ID W4IQA8_PLAFA Unreviewed; 946 AA.
AC W4IQA8;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Peptidase C1A papain C-terminal domain-containing protein {ECO:0000259|SMART:SM00645};
GN ORFNames=PFNF135_00241 {ECO:0000313|EMBL:ETW45320.1};
OS Plasmodium falciparum NF135/5.C10.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=1036726 {ECO:0000313|EMBL:ETW45320.1, ECO:0000313|Proteomes:UP000019114};
RN [1] {ECO:0000313|EMBL:ETW45320.1, ECO:0000313|Proteomes:UP000019114}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF135/5.C10 {ECO:0000313|EMBL:ETW45320.1,
RC ECO:0000313|Proteomes:UP000019114};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum NF135/5.C10.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW45320.1, ECO:0000313|Proteomes:UP000019114}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NF135/5.C10 {ECO:0000313|EMBL:ETW45320.1,
RC ECO:0000313|Proteomes:UP000019114};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum NF135/5.C10.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
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DR EMBL; KI926017; ETW45320.1; -; Genomic_DNA.
DR AlphaFoldDB; W4IQA8; -.
DR EnsemblProtists; ETW45320; ETW45320; PFNF135_00241.
DR Proteomes; UP000019114; Unassembled WGS sequence.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02619; Peptidase_C1; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF642; PRO-CATHEPSIN H; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136}; Signal {ECO:0000256|SAM:SignalP};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..946
FT /note="Peptidase C1A papain C-terminal domain-containing
FT protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004843294"
FT DOMAIN 525..776
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
FT REGION 23..99
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 825..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 308..335
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 41..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 946 AA; 109685 MW; 16C0C3281FF5FC88 CRC64;
MVYRLFIILV LYVICCTNVI VGQEKPPPDS TVGANPGDER ESSGRVNNPA SGEQGTTNSP
TEQPDQTRDR SSSVPQGSPR EPVSPENPNP VTQIPGNGGA LVTPIPLPKL TLEDSESSKS
VTDIEVKSAL LKNYDGVKIT GPCRSYFRVM LVPHITVYVY ATYDRIQLEP KFGPSDLIDI
NDLTNKCNKD SNKYFKLVLY IKNNILILKW KVQDKDSKPT NIDVDVKKYK IPKLDRPFTS
IQVYTVNTEH GLIESKNYDI NSEIPEQCEA ISTNCFLNGS LDVENCYHCT LLAKKVDSNN
ECFNYVSKEA KELINKNLEE KNKTFKGEDE DLDSNEQKLE ESIDNILSNI YKIYESKQDK
ERKKSHYNNK KELVTIEELN SVLKIELLNY CKLLKEVDRS GMLDHHEIGN EIDIFNNLIR
LLKAHPGEST YVLNEKLRNP ALCFKNIEEW LVNKKGLLLS NEKIQNLSTT NYNVTDLEES
EYDYERFISD DMFEKDMNGV IDLSLFDNEK KLKSPYFRRN KYCNNEYCDR WKDKTGCISK
IEVEEQGNCG LCWIFASKLH FETIRCMRGY GHFRSSALYV ANCSDRDSDE ICFVGSNPVE
FLEIVEETGF LPLESDVPYY YTDAGNDCPE PEKNWINLWG STELLNHKRP RQRMTTKGYI
SYESSYFSDN MDLFIKIIKR EIQNKGSVIA YIKTENVIDF DFNGKGVHNM CGDKEPDHAA
NIIGYGNYID EEGEKKSYWL IRNSWGYYWG DEGNFRVDMY GPSYCKYNFI HTVVVFKVDL
GIIEVPKKEK ESEYFSYFLK YTPNFLYNLF FNNYTTNDEY KLNNRLKTNQ HNNKKNKKDR
YISAQDEPPT DNVESQEENN KKTEIYHILK HIKDKKIKRG LVKYESLLET KKDHSCSRTH
SIDPEKHEEC NQFCIDNWKA CKDHYSPGYC LTKLYTKDDN CFFCNV
//
