ID W4ID03_PLAFA Unreviewed; 541 AA.
AC W4ID03;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=PFNF135_04225 {ECO:0000313|EMBL:ETW41578.1};
OS Plasmodium falciparum NF135/5.C10.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036726 {ECO:0000313|EMBL:ETW41578.1, ECO:0000313|Proteomes:UP000019114};
RN [1] {ECO:0000313|EMBL:ETW41578.1, ECO:0000313|Proteomes:UP000019114}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF135/5.C10 {ECO:0000313|EMBL:ETW41578.1,
RC ECO:0000313|Proteomes:UP000019114};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum NF135/5.C10.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW41578.1, ECO:0000313|Proteomes:UP000019114}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF135/5.C10 {ECO:0000313|EMBL:ETW41578.1,
RC ECO:0000313|Proteomes:UP000019114};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum NF135/5.C10.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
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DR EMBL; KI926058; ETW41578.1; -; Genomic_DNA.
DR AlphaFoldDB; W4ID03; -.
DR EnsemblProtists; ETW41578; ETW41578; PFNF135_04225.
DR Proteomes; UP000019114; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT DOMAIN 192..512
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
FT REGION 122..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 541 AA; 63847 MW; 97C62EA31BAEBFB6 CRC64;
MLKFNCIPYK NIGTFHDALK QHNIKFEKRN NFIFFHAFSS LRKYKSQHSE KNNILNKLFF
FKKEYKSYFH KLSNNLFLSS KRKNEVIFHK MDKTNKNVQM IKHNIITSQR RENGMEQYTA
IDGKTKVNNN NNNDNSNNNN DNSNNNKNNN NDMKANIHQD MDKVKNNMID LELSELWTKK
SLIVNFQNNI CEIILNRPEK LNAINKDMIN ALLNIIKSLD NDERCFMVII RSTNSNCFSS
GSDVKYVVEN KEQGIQHLKQ LYLYINYISQ MKKNLLCIWN GYVMGGGLGI SIYSKYKVIN
KNAIFAMPEN KIGFFPDIGC CYFFRKYFGR NIGLHLGLTS LRLNEVDLIN FNVCNNYIEN
VDTFMDNLNN IKATNQEDFN KKLNNLLTNK YVSKMSYNKS NNPVLTDELI NNINTYYSSA
NTLEDLITKL KKDNNDFCKK LLSDIYSNCY FSCMFWFSYY LYNYEKSLEE VLNNDFKITQ
YFLFHKNSFE RGVTEVLVKK NKNFQWSKDE ETNNADFEDI DDILMNKNLL SIKEEFTNMS
E
//
