ID W4INU4_PLAFA Unreviewed; 1297 AA.
AC W4INU4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=PI3K/PI4K catalytic domain-containing protein {ECO:0000259|PROSITE:PS50290};
GN ORFNames=PFNF135_00896 {ECO:0000313|EMBL:ETW44684.1};
OS Plasmodium falciparum NF135/5.C10.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036726 {ECO:0000313|EMBL:ETW44684.1, ECO:0000313|Proteomes:UP000019114};
RN [1] {ECO:0000313|EMBL:ETW44684.1, ECO:0000313|Proteomes:UP000019114}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF135/5.C10 {ECO:0000313|EMBL:ETW44684.1,
RC ECO:0000313|Proteomes:UP000019114};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum NF135/5.C10.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW44684.1, ECO:0000313|Proteomes:UP000019114}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF135/5.C10 {ECO:0000313|EMBL:ETW44684.1,
RC ECO:0000313|Proteomes:UP000019114};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum NF135/5.C10.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI926025; ETW44684.1; -; Genomic_DNA.
DR EnsemblProtists; ETW44684; ETW44684; PFNF135_00896.
DR Proteomes; UP000019114; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF22; PHOSPHATIDYLINOSITOL 4-KINASE BETA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 2.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777}; Membrane {ECO:0000256|SAM:Phobius};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 461..480
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 852..1282
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 105..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 931..971
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 941..956
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1297 AA; 155590 MW; 86E67AFB70B8B59F CRC64;
MNNKNEEFDQ GLSNKKEIKK KNNKIIKKNK KKKKINDISL INFQNYKILR DNYKKKINKK
LKKKKKELYY YKNIYYNVKK KKSIYNKKNK WNKFFSNILF FKHKKNNRQN NNNGIINNKK
KINNNNNNNN NNNNNNNNNN NNKNNNIHNN LHRYHYKKST INKNIGINNL FVKYQSKTIK
NKNINKLLKL DTDKDENIER IKHLFITFNY NKEKKINNYI HNIFTYTSLY SNFNICPKKN
IDILNYHIKV RRNLLKLLYS IYYKHNLSVI YKIYKKIEYI YTYLNISFYN NLYEFNMKDI
NENIDIYSLF LIIKYLKYHI YSNEKLFNTF IVLIINFINT NIHKVTNFLC MYDYSDLLNI
LNHYIINIDI NNKLTFNKYN LYILRKNKIT YVPISNILFL HCNQFRLNDI IKILYSHPQY
TLFLKTIAIN NLLYLYKKNT ITNTMYLQLF EYLKVDLGNR IFFFIIFFSF HSFQFLYQFF
MNMQSYIRNE YIGNDIIYYN NPNNFNKEQT ENKNIVHKYQ QTHDKSLELA LNTNHDHKEN
NMLCIHENNT MNDILFKKEL FVKKKNFFKD FFLFFMVKKN SLLLLSNDYK DKKNTNNIIN
INNFIFYKYQ GYVKKTHVLS LKCSLIKKLF LENLHDKYKN MLFESCCFHN TIFCISQQAS
KLNKDIQMDY VKMEIQNLIN NTNINKLKLL TSNNMVKNVS DNIKILMSAT RSPLFLTFKT
IPPSLNQLLF VHPFVQNNHT QHNYININVH NIDQLNIYTN NELYNQQVNK NILNNVTFVN
AQEFAQTNEP NNNQYINNVK CNSYSYVVNR NENNENTING MNCSGKIMGK NENNENKENT
TNDMNCSGKI MEENEMNEKE DNDEEKEKTF EDISYIYKVN DDVRQDKLVI QTIYIFIHIL
NEYKLCYNLF PYNIITNKFV NIYSSNEEDE KDEKKWTIGA SQKKEKKKRK NKSATTPKKN
NKVPNNDDQI DDKRKFSFSF NLFKKKRQGK NIYNKEKGEK NKEKINTGIN VNINNDDKIN
NMNHEVIIQN DTLLNVKNCN THKDEDKIVT YYENEDSVTE QEFIGHSRNM HISNVKKKKK
KKNKFENFGA VIEVLTNTKS RHDIGKKYQN IIKFYHLKYS NIIVYIYALK NFISSLAAYS
LLSFILQVKD RHNGNLLFDD NGNIIHIDFG YILNIYPGIS INFELAPFKL TREMIMLLTI
KSQKKQYFIF SYIQLVVKGY LLLREKSDWL ISSILSLSHS DINCFKYNTV EKLRKRLKLN
KNDNDASIFM INKIHQAYNN ITTILYDYIQ NIQQGIQ
//
