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Database: UniProt
Entry: W4IY07_PLAFP
LinkDB: W4IY07_PLAFP
Original site: W4IY07_PLAFP 
ID   W4IY07_PLAFP            Unreviewed;       912 AA.
AC   W4IY07;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   07-NOV-2018, entry version 22.
DE   RecName: Full=DNA ligase {ECO:0000256|RuleBase:RU000617};
DE            EC=6.5.1.1 {ECO:0000256|RuleBase:RU000617};
GN   ORFNames=PFUGPA_03462 {ECO:0000313|EMBL:ETW54860.1};
OS   Plasmodium falciparum (isolate Palo Alto / Uganda).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=57270 {ECO:0000313|EMBL:ETW54860.1, ECO:0000313|Proteomes:UP000019103};
RN   [1] {ECO:0000313|EMBL:ETW54860.1, ECO:0000313|Proteomes:UP000019103}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW54860.1,
RC   ECO:0000313|Proteomes:UP000019103};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B.,
RA   Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA   Abouelleil A., Allen A.W., Alvarado L., Arachchi H.M., Berlin A.M.,
RA   Chapman S.B., Gainer-Dewar J., Goldberg J., Griggs A., Gujja S.,
RA   Hansen M., Howarth C., Imamovic A., Ireland A., Larimer J.,
RA   McCowan C., Murphy C., Pearson M., Poon T.W., Priest M., Roberts A.,
RA   Saif S., Shea T., Sisk P., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Annotation of Plasmodium falciparum Palo Alto/Uganda.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ETW54860.1, ECO:0000313|Proteomes:UP000019103}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW54860.1,
RC   ECO:0000313|Proteomes:UP000019103};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA   Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A.,
RA   Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J.,
RA   Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA   Larimer J., McCowan C., Murphy C., Neiman D., Pearson M., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Plasmodium falciparum Palo Alto/Uganda.";
RL   Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n)-3'-hydroxyl +
CC       5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) +
CC       AMP + diphosphate. {ECO:0000256|RuleBase:RU000617}.
CC   -!- SIMILARITY: Belongs to the ATP-dependent DNA ligase family.
CC       {ECO:0000256|RuleBase:RU004196}.
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DR   EMBL; KI927383; ETW54860.1; -; Genomic_DNA.
DR   ProteinModelPortal; W4IY07; -.
DR   EnsemblProtists; ETW54860; ETW54860; PFUGPA_03462.
DR   OMA; WIKYKRD; -.
DR   Proteomes; UP000019103; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:InterPro.
DR   GO; GO:0051103; P:DNA ligation involved in DNA repair; IEA:InterPro.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3260.10; -; 2.
DR   InterPro; IPR000977; DNA_ligase_ATP-dep.
DR   InterPro; IPR012309; DNA_ligase_ATP-dep_C.
DR   InterPro; IPR012310; DNA_ligase_ATP-dep_cent.
DR   InterPro; IPR016059; DNA_ligase_ATP-dep_CS.
DR   InterPro; IPR012308; DNA_ligase_ATP-dep_N.
DR   InterPro; IPR036599; DNA_ligase_N_sf.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   Pfam; PF04679; DNA_ligase_A_C; 1.
DR   Pfam; PF01068; DNA_ligase_A_M; 1.
DR   Pfam; PF04675; DNA_ligase_A_N; 1.
DR   SUPFAM; SSF117018; SSF117018; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   TIGRFAMs; TIGR00574; dnl1; 1.
DR   PROSITE; PS00697; DNA_LIGASE_A1; 1.
DR   PROSITE; PS00333; DNA_LIGASE_A2; 1.
DR   PROSITE; PS50160; DNA_LIGASE_A3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000617};
KW   Complete proteome {ECO:0000313|Proteomes:UP000019103};
KW   DNA damage {ECO:0000256|RuleBase:RU000617};
KW   DNA recombination {ECO:0000256|RuleBase:RU000617};
KW   DNA repair {ECO:0000256|RuleBase:RU000617};
KW   DNA replication {ECO:0000256|RuleBase:RU000617};
KW   Ligase {ECO:0000256|RuleBase:RU000617};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000617};
KW   Reference proteome {ECO:0000313|Proteomes:UP000019103};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     15       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        16    912       DNA ligase. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5012610283.
FT   DOMAIN      642    778       DNA_LIGASE_A3. {ECO:0000259|PROSITE:
FT                                PS50160}.
SQ   SEQUENCE   912 AA;  104540 MW;  31B5FD0EC415AE39 CRC64;
     MNFLILVVLI KMVVCKIINY VRSDYNFMLS FLRTRKIFSH KKIYFNFKVS KNFTKNSSSN
     SYSDILKCFS FPRKGTNDKT KENETFEKGE VKEEEEEKDK NVKRKIINES SKNKRAKVKN
     ENDVIKKGSL FNCVVREDEK VNDLSSPKFN PVHFNINDLY LSEKDKEKHK FKDSLLFTFL
     TNAFNQIEEL KGSGTGSKKN VSIILSNIFR VLIYYSPNDL IPAVYITLNK VAPDYLNVEA
     GVGEALILKT MSEAYSRTES SIKKDLQQIE DLGIIAENCS CKMRTIFPLP RLTIQSVFHE
     LKSIPNLIGS NSQQKKREVI KKLLVSAKTS EAKYIVRFLQ QRLRIGVNSA TVVQALSYAF
     ILTRPSIPDD IIKRGKEINE NLINGKLDGT NNLINKSNNK TEEWLTQSGD RNCIKEENLN
     DELLSKDDIN KCENMDSLIN EIRIRNEKIN KPNIFYNLIE KVGDTRLLPL FFKELKNIYC
     EENNDIDIFE CMEKSVKSAL CELPNIEIII QNLLNGDDMN TLSKKCTVKT GIPVQPMLAK
     PTKGVQEVLD RFNNVTFTCE YKYDGERAQI HYIDKDNIKI FSRNLETMTE KYPDVIQIIK
     DQIGENVKEC IIDSEVVAYD IVNNKILPFQ VLTTRKRKDV DIENIKVKVC LFPFDLICCN
     GIPVIKEPLA VRRKLLYSLL KSKDGVLSYA THSEMNNIED IDMFLQDAIE NNCEGLMVKT
     LVENASYEPS RRSLNWLKVK KDYVEGLSDS VDLVPIAGYY GKGKRSGVYG AFVLAAYNSE
     TENFQTVCKA GTGFSDEILS TLYETLSEKI IPNKKSYYEV SDKLNPDVWF DAHYVWEVKA
     ADLSLSPVHT AAIGIYADDK GIGLRFPRFL RLREDKNAEQ ATTTQQIVDF YEAQFSSNKN
     KNIDYNDDTE SE
//
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