ID W2UMX7_9FLAO Unreviewed; 1046 AA.
AC W2UMX7;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=Hydrophobe/amphiphile efflux-1 (HAE1) family transporter {ECO:0000313|EMBL:ETN94697.1};
GN ORFNames=P278_26400 {ECO:0000313|EMBL:ETN94697.1};
OS Zhouia amylolytica AD3.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Zhouia.
OX NCBI_TaxID=1286632 {ECO:0000313|EMBL:ETN94697.1, ECO:0000313|Proteomes:UP000018850};
RN [1] {ECO:0000313|Proteomes:UP000018850}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AD3 {ECO:0000313|Proteomes:UP000018850};
RA Jin H., Jeon C.O.;
RT "Draft genome sequence from a member of Zhouia, isolated tidal flat.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETN94697.1, ECO:0000313|Proteomes:UP000018850}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AD3 {ECO:0000313|EMBL:ETN94697.1,
RC ECO:0000313|Proteomes:UP000018850};
RX PubMed=27151796;
RA Jia B., Jin H.M., Lee H.J., Jeon C.O.;
RT "Draft Genome Sequence of Zhouia amylolytica AD3, Isolated from Tidal Flat
RT Sediment.";
RL Genome Announc. 4:0-0(2016).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. {ECO:0000256|ARBA:ARBA00010942}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETN94697.1}.
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DR EMBL; AYXY01000023; ETN94697.1; -; Genomic_DNA.
DR RefSeq; WP_038267509.1; NZ_AYXY01000023.1.
DR AlphaFoldDB; W2UMX7; -.
DR STRING; 376730.SAMN04487906_1563; -.
DR PATRIC; fig|1286632.3.peg.2632; -.
DR eggNOG; COG0841; Bacteria.
DR Proteomes; UP000018850; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042908; P:xenobiotic transport; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004764; MdtF-like.
DR NCBIfam; TIGR00915; 2A0602; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF9; SIMILAR TO MULTIDRUG RESISTANCE PROTEIN MEXB; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018850};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 9..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..495
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 538..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 865..886
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 893..911
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 923..947
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 972..992
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1004..1026
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1046 AA; 113554 MW; EC41FD3F63C8BDB7 CRC64;
MLKKFIERPV LSTVISIIIV MLGVLGFYTL PVTQYPDIAP PTVQVNASYP GANAETIIES
VIIPIEEQIN GVEGMTYMVS SASNNGSANI TVYFEQGVDP DIAAVNVQNR VARANALLPA
EVIRAGVITQ KQQTSALMYV AMYSENPDYN DTYVQNYLNI NVRPEIQRID GVGDVTVFGG
KDYSMRIWID PAKLSSYGVT TTEVVQAIGE ESLEAAAGSL GQNSKQSFEY VIKYKGRYKT
AEEYNNIIIK SLGNGQFLRL KDVAKVELDA FSYNSISRSK GYPGVNFGIF QTAGSNAQEI
IKEVYDKLDQ LEKDFPEGVK YLVNYDTNKF LTASMNKVKH TLIEAFILVF FVVFIFLQDF
KSTLIPAIAV PVAIIGTFFF LGVFGYSINL LTLFALILAI GIVVDDAIVV VEAVHAKLEE
GYDSARKASI SAMSEISGAI ISITLVMAAV FVPITFIQGP SGVFYEQFGV TLIVAILISA
VNALTLSPAL CAIFLKPHTD KHNKKGLLQR FYAAFNVAFN ATTAKYVKSL GFLVKHKWIT
GGILAVAVAA IIWANNTTPT GFVPTEDRGV IFVNVELPQG SSLDRTYSVT EDLYKTMSSI
EGIKTASLIN GQNFFSGAGS SYAMGFIILD DWDNRETEAT SVNGILGQLY ARTATMAEAN
IIFFTPPSIP GFGSSDGFEM RLLDRSSGEL KDLDNVANEF VGALNQRPEI AFASNSFSTN
FPQLELDVNI AKAKEAGVSV SNILATLQGY IGGYYAADFS RFGKQFRVYV QADPEDRKDV
NSLNSMFVKN NQGEMAPVSE FVTLERVYGP QTVSRFNLFN AVTVNGSATP GFSSGDAIKA
VNEVAKEHLP NNYEVAYSGI TREEIASAGS SGIVFILSIV FVYFLLAAQY ESYILPFSVL
FSLPVGVAGA YLSTKFTGLE NNIYFQIALI MLIGLLAKNA ILIVEFAKQR REQGMSITDA
AIAGAKSRLR PILMTSFAFI LGLMPLVLAK GVGAEGNNSI GTGAAGGMLV GTILGVFIIP
VLYIVFQWLQ EKITGAPEVK SETEEA
//
