ID W3XAL1_PESFW Unreviewed; 308 AA.
AC W3XAL1;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=6-phosphogluconate dehydrogenase NADP-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PFICI_04333 {ECO:0000313|EMBL:ETS82457.1};
OS Pestalotiopsis fici (strain W106-1 / CGMCC3.15140).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Sporocadaceae; Pestalotiopsis.
OX NCBI_TaxID=1229662 {ECO:0000313|EMBL:ETS82457.1, ECO:0000313|Proteomes:UP000030651};
RN [1] {ECO:0000313|Proteomes:UP000030651}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=W106-1 / CGMCC3.15140 {ECO:0000313|Proteomes:UP000030651};
RX PubMed=25623211; DOI=10.1186/s12864-014-1190-9;
RA Wang X., Zhang X., Liu L., Xiang M., Wang W., Sun X., Che Y., Guo L.,
RA Liu G., Guo L., Wang C., Yin W.B., Stadler M., Zhang X., Liu X.;
RT "Genomic and transcriptomic analysis of the endophytic fungus
RT Pestalotiopsis fici reveals its lifestyle and high potential for synthesis
RT of natural products.";
RL BMC Genomics 16:28-28(2015).
CC -!- SIMILARITY: Belongs to the HIBADH-related family. NP60 subfamily.
CC {ECO:0000256|ARBA:ARBA00007598}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KI912111; ETS82457.1; -; Genomic_DNA.
DR RefSeq; XP_007831105.1; XM_007832914.1.
DR AlphaFoldDB; W3XAL1; -.
DR STRING; 1229662.W3XAL1; -.
DR GeneID; 19269346; -.
DR KEGG; pfy:PFICI_04333; -.
DR eggNOG; KOG0409; Eukaryota.
DR HOGENOM; CLU_035117_5_1_1; -.
DR InParanoid; W3XAL1; -.
DR OrthoDB; 2715114at2759; -.
DR Proteomes; UP000030651; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43580:SF3; 6-PHOSPHOGLUCONATE DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G11600); 1.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000030651}.
FT DOMAIN 6..156
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 174..294
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 180
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 308 AA; 32441 MW; AC74B9A5015A1D28 CRC64;
MASQLFWIGL GNMGRGMCKN LVEKGPLGGS PLLVYNRSSK RSADLAVKLG SKVKAVSSIE
EGVKQADIIF TCLSNDQAVE DVYRTISALG NINGKLFADC STIHPDSTEK VAKIVTDAGA
DFVASPVFGA PPMADAGQLI FVPAGPKAAV ERLRPYTTGV MGKAELPMED EPYGTASTLK
IIGNTFVLNM VTQLGEGFTL AEKTGVGAAR VKKFVDGLFG GPYSAYGERM LSGAYHSMEE
PLFSADNAIK DASHAEDLAK TAGMEVKNAT TAKQYLEEVA EHAGGAKGDV AAIYGAARMR
AGLEYENN
//
