ID W4ITE2_PLAFP Unreviewed; 735 AA.
AC W4ITE2;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Glutamyl-tRNA(Gln) amidotransferase subunit B {ECO:0008006|Google:ProtNLM};
GN ORFNames=PFUGPA_04675 {ECO:0000313|EMBL:ETW53049.1};
OS Plasmodium falciparum (isolate Palo Alto / Uganda).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=57270 {ECO:0000313|EMBL:ETW53049.1, ECO:0000313|Proteomes:UP000019103};
RN [1] {ECO:0000313|EMBL:ETW53049.1, ECO:0000313|Proteomes:UP000019103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW53049.1,
RC ECO:0000313|Proteomes:UP000019103};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum Palo Alto/Uganda.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW53049.1, ECO:0000313|Proteomes:UP000019103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW53049.1,
RC ECO:0000313|Proteomes:UP000019103};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Palo Alto/Uganda.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) +
CC L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate;
CC Xref=Rhea:RHEA:17521, Rhea:RHEA-COMP:9681, Rhea:RHEA-COMP:9684,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:58359,
CC ChEBI:CHEBI:78520, ChEBI:CHEBI:78521, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00000924};
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DR EMBL; KI927386; ETW53049.1; -; Genomic_DNA.
DR AlphaFoldDB; W4ITE2; -.
DR EnsemblProtists; ETW53049; ETW53049; PFUGPA_04675.
DR OMA; VFFNDPF; -.
DR Proteomes; UP000019103; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016884; F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor; IEA:InterPro.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR InterPro; IPR017959; Asn/Gln-tRNA_amidoTrfase_suB/E.
DR InterPro; IPR006075; Asn/Gln-tRNA_Trfase_suB/E_cat.
DR InterPro; IPR018027; Asn/Gln_amidotransferase.
DR InterPro; IPR003789; Asn/Gln_tRNA_amidoTrase-B-like.
DR InterPro; IPR014746; Gln_synth/guanido_kin_cat_dom.
DR PANTHER; PTHR11659; GLUTAMYL-TRNA GLN AMIDOTRANSFERASE SUBUNIT B MITOCHONDRIAL AND PROKARYOTIC PET112-RELATED; 1.
DR PANTHER; PTHR11659:SF0; GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT B, MITOCHONDRIAL; 1.
DR Pfam; PF02934; GatB_N; 2.
DR Pfam; PF02637; GatB_Yqey; 1.
DR SUPFAM; SSF89095; GatB/YqeY motif; 1.
DR SUPFAM; SSF55931; Glutamine synthetase/guanido kinase; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000019103}.
FT DOMAIN 211..313
FT /note="Aspartyl/Glutamyl-tRNA(Gln) amidotransferase subunit
FT B/E catalytic"
FT /evidence="ECO:0000259|Pfam:PF02934"
FT DOMAIN 371..539
FT /note="Aspartyl/Glutamyl-tRNA(Gln) amidotransferase subunit
FT B/E catalytic"
FT /evidence="ECO:0000259|Pfam:PF02934"
FT DOMAIN 578..692
FT /note="Asn/Gln amidotransferase"
FT /evidence="ECO:0000259|Pfam:PF02637"
SQ SEQUENCE 735 AA; 87564 MW; 2293CCA49DC5D7A6 CRC64;
MLIIQYHSFI TCFNINHITN NNILLTPTNT CLLKKGRKNE YLNFYCDGMG QVKKHGYALR
KNAVFFGDIR NKEIEENTVS YIDKNVKCKI GLEVHIQLST KYKAFCNCFN ISSLYGEKTY
EKNHNDLIDF IREKNDQLSN DQLSNDKVNN EQLPNDHVHN DHVHDEQAHN DKAPHEHKNI
RQSIFNNQTR IKKDLIKNNT SDDIVIKKYH NNENMEPNKY ICNTCIGEVG SLNTLNSTAV
LFSYLISTIF NCNLNNNISF DRKIYNYYDL PKGYQITQKD NPIGYDGYIF LNEKKYDIKS
VHLEEDTSKC YLHFSQKNEE GKNFNDNHKN IEKHDNDTIH DINTNHNNIQ NFNIHSEIIN
NEHYVTNNKN QIHIKPHKIL LDYNRCGVPL VEIVVEKAYM NSEECINLLK EIKNKVCLLG
VCVGNKENIR SDINISFEYG NIKNDRTEIK NINSFTKIRN YIETERTNFI NYIRKNIINN
DIGSDHIHNR DNINTFWSNN NIYTKSYIDN THFILRKKEA YNYVKEGNIP KYRINDNILK
LLKFYVNYKI KIYQDEKKYN WSKHYFHVFF NDPFLYNYFN ECLKYEQEKY VSNFLVNILL
DILKKKNILS KQILIKPKDL CFLINYAHTN NIDNTFLKSF IFQFIDKEFK REDFYEQLKH
INANDIEHTL IELIKQNKHY LKYDQNKMSI INQQNFKNRI IGLLKNKFNV HTSNVIINYK
HVNDFILNYI NKHLL
//
