ID W3XEQ4_PESFW Unreviewed; 399 AA.
AC W3XEQ4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Tyrosinase copper-binding domain-containing protein {ECO:0000259|PROSITE:PS00498};
GN ORFNames=PFICI_02608 {ECO:0000313|EMBL:ETS84583.1};
OS Pestalotiopsis fici (strain W106-1 / CGMCC3.15140).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Sporocadaceae; Pestalotiopsis.
OX NCBI_TaxID=1229662 {ECO:0000313|EMBL:ETS84583.1, ECO:0000313|Proteomes:UP000030651};
RN [1] {ECO:0000313|Proteomes:UP000030651}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=W106-1 / CGMCC3.15140 {ECO:0000313|Proteomes:UP000030651};
RX PubMed=25623211; DOI=10.1186/s12864-014-1190-9;
RA Wang X., Zhang X., Liu L., Xiang M., Wang W., Sun X., Che Y., Guo L.,
RA Liu G., Guo L., Wang C., Yin W.B., Stadler M., Zhang X., Liu X.;
RT "Genomic and transcriptomic analysis of the endophytic fungus
RT Pestalotiopsis fici reveals its lifestyle and high potential for synthesis
RT of natural products.";
RL BMC Genomics 16:28-28(2015).
CC -!- COFACTOR:
CC Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC Evidence={ECO:0000256|ARBA:ARBA00001973};
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DR EMBL; KI912110; ETS84583.1; -; Genomic_DNA.
DR RefSeq; XP_007829380.1; XM_007831189.1.
DR AlphaFoldDB; W3XEQ4; -.
DR STRING; 1229662.W3XEQ4; -.
DR GeneID; 19267621; -.
DR KEGG; pfy:PFICI_02608; -.
DR eggNOG; ENOG502QV06; Eukaryota.
DR HOGENOM; CLU_035914_0_1_1; -.
DR InParanoid; W3XEQ4; -.
DR OMA; RTEWYIN; -.
DR OrthoDB; 4070889at2759; -.
DR Proteomes; UP000030651; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR InterPro; IPR008922; Di-copper_centre_dom_sf.
DR InterPro; IPR002227; Tyrosinase_Cu-bd.
DR PANTHER; PTHR11474:SF124; TYROSINASE; 1.
DR PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR Pfam; PF00264; Tyrosinase; 1.
DR PRINTS; PR00092; TYROSINASE.
DR SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR PROSITE; PS00498; TYROSINASE_2; 1.
PE 4: Predicted;
KW Copper {ECO:0000256|ARBA:ARBA00023008}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000030651};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 316..327
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00498"
SQ SEQUENCE 399 AA; 45203 MW; 5A24D240B141AF57 CRC64;
MLSLQSLAAL VCNVIVHLLF LNGVAPLLLR STVVAALSVS HTQSSRLLEA RANESCRDPL
VRTEWYINFS NQVMFLIFTK FIDRRRMSAN QQDSYIAALK CMLEKPAEEY PVVPAASNRY
EDFVAAHIFS VWNAHYVGAF YPWHRWFLFH FEKELQSCGF QGGLPYWDWT LDTTSEQKFL
GSPIFDTVRG FGGNGEYVPT NQLTPAPTML LASRPKLLAA NRTGGGCLVD GPFSGLSSEL
GPRDNLKKMG RHCVTRDLGY AYMWNTTDLN LVNTAMKFPN FGLYGNKTEF SYHAGGHWAI
GGEYATMSDM WASPLDPIFF LHHSNLDRAW WSWETRDLDV RVDDISGPLF TQDYHNKEGG
NYTIDSIIRL GVTSPVEVRI GDIMHIQQGP LCYTYDQLY
//
