ID W2ZDS6_PHYPR Unreviewed; 685 AA.
AC W2ZDS6;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Polycystin cation channel PKD1/PKD2 domain-containing protein {ECO:0000259|Pfam:PF08016};
GN ORFNames=F442_08399 {ECO:0000313|EMBL:ETP45141.1};
OS Phytophthora parasitica P10297.
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=1317064 {ECO:0000313|EMBL:ETP45141.1, ECO:0000313|Proteomes:UP000018948};
RN [1] {ECO:0000313|EMBL:ETP45141.1, ECO:0000313|Proteomes:UP000018948}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=P10297 {ECO:0000313|EMBL:ETP45141.1,
RC ECO:0000313|Proteomes:UP000018948};
RG The Broad Institute Genomics Platform;
RA Russ C., Tyler B., Panabieres F., Shan W., Tripathy S., Grunwald N.,
RA Machado M., Johnson C.S., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Allen A.W., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J., Goldberg J.,
RA Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A., Ireland A.,
RA Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Phytophthora parasitica P10297.";
RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETP45141.1}.
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DR EMBL; ANIY01001753; ETP45141.1; -; Genomic_DNA.
DR AlphaFoldDB; W2ZDS6; -.
DR EnsemblProtists; ETP45141; ETP45141; F442_08399.
DR Proteomes; UP000018948; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR024862; TRPV.
DR PANTHER; PTHR10582:SF35; ION_TRANS DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR SMART; SM00248; ANK; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018948};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 225..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 295..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 362..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 389..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 66..98
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 307..454
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
FT REGION 500..521
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 644..671
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 543..561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 685 AA; 77340 MW; CBF31DB330378BA7 CRC64;
MEAEDSSAAA QTWYFLPDAA FDALVAQILV EPESARETPF VRRKDDGSTL LHVVAGWKHS
EQIDDSGWTP LLEAAQEGQF AVCQALLEAG ATPDLPCGEV TPLHAAVEVG NEEMVRWLLR
QPGTWPRRYN GEFFAFLLEK VPEAVTDYLD VFATVLNHSH KGYEAVKYTD LKVIYGEPIV
PVSDTALALV AESSAAHMIL SHRLMRLILH AKWHSFARTM FRQELTAYTL LVASYFIPTV
WGSPDWIHLK TKTHKMVAAL RFISWLLSIF LLLCVERSEC RGEGVRRYFS SFWNWIGVTT
YAAIICSIPL EFISFSELTQ QARNSVLALI IVCLWINLLQ FLQMSRNSGL IIAMMVHMVK
DIYRFFLLYS VFLLGFSGAF YLLLGGTSGY ETFTTSFITV YLMLYGQLTY DNFKDAKGYT
WYTSNFLLLV HLLSAVVVLL NILIAMMATT YAEVWDAAEA EALQSHAQAI VRLEKALTPK
VRREKFLELL AVSKPKAGTR STRERQYTVQ KEEEPEEDLS VSAREARRQN IILGVAKKMR
KISSVNKSSQ ARNSQPNHVV PVAESSDEVD QPGQDYPPKL KYIARQASRF AVHELAQDVV
ALNAAMKKPV YSVLEDGVRY ETPKKSTRGQ GKDEMQQQLT LSQQIRQQQQ LVDLQAQVEQ
LTTAMTNLQA SLLTKRIPGP PIPKY
//
