ID   W4AS97_9BACL            Unreviewed;       687 AA.
AC   W4AS97;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Peptidoglycan glycosyltransferase {ECO:0000313|EMBL:ETT34370.1};
GN   ORFNames=C169_18469 {ECO:0000313|EMBL:ETT34370.1};
OS   Paenibacillus sp. FSL R5-808.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae; Paenibacillus.
OX   NCBI_TaxID=1227076 {ECO:0000313|EMBL:ETT34370.1, ECO:0000313|Proteomes:UP000019053};
RN   [1] {ECO:0000313|EMBL:ETT34370.1, ECO:0000313|Proteomes:UP000019053}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FSL R5-808 {ECO:0000313|EMBL:ETT34370.1,
RC   ECO:0000313|Proteomes:UP000019053};
RX   PubMed=24422886; DOI=10.1186/1471-2164-15-26;
RA   Moreno Switt A.I., Andrus A.D., Ranieri M.L., Orsi R.H., Ivy R.,
RA   den Bakker H.C., Martin N.H., Wiedmann M., Boor K.J.;
RT   "Genomic comparison of sporeforming bacilli isolated from milk.";
RL   BMC Genomics 15:26-26(2014).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ETT34370.1}.
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DR   EMBL; ASPT01000032; ETT34370.1; -; Genomic_DNA.
DR   AlphaFoldDB; W4AS97; -.
DR   PATRIC; fig|1227076.4.peg.3811; -.
DR   Proteomes; UP000019053; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR   Pfam; PF03717; PBP_dimer; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transferase {ECO:0000313|EMBL:ETT34370.1};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        25..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          66..266
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          322..654
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
FT   REGION          664..687
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        664..678
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   687 AA;  76190 MW;  4790AA7100C91590 CRC64;
     MGFRPYKNVP DEEETKSRFH GRINIFFFSA FLIFCIIIVR LAILQFVEGP ELASQESGGE
     QKHFPLQPIR GSIIDASGEK LAYSTASNSL YITLMKDYSE KTDKGKANQP EAEEMAKRIV
     QVFNKYGDPN IEQKTVKNVM DDLDLEYIKQ HGYEPRLIKS DLTKEEIAYF MENRAKFPGI
     QIVEENVRHY DPDTVAVQTI GYLKKFKGSK DLKDYQAIDQ SNKDQDNPGL IYTEEEWIGY
     DGLERMYQEE LRGKSGYLSI PINPQNMVDG VPTMVAPEKG LNIHTTIHKD IQVATEQAIM
     DRLQYLHTNP VSGKLHKDAV TGYAVAMEID TGHVVAMATM PDYDSNVWGS GGKITQDVVD
     SSGNGTITIY GSGRSGHGFE SMIFLGSVIK PLTVLIGLNE GLFGPNDTYP DQGYASIGRE
     GSETKIRNSS GHRIGPIKPQ QAIQQSSNAF MIDWVGKRLV NKYGGEKGVT VWDKYMEQFG
     LGVVTGSGLP KEHKGLKNYT DTKAAGSNLA ALAYASFGQQ GKYTPLQLAQ YTVMLANEGK
     RIKPQLVSKI TDQNGKVVKE FGREILNEVH FPKQYWQIIK QGMNTQGIAG FEDFKYDFAR
     KTGTSEQSYK GVNLDNGVFI AFAPRDNPKL AVAVVVPEGG FGSQSAAPIA RKIFDAYDEV
     YGLDGTPHPK KADEQAEDGS PDESGDN
//