ID W2YHI5_PHYPR Unreviewed; 1400 AA.
AC W2YHI5;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 13-SEP-2023, entry version 33.
DE RecName: Full=[Histone H3]-lysine(27) N-trimethyltransferase {ECO:0008006|Google:ProtNLM};
GN ORFNames=F442_17367 {ECO:0000313|EMBL:ETP34262.1};
OS Phytophthora parasitica P10297.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=1317064 {ECO:0000313|EMBL:ETP34262.1, ECO:0000313|Proteomes:UP000018948};
RN [1] {ECO:0000313|EMBL:ETP34262.1, ECO:0000313|Proteomes:UP000018948}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P10297 {ECO:0000313|EMBL:ETP34262.1,
RC ECO:0000313|Proteomes:UP000018948};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Phytophthora parasitica P10297.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+)
CC + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:60292, Rhea:RHEA-COMP:15535, Rhea:RHEA-
CC COMP:15548, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.356;
CC Evidence={ECO:0000256|ARBA:ARBA00000090};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETP34262.1}.
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DR EMBL; ANIY01003648; ETP34261.1; -; Genomic_DNA.
DR EMBL; ANIY01003648; ETP34262.1; -; Genomic_DNA.
DR EnsemblProtists; ETP34261; ETP34261; F442_17367.
DR EnsemblProtists; ETP34262; ETP34262; F442_17367.
DR Proteomes; UP000018948; Unassembled WGS sequence.
DR GO; GO:0140951; F:histone H3K27 trimethyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd10519; SET_EZH; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR026489; CXC_dom.
DR InterPro; IPR045318; EZH1/2-like.
DR InterPro; IPR041355; Pre-SET_CXC.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR033467; Tesmin/TSO1-like_CXC.
DR PANTHER; PTHR45747; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR PANTHER; PTHR45747:SF4; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR Pfam; PF18264; preSET_CXC; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM01114; CXC; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51633; CXC; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000018948};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1130..1230
FT /note="CXC"
FT /evidence="ECO:0000259|PROSITE:PS51633"
FT DOMAIN 1249..1365
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 1..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 141..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 872..979
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1079..1132
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..52
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 239..261
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..330
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..397
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..418
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 872..895
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 941..979
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1084..1098
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1400 AA; 154406 MW; C42617BB71FDDF7E CRC64;
MPSPPSSVIV VDDSSDEEPA PASGRQSTPL LVSSSDESEA PRPKKLRVES PKVSVSDSKV
LNSAHNSESD EEVPSESKED EGATSEQSTS QNEKKKTSSA LLSSATADSD DDTAGETTQL
RFADSDGRMY ADAMSFSELQ AQQREFERLQ AMAHRKSAPR NTARRPTTGT KRKASEAAST
RNSSPISRTK SSVLKKTASP SPFDFDFPES SDESSESSSS TDDNRAALLS PRSKLMSLKD
VVAQERELAR LRDENAKMKD RAAPPKKKKK VASKSAPKQT TKSSSAQKIS FFFSAAQSNN
NVIDGTGWSE SEPSDDGKFE ENKSKGSYEP EPLLEESYSE SNKGVSDEEY VPSKPKTPSA
QPASARTNDQ KSKSGKTNKN RSSESKKSSK SKAKKGDNNS RSSSATSGVQ SSLPAQSGVV
SDKLARPRNA RDTVMHSTVW RNVCFDTAPS NLLPLPVDVA LPFFSEFDRP LLSYDVDGDL
RSKCKLLPQF GKSTHLISSA LVSDEPDQTI TQEDMDIRVT NIIQRELPRL RACHQRKTSA
VIAESRSKLR AYLAAHEAVQ NQRQDSQLEG KRLGDVDTLD KSLLNQMKQE KLTQALSLGY
TNIWGETIDV EEKLYPHDVN QLPNIRPLSK CTAYIGVKAN VRVEDDPILR YKPYFGEDDD
GADIDEAWYD AVAPKNSSLS SGLDGEVNEF MLRLVVRECG PTEKVFSALK KVPGFAQAYS
DYAEIKKLDD STRLAARRIK EAKDLISSKP PEFPLTKVAT LEPALGDADD SQKTLEERLA
PPATYFDSNL ARNHANRGYG LGLRSTDEYS ELLVTYRDMF CRMCYDYHCL EHGIEHPLPS
HRVDPANPPL HLSAVALAAT RKKEQEEIAE QLSCSPESCA STVSPPPSVD SGNCSAEDNF
KADDKNEEDV PTDEDVTMEN GSSEACYETA TDEEVVVAGE SNETRRSTRT ATRNNTLASR
SLTKQAAQPS KRKQSRPQRV QIYPQVADES EYLDDSHYAE VTAIVKKSLK DDENCSSECW
KAENSGETGL SSDEAKTTTK ALSETELVLL RKLHTIIGDN PCIISSMVKS TTCKEVGAFL
ESERQSKPTR TSSMDDMPLS PEGRSLHNGR KRGRARNSRS SNNRILLNRT RNNRLKDKGA
NHEYEPCNHE GACDSTDCSC MTRDHTCDKA CSCSRDCPNR FPGCRCSLGN CRTKACPCFV
AARECNPDLC ITCGASEVPA LIFDEERRNM SALDLGICCN VNILRGQHKK IGVAYSTTHG
WGAFALEPIK RGEFIYEYHG ALLSQDEAER RGSIYDKMTI SFLFDVDDDS VVDAIRKGNK
SKFANHSAVN KKCKGKVLTV GGEHRISIWA QQDISKGEEL FFDYGYHGET APDWSQLRIK
GSTLHGSKKK TEVKDKKKEN
//
