ID W4IS05_PLAFP Unreviewed; 877 AA.
AC W4IS05;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|PROSITE:PS50166};
GN ORFNames=PFUGPA_05516 {ECO:0000313|EMBL:ETW52509.1};
OS Plasmodium falciparum (isolate Palo Alto / Uganda).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=57270 {ECO:0000313|EMBL:ETW52509.1, ECO:0000313|Proteomes:UP000019103};
RN [1] {ECO:0000313|EMBL:ETW52509.1, ECO:0000313|Proteomes:UP000019103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW52509.1,
RC ECO:0000313|Proteomes:UP000019103};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum Palo Alto/Uganda.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW52509.1, ECO:0000313|Proteomes:UP000019103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW52509.1,
RC ECO:0000313|Proteomes:UP000019103};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Palo Alto/Uganda.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the importin beta family. Importin beta-1
CC subfamily. {ECO:0000256|ARBA:ARBA00010907}.
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DR EMBL; KI927388; ETW52509.1; -; Genomic_DNA.
DR AlphaFoldDB; W4IS05; -.
DR SMR; W4IS05; -.
DR EnsemblProtists; ETW52509; ETW52509; PFUGPA_05516.
DR OMA; QQYQERW; -.
DR Proteomes; UP000019103; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR PANTHER; PTHR10527:SF1; IMPORTIN SUBUNIT BETA-1; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000019103}.
FT DOMAIN 24..104
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
SQ SEQUENCE 877 AA; 99964 MW; FF628DD58E3A2C67 CRC64;
MESSNIGQIL YATVDPNINI RSEAENKLKL AKESNFVQYI NQLSNEFCKS ENDPYLRQIA
GLLIKNAFTS KDNYESEEKA RTWLNFPEDI KMELKNNLLV LLSQQSDKIV IGTACQIISI
IAKIELSHNK SSELLHKLVN NIIEKNAYTK KSSTVCLAYL TEDIADVCNE SKSKYAFTQP
DLDLILTAII NSLCEPAEES THCANMKVLY NLMSFIEHNF KTQVERDIIM KTVIDGCKDT
ERQSVQIAAY ECLINIVSYF YSYLDAYMYA IGPLTWVAIE SENERIAISA IEFWNTVCEE
ETFIDQYELQ EGKKNHNIVK QAMVFLLPKI FNAMITQESE DIDIDAWTLS MASATFLALS
AQLLKNDIVE PVISFVEENF IHEDWRRRDA AVLAYGSIME GPDTEKLKPL VEESVGQLSE
VLRDPSVAVR DTAAWTIGKI TTYHSEIIYN VLGSYNDSNS LYGILLERLN DYPRVAANVC
WVFNQLAVNK RTSYNKMTNS YVTDLDDSFC VLCKKLIDVS SREDSDIRNL REAAFNALNV
VILSVSDNCL KYMIELLSHM MYLLTNTYLN PLTEEVKSLQ GYYCGTMQFI INRLGNQCKP
FLKPIYLSIF RLFEIRTDIC EDALLACSAI INVMAEDFRE HLKTFLNVIF KGLKNVSETS
TCKICIEMIS DICIPWTSEY EKEMEAILEC LWEALKTFGV HDSIKISILT VLGDIATALN
RSFSKYLNFF ANILSETSKI TITSGSPDSD DWVNYVFELR DAILLTYSNI IYALIDGNEI
NKLKPYIPNI LDFIELILIK EINHFNAQNF QNSVSLLGDL VHAYGYELIE NSKLTDLIIS
VYGKIDILSS QGDEKCETCV SKIKWLKRIC NARLSQK
//
