ID W4F6Y9_9BACL Unreviewed; 302 AA.
AC W4F6Y9;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=DNA-3-methyladenine glycosylase II {ECO:0000256|ARBA:ARBA00012000};
DE EC=3.2.2.21 {ECO:0000256|ARBA:ARBA00012000};
GN ORFNames=C176_00940 {ECO:0000313|EMBL:ETT88580.1};
OS Viridibacillus arenosi FSL R5-213.
OC Bacteria; Bacillota; Bacilli; Bacillales; Planococcaceae; Viridibacillus.
OX NCBI_TaxID=1227360 {ECO:0000313|EMBL:ETT88580.1, ECO:0000313|Proteomes:UP000019062};
RN [1] {ECO:0000313|EMBL:ETT88580.1, ECO:0000313|Proteomes:UP000019062}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FSL R5-213 {ECO:0000313|EMBL:ETT88580.1,
RC ECO:0000313|Proteomes:UP000019062};
RX PubMed=24422886; DOI=10.1186/1471-2164-15-26;
RA Moreno Switt A.I., Andrus A.D., Ranieri M.L., Orsi R.H., Ivy R.,
RA den Bakker H.C., Martin N.H., Wiedmann M., Boor K.J.;
RT "Genomic comparison of sporeforming bacilli isolated from milk.";
RL BMC Genomics 15:26-26(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-
CC methylguanine, 7-methylguanine and 7-methyladenine.; EC=3.2.2.21;
CC Evidence={ECO:0000256|ARBA:ARBA00000086};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETT88580.1}.
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DR EMBL; ASQA01000002; ETT88580.1; -; Genomic_DNA.
DR RefSeq; WP_038178886.1; NZ_ASQA01000002.1.
DR AlphaFoldDB; W4F6Y9; -.
DR PATRIC; fig|1227360.4.peg.190; -.
DR eggNOG; COG0122; Bacteria.
DR Proteomes; UP000019062; Unassembled WGS sequence.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0008534; F:oxidized purine nucleobase lesion DNA N-glycosylase activity; IEA:InterPro.
DR GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd00056; ENDO3c; 1.
DR Gene3D; 3.30.310.20; DNA-3-methyladenine glycosylase AlkA, N-terminal domain; 1.
DR Gene3D; 1.10.1670.10; Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal); 1.
DR InterPro; IPR037046; AlkA_N_sf.
DR InterPro; IPR011257; DNA_glycosylase.
DR InterPro; IPR003265; HhH-GPD_domain.
DR InterPro; IPR023170; HhH_base_excis_C.
DR InterPro; IPR012904; OGG_N.
DR PANTHER; PTHR43003; DNA-3-METHYLADENINE GLYCOSYLASE; 1.
DR PANTHER; PTHR43003:SF12; DNA-3-METHYLADENINE GLYCOSYLASE; 1.
DR Pfam; PF00730; HhH-GPD; 1.
DR Pfam; PF07934; OGG_N; 1.
DR SMART; SM00478; ENDO3c; 1.
DR SUPFAM; SSF48150; DNA-glycosylase; 1.
PE 4: Predicted;
KW Glycosidase {ECO:0000313|EMBL:ETT88580.1};
KW Hydrolase {ECO:0000313|EMBL:ETT88580.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000019062}.
FT DOMAIN 136..301
FT /note="HhH-GPD"
FT /evidence="ECO:0000259|SMART:SM00478"
SQ SEQUENCE 302 AA; 35444 MW; 5FDB6C90ED4E6BA4 CRC64;
MNWINHQSYI EIYPPEEFNF EECLLFLNRS KQEVLHQIRD GYLYKLIKIN QELVLCKIGC
IQNIILVEFP ITPPSKGIRE EVASYIWEWF DLETDLRVFY DAAKQDKVLQ IFVQKYYGLR
IMCIPDLFEA LSWAIIGQQI NLTFAYIIKK RFVETFGESL TFMGDTFWLF PTYEKIATIT
VDDLRELQFS VRKAEYVIDV AKIMTKGILT KELILGYQDY QQIQKSLMKI RGIGAWSADY
VMMKCLHHPS AFPITDVGLH NALKIHLGLG RKPTIDEIKE LSANWAGLQA YATFYLWRSL
YE
//
