ID W4J0W5_PLAFP Unreviewed; 1618 AA.
AC W4J0W5;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ETW55913.1};
GN ORFNames=PFUGPA_01958 {ECO:0000313|EMBL:ETW55913.1};
OS Plasmodium falciparum (isolate Palo Alto / Uganda).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=57270 {ECO:0000313|EMBL:ETW55913.1, ECO:0000313|Proteomes:UP000019103};
RN [1] {ECO:0000313|EMBL:ETW55913.1, ECO:0000313|Proteomes:UP000019103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW55913.1,
RC ECO:0000313|Proteomes:UP000019103};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum Palo Alto/Uganda.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW55913.1, ECO:0000313|Proteomes:UP000019103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW55913.1,
RC ECO:0000313|Proteomes:UP000019103};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Palo Alto/Uganda.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KI927329; ETW55913.1; -; Genomic_DNA.
DR SMR; W4J0W5; -.
DR EnsemblProtists; ETW55913; ETW55913; PFUGPA_01958.
DR OMA; IAITTWH; -.
DR Proteomes; UP000019103; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140326; F:ATPase-coupled intramembrane lipid transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 2.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 2.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 2.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR032631; P-type_ATPase_N.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR032630; P_typ_ATPase_c.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR PANTHER; PTHR24092:SF5; PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR24092; PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE; 1.
DR Pfam; PF13246; Cation_ATPase; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF16212; PhoLip_ATPase_C; 1.
DR Pfam; PF16209; PhoLip_ATPase_N; 1.
DR PRINTS; PR00119; CATATPASE.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000019103};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..37
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 71..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 601..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 644..663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 670..690
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1431..1448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1491..1515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1551..1570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1582..1602
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 57..110
FT /note="P-type ATPase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16209"
FT DOMAIN 1385..1611
FT /note="P-type ATPase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16212"
FT REGION 244..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..486
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 837..859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 902..927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1023..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 982..1011
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 273..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 297..311
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..467
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1618 AA; 190446 MW; F69AC40DB02F639D CRC64;
MVDDEELRKL RFLLSNKGGR IKYFFSYIFY KLFSHIYNKK NKKRERFVNI HGRTFPNFFC
DNKIKSTKYT ILTFIPLFLF YQFADFLNLF YLCVSLLQII PIFNTGYVFT FVAPLLFIIF
ISLINEVVDD LKRFIKDLEN NNEIYYSLLE NGNFQKIYSK DIRVGDIILI KSKQRVPADC
ILLRNLNKNE ESNFKVEEKR LFNCFRWNKS NNVYNKINKS YYHFNKNIDN ELIDDRYNES
NNNCSETSNN LLFSENEKSQ KKGKKKQKKK LMLGDNNTNM NDFNFNPNDQ NNNMSNQLKK
KKKRKKKNNK SKKNININET TNETANYTYV KTDKIDGETD WKIKYPINIF QNLKRLKDFF
TIDILFILEQ PKNDIYKIEG SFVIFKYNPY GDFKTTENNN HSLNDNQLLN YSFDMAKEDE
GRVQDDEDVD EDDYDDDDDE DDDDDDEDDD EDDDEEDDDE EDEEVNIPNN EKNDTQNLDD
KKSVRRIFGT KNNTYSYGDD DQVQNEKKKN LDRGYLNLEE KDTDYAYNKK DKKKEMVTFI
DVEKGNNERT INLNKKKNSV NTTGNRSSYV NDGKMCNVFN NEDNFNFYNV NYRKKLNYDN
FILFNSVITS SDVICLVIYT GSDTRVNMST QISKIKRGMI DEKLNLITLF LFIILTLFSI
YMCSVKLNNL WYLNFIRFML LFSSVIPISL SVNLNIAKIY YTLLIQRDKE VESTIIKNSG
IIENFGDIDY IFTDKTGTLT ENVMVLKVIH IGFDVIHAEN EKNSIQGNNM ETKQKGNYNK
KMLSYNLDDM NEDVDDTSIY LASSNYSKHD RRNKNLRNGE LASFSYEMEN TSNINNNTKL
RNYTKSNHHH NNISDNELYD EKNYNDDQRS LSNYSDTSYG DVHLKNYKQN NMILNQNMGQ
NRNETLTKNN NNNNNNNNNN NNNNNNMSLE KKKKKVEKMV DEFLKYKSDP LDYYNDNIDD
IEYLKRHRVF QTFLSFLICN NIRTLTKESS NKEKEKTKKK KERKEKDFQK NLYYILKVNR
KKKDVQKNKK ENNSDNVKSS TQNKKKKHFS SNSSEDSETF SHSDVSYQCS SPDELAFLKY
ATNCGFILKK KTASKIEIKY KNIMLEYDIL LHIPFSSETK RMSIFVRNVK NRNIYFFIKG
ADNVLIKKCH EKYKTFIYEE SDHLSNIGLR VLVHGCLNVE EQFFHNFSAL YNKNKDVKGQ
LENILEYVEK NIKVLAITGV EDKLQEGVGK TIEMLYNSGI KVWVLTGDKI ETAICICKNA
NIKKKKHNIY IFRHENIKST SNLIREFNSI LHNIESYVLF FDNIIIQNCI KYIPNAFVDF
AANARAVVCC RCSPIEKKEI AILIKTIKKK KILCIGDGGN DVAMIQSADI GIGVLGKEGK
QVVHDSDIIV SKFKNIKKLI LYYGNNTFLQ TSSLCSFLIH RGFILTYLQF IYSYIFFSIP
VSIFQGWLQI GYTTYYTTAP FLSLLLDIKI KKNLIYLYPE IYKNKKHKRK LDLKSFFIIV
WISIFQGTVV MLGALKLFND NYNNLINISF SSLIVLEIMN IHLEVESWHP LMISANICSF
IVYIFSMFIL RNYFDIMQIM SVMFWYKVIL IVIFAWLPFF IIKKVKNIIT PSQFFKLA
//
