ID   W4IJB7_PLAFA            Unreviewed;       358 AA.
AC   W4IJB7;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   22-FEB-2023, entry version 43.
DE   RecName: Full=GPN-loop GTPase 2 {ECO:0000256|RuleBase:RU365059};
GN   ORFNames=PFNF135_02594 {ECO:0000313|EMBL:ETW43119.1};
OS   Plasmodium falciparum NF135/5.C10.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=1036726 {ECO:0000313|EMBL:ETW43119.1, ECO:0000313|Proteomes:UP000019114};
RN   [1] {ECO:0000313|EMBL:ETW43119.1, ECO:0000313|Proteomes:UP000019114}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NF135/5.C10 {ECO:0000313|EMBL:ETW43119.1,
RC   ECO:0000313|Proteomes:UP000019114};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA   Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA   Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA   Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA   Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Annotation of Plasmodium falciparum NF135/5.C10.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ETW43119.1, ECO:0000313|Proteomes:UP000019114}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NF135/5.C10 {ECO:0000313|EMBL:ETW43119.1,
RC   ECO:0000313|Proteomes:UP000019114};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA   Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA   Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA   Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA   Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT   "The Genome Sequence of Plasmodium falciparum NF135/5.C10.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Small GTPase required for proper localization of RNA
CC       polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly
CC       step prior to nuclear import. {ECO:0000256|RuleBase:RU365059}.
CC   -!- SUBUNIT: Binds to RNA polymerase II (RNAPII).
CC       {ECO:0000256|RuleBase:RU365059}.
CC   -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC       {ECO:0000256|ARBA:ARBA00005290, ECO:0000256|RuleBase:RU365059}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KI926045; ETW43119.1; -; Genomic_DNA.
DR   AlphaFoldDB; W4IJB7; -.
DR   SMR; W4IJB7; -.
DR   EnsemblProtists; ETW43119; ETW43119; PFNF135_02594.
DR   Proteomes; UP000019114; Unassembled WGS sequence.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd17871; GPN2; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR004130; Gpn.
DR   InterPro; IPR030231; Gpn2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR21231:SF3; GPN-LOOP GTPASE 2; 1.
DR   PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR   Pfam; PF03029; ATP_bind_1; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|RuleBase:RU365059};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU365059};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU365059}.
SQ   SEQUENCE   358 AA;  41647 MW;  6419C2A67F45BE05 CRC64;
     MWYGQLVIGP PGSGKSTYVA GVTHILKQIN RKTVIINLDP FIENDIYEAD INISDLIDIE
     KVFSDMGLGP NGTLIYCMEY LLINIDWLEE KLNTYKDCYL IIDTPGQVEL YTHNDALKNI
     ILRLNKLNCR LTSVHIVDST LCSDGYKYIS SLLLSLCSQI HLELPHVNVF SKIDLLKYFK
     NDLKFPLSYY VEAQNLNQLI LYETYKNGSS SEDENLSYNY NKNLNNKTTN TNVENYNKNV
     MGKDNINYNE LKQDPFLYDI IKNEKKNYKK YSNKFLKLNE YICETVEDYN LINFALLDIQ
     DKFSVLKLLK IIDGANGFRF TSIYSEYSLF DTYVENVEYD CDEIEEKIMA TSDEDEKK
//