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Database: UniProt
Entry: W4GRX8_9STRA
LinkDB: W4GRX8_9STRA
Original site: W4GRX8_9STRA 
ID   W4GRX8_9STRA            Unreviewed;       919 AA.
AC   W4GRX8;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   23-MAY-2018, entry version 25.
DE   RecName: Full=Phosphodiesterase {ECO:0000256|RuleBase:RU363067};
DE            EC=3.1.4.- {ECO:0000256|RuleBase:RU363067};
GN   ORFNames=H257_05110 {ECO:0000313|EMBL:ETV82490.1};
OS   Aphanomyces astaci.
OC   Eukaryota; Stramenopiles; Oomycetes; Saprolegniales; Saprolegniaceae;
OC   Aphanomyces.
OX   NCBI_TaxID=112090 {ECO:0000313|EMBL:ETV82490.1, ECO:0000313|Proteomes:UP000019040};
RN   [1] {ECO:0000313|EMBL:ETV82490.1, ECO:0000313|Proteomes:UP000019040}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=APO3 {ECO:0000313|EMBL:ETV82490.1,
RC   ECO:0000313|Proteomes:UP000019040};
RG   The Broad Institute Genomics Platform;
RA   Russ C., Tyler B., van West P., Dieguez-Uribeondo J., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Abouelleil A., Alvarado L.,
RA   Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S.,
RA   Hansen M., Howarth C., Imamovic A., Ireland A., Larimer J.,
RA   McCowan C., Murphy C., Pearson M., Poon T.W., Priest M., Roberts A.,
RA   Saif S., Shea T., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Aphanomyces astaci APO3.";
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000256|RuleBase:RU363067};
CC       Note=Binds 2 divalent metal cations per subunit. Site 1 may
CC       preferentially bind zinc ions, while site 2 has a preference for
CC       magnesium and/or manganese ions. {ECO:0000256|RuleBase:RU363067};
CC   -!- SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase
CC       family. {ECO:0000256|RuleBase:RU363067,
CC       ECO:0000256|SAAS:SAAS01040771}.
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DR   EMBL; KI913122; ETV82490.1; -; Genomic_DNA.
DR   EMBL; KI913122; ETV82491.1; -; Genomic_DNA.
DR   RefSeq; XP_009828159.1; XM_009829857.1.
DR   RefSeq; XP_009828160.1; XM_009829858.1.
DR   EnsemblProtists; ETV82490; ETV82490; H257_05110.
DR   EnsemblProtists; ETV82491; ETV82491; H257_05110.
DR   GeneID; 20807106; -.
DR   Proteomes; UP000019040; Unassembled WGS sequence.
DR   GO; GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 1.10.1300.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 3.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR023088; PDEase.
DR   InterPro; IPR002073; PDEase_catalytic_dom.
DR   InterPro; IPR036971; PDEase_catalytic_dom_sf.
DR   InterPro; IPR023174; PDEase_CS.
DR   Pfam; PF01590; GAF; 2.
DR   Pfam; PF00233; PDEase_I; 1.
DR   PRINTS; PR00387; PDIESTERASE1.
DR   SMART; SM00065; GAF; 3.
DR   SMART; SM00471; HDc; 1.
DR   PROSITE; PS00126; PDEASE_I_1; 1.
DR   PROSITE; PS51845; PDEASE_I_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000019040};
KW   Hydrolase {ECO:0000256|RuleBase:RU363067,
KW   ECO:0000256|SAAS:SAAS01040760};
KW   Metal-binding {ECO:0000256|RuleBase:RU363067,
KW   ECO:0000256|SAAS:SAAS01040765};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019040}.
FT   DOMAIN      703    919       PDEase. {ECO:0000259|PROSITE:PS51845}.
SQ   SEQUENCE   919 AA;  102344 MW;  85CA19E4E59E6B1A CRC64;
     MASPAEGLHL MVPKHILQNV VEGTKSLLSE KRLLQQRLDE AGGRIFALER QLADQQMRTE
     VAMQSAAKTP ASNASHKFKN LTLQVMKTKR SVGDGRDGAL SPTSDHMRKD EEIYKLRGKT
     NELETLIAAT RAITHQTAHR EVVSSTLNAA RNLVSARMYS LALTNEGNSS MLLYSMGVLS
     LAAAGEDRHV NKYGGFQDEG SMGVDNTTTF GHVIMTGTVF DALQATATGM FESQMDDFDF
     VPHSVLCMPI RNAHGTILGA LQVVTQRQHS DEYMQNQVFT SLDKDRLEHL CVVSGSAIWN
     LRLSKERQTA QTRIEILLRL NRSIAVESNS AAVLEKIMDV SYELLRCERV SLFVKIQGES
     DLFVAHANDA TRGQYISIDK GIAGLVARTG QVVTTNNVDE HPCFDRELDE RTGNSTKKLL
     CVPVKDPDGT ILAVVQAVNK VDKSDFSIED TLFLNYIAEA AGISLHKSYL HNEVIIAKRL
     TDVRLKLSDY VLNHNDIHSL TDLIMVHGKA IMDCDRFGFL LVDHLKNELW ITSNNGNLGE
     QVTLRQPIYK GISGLVATTG ETVCTRDAYT HSLFDPTHDN ITGYRTTSVL CMPVFEEHVP
     TKPKVVAVAM CINKLQGSQV IAFNSQDKLT MARFCKEMQH ALGQMSLEVC YFKVVSDRNL
     SGSSEVTEAG VISSLLQKHS RNTSGIMTAN LTQLDGGGDH RVADDVFAHD VKLTQRPELD
     SWDLDILSFS FTEVIQSVQT LFRAYGFIDT YEISPDKMQS FVASVAQHYR ANSYHNFYHA
     FQVLHSAHIQ LKVHMRKLLT GLDIFALMIA ALCHDVDHPG NNNDFEVKCV SSIALTHNDD
     AVLERHHCRV TFLILNTPST NILEKVAPDA FRSIRRTIIR CIMATDMANH FTQCKALENM
     SRHQLQDAVN RWGVVVRIG
//
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