ID W3WHX4_PESFW Unreviewed; 347 AA.
AC W3WHX4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
GN ORFNames=PFICI_14444 {ECO:0000313|EMBL:ETS73498.1};
OS Pestalotiopsis fici (strain W106-1 / CGMCC3.15140).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Sporocadaceae; Pestalotiopsis.
OX NCBI_TaxID=1229662 {ECO:0000313|EMBL:ETS73498.1, ECO:0000313|Proteomes:UP000030651};
RN [1] {ECO:0000313|Proteomes:UP000030651}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=W106-1 / CGMCC3.15140 {ECO:0000313|Proteomes:UP000030651};
RX PubMed=25623211; DOI=10.1186/s12864-014-1190-9;
RA Wang X., Zhang X., Liu L., Xiang M., Wang W., Sun X., Che Y., Guo L.,
RA Liu G., Guo L., Wang C., Yin W.B., Stadler M., Zhang X., Liu X.;
RT "Genomic and transcriptomic analysis of the endophytic fungus
RT Pestalotiopsis fici reveals its lifestyle and high potential for synthesis
RT of natural products.";
RL BMC Genomics 16:28-28(2015).
CC -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC family. Dihydroflavonol-4-reductase subfamily.
CC {ECO:0000256|ARBA:ARBA00023445}.
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DR EMBL; KI912121; ETS73498.1; -; Genomic_DNA.
DR RefSeq; XP_007841216.1; XM_007843025.1.
DR AlphaFoldDB; W3WHX4; -.
DR STRING; 1229662.W3WHX4; -.
DR GeneID; 19279457; -.
DR KEGG; pfy:PFICI_14444; -.
DR eggNOG; KOG1502; Eukaryota.
DR HOGENOM; CLU_007383_9_2_1; -.
DR InParanoid; W3WHX4; -.
DR OMA; HTNSFAC; -.
DR OrthoDB; 1200131at2759; -.
DR Proteomes; UP000030651; Unassembled WGS sequence.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10366:SF564; 3BETA_HSD DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000030651}.
FT DOMAIN 13..239
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
FT REGION 293..314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 347 AA; 37812 MW; C67FBEECA3B72D7D CRC64;
MAPVDPQRKG RVLVTGGNGF IGHHVVRELL EKTPHQVEAT VQSSQMSAHL QAVHRNHPRL
TMHVVPDITR ADAFVQAAQH CHAIIHLAAP PMTTGSDFEN DLVLPALQCV QVRIQAICHA
ADANESVTRL VYCSSFAAVF DPSPSGSLPS KVYTEDDWNP TTYEQASKAP ELMLSYQGSK
ALAEREVRKL CREQSKWDLV TICPGIVFGA PVDGSVGTVQ ELAQTNAALW DMFDKKDVPQ
TTVPIWTAVT SLAEAQISAL SSSKAGGERF LVVNGAYENQ ELCDYLISSD LDEDSKSRVP
TGNPGHRSNH WKADGSKAAE SLEFSKPTLK DTIVGVRNYL FRLAKSA
//
