ID W4EPV7_9BACL Unreviewed; 563 AA.
AC W4EPV7;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=Septation ring formation regulator EzrA {ECO:0000256|HAMAP-Rule:MF_00728};
GN Name=ezrA {ECO:0000256|HAMAP-Rule:MF_00728};
GN ORFNames=C176_16567 {ECO:0000313|EMBL:ETT82620.1};
OS Viridibacillus arenosi FSL R5-213.
OC Bacteria; Bacillota; Bacilli; Bacillales; Planococcaceae; Viridibacillus.
OX NCBI_TaxID=1227360 {ECO:0000313|EMBL:ETT82620.1, ECO:0000313|Proteomes:UP000019062};
RN [1] {ECO:0000313|EMBL:ETT82620.1, ECO:0000313|Proteomes:UP000019062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FSL R5-213 {ECO:0000313|EMBL:ETT82620.1,
RC ECO:0000313|Proteomes:UP000019062};
RX PubMed=24422886; DOI=10.1186/1471-2164-15-26;
RA Moreno Switt A.I., Andrus A.D., Ranieri M.L., Orsi R.H., Ivy R.,
RA den Bakker H.C., Martin N.H., Wiedmann M., Boor K.J.;
RT "Genomic comparison of sporeforming bacilli isolated from milk.";
RL BMC Genomics 15:26-26(2014).
CC -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC formation at polar sites. Interacts either with FtsZ or with one of its
CC binding partners to promote depolymerization. {ECO:0000256|HAMAP-
CC Rule:MF_00728}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_00728};
CC Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_00728}.
CC Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Note=Colocalized with FtsZ to the
CC nascent septal site. {ECO:0000256|HAMAP-Rule:MF_00728}.
CC -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000256|HAMAP-
CC Rule:MF_00728}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETT82620.1}.
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DR EMBL; ASQA01000034; ETT82620.1; -; Genomic_DNA.
DR RefSeq; WP_038187849.1; NZ_ASQA01000034.1.
DR AlphaFoldDB; W4EPV7; -.
DR PATRIC; fig|1227360.4.peg.3374; -.
DR eggNOG; COG4477; Bacteria.
DR Proteomes; UP000019062; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005940; C:septin ring; IEA:InterPro.
DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR HAMAP; MF_00728; EzrA; 1.
DR InterPro; IPR010379; EzrA.
DR Pfam; PF06160; EzrA; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_00728};
KW Cell division {ECO:0000256|HAMAP-Rule:MF_00728};
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_00728};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|HAMAP-
KW Rule:MF_00728};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_00728};
KW Reference proteome {ECO:0000313|Proteomes:UP000019062};
KW Septation {ECO:0000256|ARBA:ARBA00023210, ECO:0000256|HAMAP-Rule:MF_00728};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_00728};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_00728}.
FT TOPO_DOM 1..2
FT /note="Extracellular"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT TRANSMEM 6..22
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TOPO_DOM 22..563
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT COILED 105..153
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT COILED 249..276
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT COILED 362..396
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
SQ SEQUENCE 563 AA; 65761 MW; 694FD5BB8CD3415E CRC64;
MQYIIPVIIV LCIIVAFIFI LRRKHNKEIQ RLDQKKLQIQ NKPVLEELTK VKALNMNGQT
EEMFERWRNK WTELMDVEMP KIDVLLFDAE ELVDKFQFGK ATDIEKEIES RINEYDQEMI
QILKELGELI GSEEKNRIEI EQLKDQYRSA RKTLLAHQYS YGPAAGPLEK RLETFNPKFE
EYEVLTESGN YLQAREIVIM LDEEGQHIFK LINEIPALLT DIQHKIPSHI HELRNGQREM
EEQSFFLKHL ELNGKLDVME ESIDEFKQQI ADLNITSVQH RVNEIKDEID SFYDALEKEV
MAKRFVDENF EQIGTRLENV IVSTDETAKE AEEVQKGYHL SEKDAALPSN CKQQLMSVRQ
RYELLSIQVK EEQSAYSSLQ EELKGVKEET ERLFEEQDRF ADRLKSLRID ENKARATLGN
LKQLLHETDR MLNKANIPGI PEEMDIRLEE AEEQLFIVVQ SLKEVPLNMV AVHKNLDTAE
KCIQDVHNTA TEMLENVLLI ERIIQYGNRY RASNPTMHQR LLEAEQAFRE FRYAKALENA
ATAVEAAEPG AMKKIQVLAK DDN
//
