasmic side
CC {ECO:0000256|ARBA:ARBA00004575}.
CC -!- SIMILARITY: Belongs to the NEMP family.
CC {ECO:0000256|ARBA:ARBA00005748}.
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DR EMBL; KI657524; ETN86600.1; -; Genomic_DNA.
DR RefSeq; XP_013308827.1; XM_013453373.1.
DR AlphaFoldDB; W2TWZ2; -.
DR STRING; 51031.W2TWZ2; -.
DR EnsemblMetazoa; NECAME_05904; NECAME_05904; NECAME_05904.
DR GeneID; 25345936; -.
DR KEGG; nai:NECAME_05904; -.
DR CTD; 25345936; -.
DR OMA; YVIGYFA; -.
DR OrthoDB; 3091795at2759; -.
DR Proteomes; UP000053676; Unassembled WGS sequence.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR019358; NEMP_fam.
DR PANTHER; PTHR13598:SF1; AT07567P-RELATED; 1.
DR PANTHER; PTHR13598; UNCHARACTERIZED; 1.
DR Pfam; PF10225; NEMP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053676};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..464
FT /note="Nuclear envelope integral membrane protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004826829"
FT TRANSMEM 144..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..218
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 230..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 299..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 464 AA; 53907 MW; 2184B07E1B13CD75 CRC64;
MVYWLRTPCL VVCLLLIALF QRCSFTEICQ AKELKKSRWI VPAKLTNGLD LYIHRGLEYS
ATRAFTDIFL QLNLTDGDTY DLYKGDNCSI VEEEYRADNR MFGLLKSVDL WESHQLNVFN
DTVVGVVTRL PYTISAKVLK VNYVRFGVFA AGILLFLFAR RLVRNAVFFY GSGCSFGLLA
SLLILVFIVY RFAPKKLIGI PILIGGWSLA MYMLHFAWRN FATVVVQYQK YLAAYVVTVM
SISLAICYKK GPPKDSRSLD IAQWTMQAVA LLLIYASAQV QEVSVGVMTI LVLHQLSKSW
LWSLICSLAA AFRYIWRKVF PPKRRLLTME EYEKEGLETT KRELERLREY CRSPDADVWK
ITSKVHDPKR FARFVDGKER HVLEEEEDLY ESDAEFLDRE GDEDDVEDDD DRNFGVRRFY
DGDDDEWEER IIVRRTPKVR AENYPSPRKD EDLVFLDLCK MALI
//
