ID W4J1B1_PLAFP Unreviewed; 1724 AA.
AC W4J1B1;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=C2 domain-containing protein {ECO:0000259|PROSITE:PS50004};
GN ORFNames=PFUGPA_02174 {ECO:0000313|EMBL:ETW55839.1};
OS Plasmodium falciparum (isolate Palo Alto / Uganda).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=57270 {ECO:0000313|EMBL:ETW55839.1, ECO:0000313|Proteomes:UP000019103};
RN [1] {ECO:0000313|EMBL:ETW55839.1, ECO:0000313|Proteomes:UP000019103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW55839.1,
RC ECO:0000313|Proteomes:UP000019103};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum Palo Alto/Uganda.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW55839.1, ECO:0000313|Proteomes:UP000019103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW55839.1,
RC ECO:0000313|Proteomes:UP000019103};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Palo Alto/Uganda.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI927330; ETW55839.1; -; Genomic_DNA.
DR EnsemblProtists; ETW55839; ETW55839; PFUGPA_02174.
DR OMA; NIWYDYW; -.
DR Proteomes; UP000019103; Unassembled WGS sequence.
DR CDD; cd00030; C2; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR PANTHER; PTHR46436:SF2; C2 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46436; CENTROSOMAL PROTEIN OF 76 KDA; 1.
DR Pfam; PF00168; C2; 1.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR PROSITE; PS50004; C2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000019103}.
FT DOMAIN 497..623
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 16..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1193..1244
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1349..1370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1452..1513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1530..1554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1705..1724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1724 AA; 206029 MW; EF7DD72799799EC4 CRC64;
MILDKFKNIV NLSNSNTEKE EGKNAEINEN NDPNTQLAHE PSIVEADEKT FFDEMLGAPQ
YTYDEFLQVL KNPIEERGDT EDMKKHWGYP RRWKVILWDL HIQNYMNNDF NAFVDFDFGG
NREECRIQRG STMKIYAKGK TKNCLRTPVV TNVATEQKKN MNFRNVFEYR GSYLDLENEK
LRIRVWEYKQ FTLNKLEGIY EEPLLSFAVG EIYNETTLYK FIKDSRVKRC RLYFQLYFQE
LYDFELSFLN WSFSDLLSSS YIQAKSYNYL SNKNNVKKRY IDDTSCNIFP HMCKNFKRFH
KKKIYRKVRN YDIDKNFSFN TALSDDSDER KNKNDRTIKN LEKLFVRNLT LMQNIEENED
MSYKNLQNIN LPNPRVTITL SHTPKGHEGL NIISIEQKSI RFPIWENLGE IYFRGTLRDL
DVSYLNIKVE DMSAPKSARE IGTCQISLKG IVDYPYVMHE LEAPSWLVKE AKYEGWENKL
NEWKLGTVEG KVIINRVPRY RQRGDIYHID AKQPYLIVHI FNIDKIITVD NIKELDTYVE
VSFDETSRRT RLMKKTLSPN YDSQISIPLR FNNKNDINYE NLSKKGLIYI DVWGKSEDIV
YIGGISISPY EIFFNEKNVR RNKTKLEHID LETNVKITYD TVVYRGCKKL CFLHDDQRMS
NIHFSIWTYP DILGNSTNQK KIVAPVSFNT TMNFPIKLAE KYNKLKKLFM EVLKTIKSIP
ENCTDVNTST RFYNYELINQ RKEKHFLPTL ITSIKSPYCA ESMNAIFHYV RCIPFIHKKE
NIIFTPDFTL QLKGGNALDH SLLLCSLFLG IPVLAFVCFG TLWDKQKHSW VATFEYNDEK
NYGIVKFWET TTGNVYILKK RFIDHNRLKG LELKLKESKY KSHLRNGFLQ RYENNTDIKY
IKEQTKRHIK QLFKNRINDI PIGGPSLPYK TIDLIFNHKN IYVNLQHSSP LNIWYDYWKF
DFWFPFSSIE YNLQPSFTIK SFTHKMEDME LDKIAKELRT NIEKNINIYR ASRNLSTRWN
RDETLEIFLQ VGLELLHQLN TSRKEDVLLA KLKIEDWKKA LYHKVPQSHR LLGFPYHFNT
YKSKFISDKL ISTLAILESR DRSLCLSLAV CLYSLPGNFI SCYIYIITCV KITQRELRKM
EIIKEKAQRM AEIKNSQKKK KSSDDQNIDI KTMDDVEEKE TFSSTNLDDT LHDEHTDIDT
EKKKHEKDNY KNKKIKNTKL KDANIDNEEK DDHHHITDKK VSKSSDLIHS FDKNDISKNT
FDKEEFINNL DKDKKYSSFK KGNVVNKKVS IKNEPSINIY EDHKIYDDEN ISNNIDNMEN
NQDEIYNLRQ GKTIINEFQQ VKKPQKYTIN EKRDDIKTKK KRSKEKKKQD KLEFEKLIQS
NAYFEQEKKK LQEDIKKLEK DKEQFQKEKI RREEKEKQLL LEEKIKLQKE KELFENEKLE
RKMSYMLKIN ELEKKKNERN KREESYKRMI QKDKEKKKKK ESRDKIRRGE EEKMKEQMKR
EKKMRREEKK KRVQEPIKID EIQVYDIIKN EKMKKKEEKE EKKRKKKKED IEDKYKIGKE
ASLDENNNER QIKSKNIQEI SDYEYKNIKE NKNLNKFDEK LDLNQIYSKA SNFYDNQEKK
RRTIKVHANR KENSDSTFSH IDDSIKNKKE YLEDSNIARY LYEKRKHDLI GKGNYNFDEP
HYGKKMNNVA YQDIKGSNLF KGFIEEPSSK KSPQKKKIVI VRKN
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