ID   W3AMG3_9FIRM            Unreviewed;       656 AA.
AC   W3AMG3;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   SubName: Full=Aconitate hydratase, putative, Aquifex type {ECO:0000313|EMBL:ETP71809.1};
GN   ORFNames=UYO_2198 {ECO:0000313|EMBL:ETP71809.1};
OS   Lachnospiraceae bacterium JC7.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae.
OX   NCBI_TaxID=1165092 {ECO:0000313|EMBL:ETP71809.1, ECO:0000313|Proteomes:UP000018967};
RN   [1] {ECO:0000313|EMBL:ETP71809.1, ECO:0000313|Proteomes:UP000018967}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JC7 {ECO:0000313|EMBL:ETP71809.1,
RC   ECO:0000313|Proteomes:UP000018967};
RA   Rosewarne C.P., Cheung J.L., Evans P.N., Tomkins N.W., Denman S.E.,
RA   O Cuiv P., Morrison M.;
RT   "Isolation and genomic characterisation of Lachnospiraceae sp. JC7, a newly
RT   identified member of the bovine rumen core microbiota.";
RL   Submitted (JUL-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETP71809.1}.
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DR   EMBL; ALYD01000028; ETP71809.1; -; Genomic_DNA.
DR   AlphaFoldDB; W3AMG3; -.
DR   PATRIC; fig|1165092.3.peg.2175; -.
DR   OrthoDB; 9764318at2; -.
DR   UniPathway; UPA00223; -.
DR   Proteomes; UP000018967; Unassembled WGS sequence.
DR   GO; GO:0003994; F:aconitate hydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.499.10; Aconitase, domain 3; 2.
DR   Gene3D; 3.20.19.10; Aconitase, domain 4; 1.
DR   InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR   InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR   InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR   InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR   InterPro; IPR006250; Aconitase_put.
DR   InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR   NCBIfam; TIGR01342; acon_putative; 1.
DR   PANTHER; PTHR43160; ACONITATE HYDRATASE B; 1.
DR   PANTHER; PTHR43160:SF3; ACONITATE HYDRATASE, MITOCHONDRIAL; 1.
DR   Pfam; PF00330; Aconitase; 2.
DR   Pfam; PF00694; Aconitase_C; 1.
DR   PRINTS; PR00415; ACONITASE.
DR   SUPFAM; SSF53732; Aconitase iron-sulfur domain; 1.
DR   SUPFAM; SSF52016; LeuD/IlvD-like; 1.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT   DOMAIN          8..286
FT                   /note="Aconitase/3-isopropylmalate dehydratase large
FT                   subunit alpha/beta/alpha"
FT                   /evidence="ECO:0000259|Pfam:PF00330"
FT   DOMAIN          289..408
FT                   /note="Aconitase/3-isopropylmalate dehydratase large
FT                   subunit alpha/beta/alpha"
FT                   /evidence="ECO:0000259|Pfam:PF00330"
FT   DOMAIN          528..583
FT                   /note="Aconitase A/isopropylmalate dehydratase small
FT                   subunit swivel"
FT                   /evidence="ECO:0000259|Pfam:PF00694"
SQ   SEQUENCE   656 AA;  71698 MW;  CF68832B7B5CC0F1 CRC64;
     MGDSLTKKII RTHFDSGSMT PGEDVFVTVD QTLTHDINAV MTYLAFEQIG LKRARTEVSV
     SNLDHNLLYI DFKTPDDHIY LRTAAEKYGV YVSRPGNGIC HMIHTCRFAA PGKLLMGGDS
     HTPSSGAVGA LAIGVGGMDV ATAMTGLPMR LTMPKVVKVN LTGHLKPGVN AKEVVLEMLR
     RVTIKGGLGK VYEYVGPGVL TLEVPERLTI ANMGAEMGAT TSIFPADEVV KKFMEAQDRG
     SEFIPMSADE DAEYDEEMEL DLSSLEPLIA LPHQPDNVVP VSSLREHPVV QQVFMGSCTN
     GSYSDFAKAA LVMQGHHVDE NVQCTAGIAS RQIYKQLMKD GYLDMLIDAG VRIMELSCGP
     CCAIGQVPPT NGIAVRTSNR NFRGRAGSPN ANVYLVSPET AAATAIKGTF ATAFDVMGED
     VGKLASVHEP EHYFVDDSML IKPLTEEEAE KVEVIKGPNI APLPVPEKPE KDLYCRISLK
     GRDNISTDDI TPAGAEFSSM RSNIPLMSKY CYNRYDPEFA ERARGLGKSI IIGGENYGQG
     SSREHAAINP MYLGVKCVIA KSIARIHKGN LINHGIVPML FENPEDYEKL ELLDELEIVD
     FPEQIKKHEV TVRDKTGDFS FKCKLDISDA EMATILDGGQ LMHLKKQLVD RGIIKE
//