ID W4IVE0_PLAFP Unreviewed; 1432 AA.
AC W4IVE0;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=PFUGPA_03813 {ECO:0000313|EMBL:ETW53940.1};
OS Plasmodium falciparum (isolate Palo Alto / Uganda).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=57270 {ECO:0000313|EMBL:ETW53940.1, ECO:0000313|Proteomes:UP000019103};
RN [1] {ECO:0000313|EMBL:ETW53940.1, ECO:0000313|Proteomes:UP000019103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW53940.1,
RC ECO:0000313|Proteomes:UP000019103};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum Palo Alto/Uganda.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW53940.1, ECO:0000313|Proteomes:UP000019103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW53940.1,
RC ECO:0000313|Proteomes:UP000019103};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Palo Alto/Uganda.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
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DR EMBL; KI927384; ETW53940.1; -; Genomic_DNA.
DR EnsemblProtists; ETW53940; ETW53940; PFUGPA_03813.
DR OMA; VHLIRKH; -.
DR Proteomes; UP000019103; Unassembled WGS sequence.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF72; ATP-DEPENDENT DNA HELICASE Q1; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000019103}.
FT DOMAIN 60..230
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 264..418
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 714..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1432 AA; 168611 MW; F7D5AD673DA12BA9 CRC64;
MLKFLNVKSP VVSSDVDEIT DDSDKGDVSY TLEELRMKME ITQKKHFGYK NLKDFQVEAV
HATFHKKDSF IVMATGMGKS LCYQIPSLMD VCRKKFTIVI SPLISLMKDQ VDNLNRKRIS
SVFLGSGQKM NNNKILNEIK HGIYKIVYCS PEYALNNKDV FILLKNRILL IAIDEVHCMS
EWGHDFRPSY RKLNELRIIL KEIPIMCLTA TCTKNVQSDI LKNLNFDLQN CLIKRSSVNK
KNLFYSVREK TDIYHDLKDI LDIPLKESIE RTKKFIDNSK ICSYNSTLIY VNSKKECESV
YSFLKEKGLL VLMYHADLTN DQKKEAHEKF LKDEIQIIVA TVAFGMGIDK PDIRRIIHYG
FARSLEAYVQ QVGRAGRDNS DAEAILFFHI NDESKIKNII LRENTANNLI ETNFQRVEHI
VHIFTQASDY AYSTACRRKK IYEYFDEAPL TSYDIDIFND KRNEGICYYI KKYDIYLCGK
CDNCVYCLNL IKKKNGIKTN KINNNNINIY SNSNNNNNIN SNNNSREYYL DNDIKKETSL
KSLTCYYISS SSNSSFSSYI FDNVVDLTNE LKTLLNCISS LKGKTGLSTV CKILVKSKES
SIIKKNYHNI KEYGKGAHKS TNWWSSFMKV VRNDKFIKET LNCGKEMCYI SVGVTDKGEE
FIQSKEKYII ALPFFLNTSP KSSNTRNKKT KKDTYGKYSN NKETKYENIT YEYKDKYNDN
DNDKDNDNDN DYSKDIYNVD DYKYDDHHIS SKIKQQQEQH NNNIRDIYYN DKDVEYDKSI
HNINKNTNKN LSYITIESGD EKGNTNCIIN KENINRDNNF EKTHKNNIEK YEYIESYQKQ
KNNNKNNNIQ INNKKYDDNK YEYFNINKND FIMKENRYTK EEKILSDEQI NDSIMKILLR
TRMLEARKQN IPPFQLISDQ PLKDICHKRL TSVELIRKHV YNISPICPNT FLEKIVSGIR
GFCLLHDLKT DILNLNIYNP NHNNSPIPIN AKTSTLKNFE NLISSYNYYD RNKYAPREES
KSNETYSYEH YTGTERKCKH FVTQEDEYNH ADISKMSRHT NIYEHKKNMN DHTYDLHNYN
NNITYDYGDI PKNTLIQYKN SLTDQNTISM SDINSDNKNM VYNNHIFNKN HSIITNYNSS
AENNSSLQNE FYRKKTNIID DNNIGHHTYN INDNYHTNDV LLTNAIIKDR PKKKHDDIFS
NFCYKRDESE TGVQGNVTHV KKDINKGYQE NKNDITFLQN NISQHTNNMI HNNGKDVKNN
LSALDDDDDD DDDFKFINQI QTLGLHEQNC KEENNYQNSL TNEHVHIPNY NLYQEENTRN
ENEKRKININ LKQEDQNIYT KRHQYLTNPN EHSVNNMHNI HLKENNIPNY DYTNQNVHES
NQKKNDFYEE KKKKFNFIES FSYNNNQEDK KRVNNLDILD QFVYRDVKKR KT
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