ID   W4IG08_PLAFA            Unreviewed;      1056 AA.
AC   W4IG08;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Diphosphate-fructose-6-phosphate 1-phosphotransferase {ECO:0000313|EMBL:ETW42055.1};
GN   ORFNames=PFNF135_03553 {ECO:0000313|EMBL:ETW42055.1};
OS   Plasmodium falciparum NF135/5.C10.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=1036726 {ECO:0000313|EMBL:ETW42055.1, ECO:0000313|Proteomes:UP000019114};
RN   [1] {ECO:0000313|EMBL:ETW42055.1, ECO:0000313|Proteomes:UP000019114}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NF135/5.C10 {ECO:0000313|EMBL:ETW42055.1,
RC   ECO:0000313|Proteomes:UP000019114};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA   Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA   Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA   Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA   Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Annotation of Plasmodium falciparum NF135/5.C10.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ETW42055.1, ECO:0000313|Proteomes:UP000019114}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NF135/5.C10 {ECO:0000313|EMBL:ETW42055.1,
RC   ECO:0000313|Proteomes:UP000019114};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Plasmodium falciparum NF135/5.C10.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KI926053; ETW42055.1; -; Genomic_DNA.
DR   AlphaFoldDB; W4IG08; -.
DR   EnsemblProtists; ETW42055; ETW42055; PFNF135_03553.
DR   UniPathway; UPA00109; UER00182.
DR   Proteomes; UP000019114; Unassembled WGS sequence.
DR   GO; GO:0003872; F:6-phosphofructokinase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.450; -; 2.
DR   Gene3D; 3.40.50.460; Phosphofructokinase domain; 1.
DR   InterPro; IPR000023; Phosphofructokinase_dom.
DR   InterPro; IPR035966; PKF_sf.
DR   PANTHER; PTHR43650; PYROPHOSPHATE--FRUCTOSE 6-PHOSPHATE 1-PHOSPHOTRANSFERASE; 1.
DR   PANTHER; PTHR43650:SF1; PYROPHOSPHATE--FRUCTOSE 6-PHOSPHATE 1-PHOSPHOTRANSFERASE SUBUNIT BETA 1; 1.
DR   Pfam; PF00365; PFK; 2.
DR   SUPFAM; SSF53784; Phosphofructokinase; 2.
PE   4: Predicted;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777};
KW   Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ETW42055.1}.
FT   DOMAIN          86..243
FT                   /note="Phosphofructokinase"
FT                   /evidence="ECO:0000259|Pfam:PF00365"
FT   DOMAIN          598..865
FT                   /note="Phosphofructokinase"
FT                   /evidence="ECO:0000259|Pfam:PF00365"
SQ   SEQUENCE   1056 AA;  123827 MW;  40378C5D129AFB7D CRC64;
     MEDNNNICEI LKNYVQEDKI YKPYNIIDNN KTCVSNENKS NNNIPYDNIQ SYNMSYDNIS
     TYDFTYDNIS DISDEEINKK YPKKNKSFVK TSIVSAPTCV YNEMKNKYIE CSLGFDTTIF
     SYCQYISYLI THIQTYLQGY HFIKVMGNSS SHIALECFLQ TKVNIILVTE EIKKNNLTLD
     QIIQFIVDVI QNRYKKYHKN YGIVIIPDGI LKKITQFKKL VTSIIHIKTK FIENKINILT
     DLQNILSKHL IKEQQEFFKT LPDFFQIQLL EEICSQQFHY ARLSTELLLT HLVKKKLEER
     QINDLEFHTH SYGKEVTCSL PTNFDCAYSY ILGFSCVEML QHKYNGYMCV IKKLKNLLLN
     VNDIEILGIP LCHIMKIKKK NKNVAQINIV EQFFIKRTKV NLKDDAYFIK YKKYRYMYLY
     EDHYRVLTGI QYEHNFCIDY DDKSLKFRNK LNSTLSSNDY ITIKPNNIFS KINFTISGLT
     KEYFNKKEHN EEKSSMTQNN ILQNGVILQN NNTYKFNYCK HSSMLSEIEK MLTASAIKFN
     TILIRHNTRI TYINNNFFNK LYTISFIHIP KIKDFYILQD NQFHLKQNYR NVTCPKNVGV
     VLLSHCTPGT NNILVGLHQR LSINNFKLIG FIKGLKGLLN NDICLINDNN LKTSINIGGF
     PLLGVHIQYE KKTNDDQILH IHDLIKENNI SKIIKSCKNN NITNLVFIGD EKVITLMNIL
     NDIFINKDVN IKIVSIPISL YNSFDKNLIE CSIGYHSMVR HISDIISNVQ SNCLNINTYY
     YFIKIHTNIS SSLILSVQLQ THCNICYIGE SLNNQLTSLH TVIENISLII IERINRMKYY
     GVILFSSNLI YYINDFHELC KDVDENIKNV QEIDEIVKND ILPERFQKIL KKESVDLLNL
     LTESMKDKLL RKEKRENEDI DSNFEVMLIN EIKKYIQNLM EKSKQNKELY CYKKHMNTIS
     SPINVKNIKV YSDIDYILHF QTLIKVIDRE INCFFPTHFD NSLAFSHGLL AGIAVENDLL
     NYVTSIKHLN LNKQNWSRPV QYSVNPDNLG YSSYIF
//