ID W4J010_PLAFP Unreviewed; 2752 AA.
AC W4J010;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Guanylate cyclase domain-containing protein {ECO:0000259|PROSITE:PS50125};
GN ORFNames=PFUGPA_02549 {ECO:0000313|EMBL:ETW55389.1};
OS Plasmodium falciparum (isolate Palo Alto / Uganda).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=57270 {ECO:0000313|EMBL:ETW55389.1, ECO:0000313|Proteomes:UP000019103};
RN [1] {ECO:0000313|EMBL:ETW55389.1, ECO:0000313|Proteomes:UP000019103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW55389.1,
RC ECO:0000313|Proteomes:UP000019103};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum Palo Alto/Uganda.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW55389.1, ECO:0000313|Proteomes:UP000019103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW55389.1,
RC ECO:0000313|Proteomes:UP000019103};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Palo Alto/Uganda.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI927341; ETW55389.1; -; Genomic_DNA.
DR EnsemblProtists; ETW55389; ETW55389; PFUGPA_02549.
DR OMA; NNNKYHH; -.
DR Proteomes; UP000019103; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 2.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR43081; ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED; 1.
DR PANTHER; PTHR43081:SF1; PH-SENSITIVE ADENYLATE CYCLASE RV1264; 1.
DR Pfam; PF00211; Guanylate_cyc; 2.
DR SMART; SM00044; CYCc; 2.
DR SUPFAM; SSF55073; Nucleotide cyclase; 2.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000019103};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 56..78
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 881..902
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 914..933
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 940..959
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 979..1005
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1043..1063
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2312..2333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2345..2363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2383..2405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2444..2462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2468..2488
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1126..1278
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT DOMAIN 2541..2675
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 1692..1720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1930..1951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2149..2213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1935..1949
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2160..2185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2188..2213
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2752 AA; 326785 MW; A53835304D1C4F89 CRC64;
MKTQTLSLMN INGKRKFLGK NNKIYRKVII NPTSEDDIQK FCRNYFRIYN FSLYNFIRRL
ISFDAILVYS LFLTVYIFSE INHGETKKYL FIDTAISLFF NIILLIVIES LFELKKLKDV
KNANSQYYLR IVPKMSYFEK VMTKDIKVGN IIRIFQGDEF PADVVILYVK NNANAIVDSF
KIDGLFRKSI KYAVDKYKID KDYLKMLSEI NGVIRCELPN KNIFCFQGNF KLDKHPRSLL
LNYENFALQS YLHKKEKYAY IYIYIYIYIY LYIIYIIEND LRMRNTDSEK PKVFNKNKND
SLGNVDLLAT SRNGVLVKRK ELLVSCVINN VMYGKKDIIC SRTNFKLPTL NILDSERKNV
SNLLNLDERI FKDPENIFFP TRDFYSFLKL FENKISSIYN PYSSSLSNLL KEKYKNYVNE
EILNKNVKLT SFVKSQLTIG YNQICEDDEL SYNCYEIKED SQKENIQSVK IEDFILGLCG
CNRIIIYNEK SLDISMNEYK SDNFMETYSK FETENEEYHE NDHDEYHNME HSDDENINSI
EYEDICLYNI IRNTGFSIYC YKNTLFLYNL MKECKVYFLT CYHDFLRSNK FSMCILKCGY
SINNEKEGGI LYVRGYDFNI LPYISKEKNN IKKIKNVIKI YTLNYLKVII LCKKQISNED
IAKYIILKSI SKKLSFKFYD LIKLFFLYDL EVIGIIGLKN QLREGVKETF NDVINFDIKS
WIFANECSKD TYLTALQCNL IVSSSNLFLI NYYNLKNTHE EGANILFHNF ISSLYKLKSN
SYAVVINDES IKNIMTNVES MRKIKGINKF VNFEKNDILL KYIPTPKIYK IKDDPTYYNK
SKRSKFLYDT FRKVIDINVK YRNQQLNLEY KTYEKGNKLK LRIIVILLFL IYIIIFSSQT
IIDINTKSNI HYITMFYIIY FVLACVLLIY IRIRNKATST FFYFLSRFLL ICGFCIELYD
NISNDILNVL ITYSFTVSYI FFMSFKILEA LLVCISILLL TFGVYYEKNK NMIDICTHFC
SNPYLSINNL DHMNISCLCK KQIVIFLISL LSFTLICLSM KYYEIFYLKK KFLFRYKQKV
NLAKQIEILH TMLPNFLVEY LLISDPKNDG IMVGKNISGE DRGIISVIFC DIDDFQNMVS
TLQPHVLVET LDNLYLYFDK CIKYFNCIKI ETVFESYLAA SGLSEKKNNA LDKIMYDTKC
AIKLAIAQLS AKYYISYKVL DTREHFSDNS TSYDKYINKN ISLKIGIHTG KAISGVIGSV
KPQYALFGDT VNTASRMKST SLPDHIHVSY DTYKYLKEDN TFIWKERKVF IKGKGKMKTY
LLVDILDDVK RKGESLNYYS SSNLLLSQLG SEAVSIYEER EDIKEGSMDI IKESSRDIIK
EDSRDIIKEI STNISKSSSR SISDIKEGQI IDKEDLIFKI NRMKNKIDSR YSKRIDKESR
DKISDKTNHV LDEVVKHSDI HLLNYEINNK RCKKMKGDTN NENKLIGDIF NMYDKKIKYI
YKKNYKSKSM ENISFIKHYR NTKYKKSDYL LLDNKGESKK FKRNTSYVLE SPLHLIGDIV
DNNIKRKKKK KEIKTIVSDD MFTSPVNIKE YNYNEQERKK EIVGNLSYDK TKKIFPFIKF
TKEGRIKKKK IEKKEKKENN NNFLYNDDYS SYSSPKYGDN ENNFVIKYIR ERKDFQKKFD
HPNFNFSKFL HNYNPMKNKN KNKKNNKNVR RNEYPNYTSS SKDGVSYNFL SDSLFSSDNE
YSSDNEYSSD NEYSSDSEKY YKKRFKKNKK IIKFDDLFTK IYIKKKRLLQ MNNYDVKGKG
KKLKNKGMER NKTKYKNVNE ITKMKYFVNN ENRDHEVNKE DISKSMQKYF LHISKHKKEQ
IEDKKKTHKY FHKNVECVYP YAGNNINHNF SRNEKRKYSI NLYDHLDEQE KIKGKKKYFN
KDKELIGSIN KQTERKPKKK NKKNIENKKD KKKIRMITNK NKEKHSNSII SVEEQNMNHN
NSLKKKEVNF TGKNEEYLNR ANTNCSLGIK EMEEDVYEFH SNNIYYNNQT SYSDDINNTT
KLKGMGNNTN DISKNKGKNK LGKKISFFSM NNKYHESEIM NEEDNKNMLN LTQSQIINKD
KYNYFTHCPS LKKKKSVFTK INNLFKSYFK SIDVHEKFGF SKKFKFHSKD SDDIKGNNNK
ISKNRYNNNN NNNNSNYSNI DSGKYSHNNK KNHHHNNNKY HHHNNNKYHH HNNNKYHHQN
NNYEKNHHSN NSRVMLSKGE KTEKNENVDY AYQFDNYDKK LLKKLTSNLQ LNKKNVKNFN
MFYYKFNDEE LEEEYTRNYY REIINIDLTK KLIIIFIFTE IFLSLCNIIE LSFYEKKLRY
NDSIVIIWLI RSIYLFIITY IWIILKTKLK EYKNNSSKMM WTIFILNIFL CSWGIILIDL
SCIHYSMLLG NKNERALFFM KDASELIICI QLIFIKNMLF KHKFFFFVFF YIFLIYSFSK
LFSIHTCQTH ICCSIILFIS INILYFWYSE YLDRIQFLVK RKRNRMEKIS QDFLTKILPR
QVLEEYQNDN LQLTYKHEKI AFLFADIVGF TKWSKTVSPK EVLKLLQKLI SKIDKDTIKL
GLYKLFTIGD AYVATSQPNS SITDESEALE GILNILKLAK LILHNINTIK IQFNKHDFNM
RIGLHYGSCV GGIIGSVRIR YDMWGLDVLI ANKIESNGIP GEIICSEQFR HFFIQNEPQA
KLNFWYYKSI SINDQDIKLY VIEDKNYEED YDPKVIDYTT LLKLRQKKGL RS
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