ID W4IM87_PLAFA Unreviewed; 1662 AA.
AC W4IM87;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=Leucine-rich repeat protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PFNF135_01475 {ECO:0000313|EMBL:ETW44225.1};
OS Plasmodium falciparum NF135/5.C10.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036726 {ECO:0000313|EMBL:ETW44225.1, ECO:0000313|Proteomes:UP000019114};
RN [1] {ECO:0000313|EMBL:ETW44225.1, ECO:0000313|Proteomes:UP000019114}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF135/5.C10 {ECO:0000313|EMBL:ETW44225.1,
RC ECO:0000313|Proteomes:UP000019114};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum NF135/5.C10.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW44225.1, ECO:0000313|Proteomes:UP000019114}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF135/5.C10 {ECO:0000313|EMBL:ETW44225.1,
RC ECO:0000313|Proteomes:UP000019114};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum NF135/5.C10.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI926031; ETW44225.1; -; Genomic_DNA.
DR EnsemblProtists; ETW44225; ETW44225; PFNF135_01475.
DR Proteomes; UP000019114; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR025875; Leu-rich_rpt_4.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR15454:SF56; LRRCAP DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR15454; NISCHARIN RELATED; 1.
DR Pfam; PF12799; LRR_4; 1.
DR SMART; SM00365; LRR_SD22; 5.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 3.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REGION 410..522
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1045..1072
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1124..1158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 764..791
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 997..1027
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1425..1483
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 410..439
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..493
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..522
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..652
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1128..1158
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1662 AA; 196341 MW; B391B5D0A3494699 CRC64;
MLLDLSNNKL KSLEDCDIIL EKLIELNLDY PSITYLNVSH NNIKSIKGLR AFENLRVLNI
SHNEVISLDD DYIPCCTEKI IADHNLLTDI CFKGIEKVEE EYDEDICEEN NSYEKCNNEN
VYKGNDNDND DINCNNNFYC DEDDNILCGK DIIKNKTKNY KKNNYHNEQE KRNQHNNNHE
KKKVTRNRSI YDSFNSNILN EKNMYTNKNL PLNKLIYLDV SYNNIKKLTT FEKYLHIINK
NKREKNDSCS DDAYMNNFIS NKTEQDVMIL FFNSLETLHL RGNQLTNLKG LSVFKNLKVL
DLRSNFINHP VQLFYILDNK NWLKKYQKNK MERKDTNYYS YFVYILKKYK NFKNLQNLFL
QGNNKVLKPK YLFMSVYNVL KNINVKRKLS TDVITDNLSL DVSKKKKKNN FVHNGESDDE
RNEAGRYVDC EGENKKYDEV EEGEEYEDEN EGEDEGEDEG EDEGEDEGED EEEDEEEDEE
EDEEEDDDFI NYVEEENYSL NPKNKKKGTE LNDRLEEKEI LDEKIKKDKV DDHNINEYKE
NIKNCPNDRD EEESFYEDDS SNEYTYIMEK MGKSFNKINK LENNKNTNNY LSDITYEEKE
VYDDTSQDNG ESNINRSSKC SPLYSEDDTE IESNEEEEYA LIRKRNNKEN EEEGYDGDDN
NKDGDDNNND EKKVKEKDKS LFIKDTFNNK NLYSCKTREK KFLYSINEDE DEKKIDDLIK
HISYNVSRNS SNIMSSQNSW KKNQECIKLK SCDNNKREFV WDNNQTEENQ VQNKNRERDN
IKKKILNTKE KNYISEESNV SYVEKANNCK KNIYKYIKSN DNINKSLVKE KKKNIFPSCE
RHNEEYLNEK INNRNTNNNI NINHENNNIL NTKERCSYTK HCHKNDTENN KIKKNKMEIT
INSLHKTYKQ KEGRNICFPS VFKENKKTND VLKEILYKNR DMDKSTLTNF SSMEESDMFD
SDCEEIMLTS NSDLININKE NMNKEKINKE NVNKEKINKE KINKEKINKE NMNKENMNKE
NMNKENIHMD DYNIHNCNIK ELSNFSDKNK NHSSSKQKGN SNPLTINYGK EDKYNMDDHK
KMIGTIEKMI EYKNSKEKGI IDDGDICISK QENAQGIFNE KRNKEQLNKQ GTNGSMNGGT
NGSRDGGTNG GTNGNMNGNK DKYQMEDSLY NDEEKKEVCN ILNISYRKNK TNYCDDNNLK
TEKCNIQRNV KNEMNISYSN QDICIYKIEE GKENVTYKCN NKNKLPMSNP QNRKLYHACS
SFKSESTDVT ERTMNMDKKL IIKKNILNND SLNINNMKNI KDLIISKNMM NIQQAYPIHI
QNNKETKNWN KKEEHDHNMS SIIKDTLLVE KKKVPKNEDI NDYINEKKNQ SIIKRNDLSQ
NNHKGTCIKN VQDVNILKDT EKYNDKNSML CNNLALYLKD ACLNLGKEKQ YTNNLLEQKK
KLENEIKIMN AQKDIYKKKI KNLEKLCIEK NKITKKYKNM NNTFKSFEHM KIEVPKGDMH
SQNEYIENTM EKLYNVFFDA FGEEHIITKM IESLADVYIK KEKNTEMKMI EHKKELDLLK
NVEEIVKKKD QYYNELLKKN EIIKSLNINL NNITKSVADM KKSIIENENK SRALLMELSK
KDSILKDMEK KILLMKGKEK EFEIERAKIM ELLKDNGKKG RT
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