ID   W2Z5T1_PHYPR            Unreviewed;      1099 AA.
AC   W2Z5T1;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   RecName: Full=Tower domain-containing protein {ECO:0008006|Google:ProtNLM};
DE   Flags: Fragment;
GN   ORFNames=F442_10399 {ECO:0000313|EMBL:ETP42702.1};
OS   Phytophthora parasitica P10297.
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=1317064 {ECO:0000313|EMBL:ETP42702.1, ECO:0000313|Proteomes:UP000018948};
RN   [1] {ECO:0000313|EMBL:ETP42702.1, ECO:0000313|Proteomes:UP000018948}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=P10297 {ECO:0000313|EMBL:ETP42702.1,
RC   ECO:0000313|Proteomes:UP000018948};
RG   The Broad Institute Genomics Platform;
RA   Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA   Machado M., Johnson C.S., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA   Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA   Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Phytophthora parasitica P10297.";
RL   Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETP42702.1}.
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DR   EMBL; ANIY01002160; ETP42702.1; -; Genomic_DNA.
DR   AlphaFoldDB; W2Z5T1; -.
DR   EnsemblProtists; ETP42702; ETP42702; F442_10399.
DR   Proteomes; UP000018948; Unassembled WGS sequence.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 2.
DR   InterPro; IPR015525; BRCA2.
DR   InterPro; IPR015252; BRCA2_hlx.
DR   InterPro; IPR036315; BRCA2_hlx_sf.
DR   InterPro; IPR015187; BRCA2_OB_1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR   PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR   Pfam; PF09169; BRCA-2_helical; 1.
DR   Pfam; PF09103; BRCA-2_OB1; 1.
DR   SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 2.
PE   4: Predicted;
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018948}.
FT   DOMAIN          253..352
FT                   /note="Breast cancer type 2 susceptibility protein helical"
FT                   /evidence="ECO:0000259|Pfam:PF09169"
FT   DOMAIN          359..502
FT                   /note="BRCA2 OB1"
FT                   /evidence="ECO:0000259|Pfam:PF09103"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          58..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..89
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:ETP42702.1"
SQ   SEQUENCE   1099 AA;  124484 MW;  812ED34D3D9A68EE CRC64;
     ALRLRDDDEK LCSEEERDSN NAVQRFSNET VVERVNDNVS TLRGLGKSGL SERKIVERGD
     PCDSIAHQST TTSNDLAHSS RNRGSSLPPR RLSDSAYPLT DIHHQRLDCG DKENVHPENV
     LIRKTAALEA SKILRSSTSS MYLNSRLSLN HVALQQKKIN KALKPAIVRS KMTGKKRFHP
     PAASKRISFN DRKSLQHMDH FTAPRSKKQK VIDTEAQPFI YQESMKISLT TLISLDVNEG
     DNEVPRLQVL NSITAENALK VCFGQDGTLI LSSDESYDTA LFIGPRELYR QLKAGNHILK
     KTGATFVWFS NHYRWIVWKL AAMERSFPRL LLANYLTKDQ VLKQMTHRYQ RDLNDAQRSI
     VKKILQRDAS SLSCMVLCVA AVLPFSVDIN NAVDQQLPAC WNMALVLTDG WYSVYAVPDA
     PLASVLWKLH AKSSLVGSKL ATWNALLQNS TEGIDPLDCA IVCESKWRNP LLANEDLTQW
     PYLQLRYNST RRVRFDTRLG VEKLHYVTPV NSRHRKRQPQ LSFTLLKSVP LKSLEVGGGM
     VRSVRIRVTR ISPVLHLQAK EWTLGPRILC EEQLPLYFQL RSEYAQAVMR KKHQHEDRDE
     WSGDDQIDVP LPIPFIKVDV ECTHNPSKDQ GIGCGILTIW RPNEDLLSGG LREGVEYYAS
     SLTVNWKLDG GRGQDASLRL SSTKHSGFED IHEDSSANSQ IKQQRVCVDV QQATTNYRAN
     FEDGINGRRN ERRPTIDVCV CVVLVATREN QEVSSATKKQ ADVSLLDPEI KPQETRYVEH
     VFVTDQSCHL MSIRVSGMEV SMSKKKSNSP LKRSASSSFV FRRGSKNIWK VGAVLCLSGL
     EVSHYDEQLR VLDCVLVEST QIVSYPSKRS PFWDHFQLLQ REAGCTTRNS SQISSKCTGF
     AKYFTQLKKY VERDILRMDF VPSQECNEHV EVVEQERLTQ DLQAHEEGEH ATIDGDGKAS
     EIPNHLCWDA KVVKIMPLVG PNRFMFPGDV VAFACVNIGT DDTTFRTLYL TRELMLAMQT
     LLQEAEPSDH QVYGATAANN IAFVQSITEM LNKLKADFSV RFEVHQSTNE RLINSWKPWE
     RLNASYWMAV SVAAIPTVK
//