ID W4J1R8_PLAFP Unreviewed; 2946 AA.
AC W4J1R8;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=PHD-type domain-containing protein {ECO:0000259|PROSITE:PS50016};
GN ORFNames=PFUGPA_01816 {ECO:0000313|EMBL:ETW56155.1};
OS Plasmodium falciparum (isolate Palo Alto / Uganda).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=57270 {ECO:0000313|EMBL:ETW56155.1, ECO:0000313|Proteomes:UP000019103};
RN [1] {ECO:0000313|EMBL:ETW56155.1, ECO:0000313|Proteomes:UP000019103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW56155.1,
RC ECO:0000313|Proteomes:UP000019103};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum Palo Alto/Uganda.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW56155.1, ECO:0000313|Proteomes:UP000019103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW56155.1,
RC ECO:0000313|Proteomes:UP000019103};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Palo Alto/Uganda.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KI927327; ETW56155.1; -; Genomic_DNA.
DR EnsemblProtists; ETW56155; ETW56155; PFUGPA_01816.
DR OMA; CTYGYIK; -.
DR Proteomes; UP000019103; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.90.660.10; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002937; Amino_oxidase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10742:SF342; AMINO_OXIDASE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10742; FLAVIN MONOAMINE OXIDASE; 1.
DR Pfam; PF01593; Amino_oxidase; 1.
DR Pfam; PF13450; NAD_binding_8; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000019103};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 2838..2890
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 523..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 673..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1490..1510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1576..1651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1884..1907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1589..1606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1607..1643
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2946 AA; 348925 MW; 268108BC29ABB60D CRC64;
MGTEKEDDEQ DIVNRSNDLK KKKENNKCDN MSNDISDSIS NNISDSISTN ISNNISNNIS
NNISNNLSNN ISNNISNNLS NNISNNTSNN TSHNISHNIC HNISQNNHDI IKKVHIKNLN
IMNTHKDNNY KYKNNGLNIY NKKKKDYNGD ENLKINTRES YDIFYSYLKL SEKKSLKQSD
MIKDNMSEQD FFINVFSQKL KKHNIDLIMI NNKLYIYIKF SQDIDHLIPY FKREFFFKTL
IGNNIILLLA KKYEVTEVLI KSLYLKETIQ KFFTSNFTIE DFLVHNNFMN KYEIYRNIVI
NNFFPIQMNN KNGDHKKKKI NNNNNNNNKK KYIDHEDINN FVEYVHDLEE NQKYSSLPFE
KKCYKENIKC MKNFEKSHNM NKIQYVEDFQ KENTENGKIL YLKEKKGINK YNNEKDMMCN
HSAFDNNMVQ NNNVLDNNMC NKKNIKKKMK KNNVIKFMVD NYVINDVSNK MNHHNESLQE
NNNYSVLQIP NNNKQINNNI RANVILNNEF NLDVQKFRNT EETMNKIESN KNDKEERLQF
EKEKKQILKR EKKLRENQEK KRKQNQEKEN KKQEKIIKKK ELLILEKEIR KKLKEEKKLK
EKEEKKKEKE KFLKNEKEIK KKIKEDKKRQ KEEFLRKIKE EKKKLKEEKK KLKQEIINSI
KEERKKFKEL KSKFKKISKK DNHLNKDKKK TKQNKIDKSN QSNMNKKEYN NNDKKKDDIN
YQFLTDQINN NTVDKKKRKK THDISLSIKK KKKCTKNNLL LNSIDDIKSD SLSFISTFPT
FNNIEKEQED RNEINDILKL IEIKKVVNTQ EKNDYIECLH KSKSKNVKRN KDKIKQNQLL
SKGNNKIITK NGEHMNDQSD PLNQINSDLL NIDDFLINNM NTIIKKYKKG DTSNVDMSNV
DISNVDFSNK DISNKDISYV DISKKNVVHT NNSLHNIDNI HYNKNMNNSE RHNESEINEL
ILKGLKSFGD IKNLKSLQKI LRIKESKGKN KIETVVHIPN NVIERSVAKK IVLNKHEGIK
NKDGVKEKVK TKKKISLFGI VKPEDIIKRG INNVYHNIED NQKLYTDVLI IGAGISGLAA
SYYLNKCNAK FLVIEGRNRI GGRAFSTILP ERIINNKVLP ETVVDLGANY LHCCDNADLT
NDKKGKTKHE FANCTEFNNE KSMRKEDDID YEDNFIWNMK KKKTKKKKYK VIVKKRKYNY
NKDNGNDKNK MGNFSIYDVQ KEYVTNINLF KEEYSKLIND FAYLPYFEYL NNSLQSEHNQ
DDENKTGDKN KISGGNKNIY RYLNSNKNIS CNSNIYNNQR YYSDEDYFYS RRIKNRRKIK
LRNNMLFMIK NNIDNIRNYF KIYNKEKKDN ILNFFKSLDE DIHFYNNLSD SCVHTSSVLY
PKNNCTNKSN KLLKILSFNK DTRRRREYDK SVTQLAEKLK PRVSLVCGKD NWESTFYAHW
YNNENGKKIK SFKIYRVNLL CDKIRVRAAR KMRNFLFIGD SCNDEYQKDI KSEDQQKSNN
NYVSDDTNEK DSDYFYNNDI LKEDKQINNN ILIDDTYHKE ILFNNNHVKN IKPNENNIIR
NENFEASVLY NNKDDMKLDN EENGKNAENG KNEQNGENGK NAENGKNEQN EQNEENGKNG
KNEENGKNGK NEQNKNNEKT SKKHIISSKK KMSKVDMNNI LSYDNHAIIY NNYYDYGDLY
NKVVRNVSST NRNIDDEERK EKKKKEDISK TELYYNNKKR RSMWDLLMEC TEEIFTEMNI
NEENFTMEEW KMLMVTLQSR YGYGSDLRET SIAMSRLPFS NYLDIDMCPK YGSNNYILKN
IKYYDKIKKN EQTPYISSFK DLNTSDKIVV DGWKWLINYL SEEVQNKIFL NTVAELVYIK
DKHQDKKIYH LDNDNCQINK QKSSSFLNTK KKKNNNNNNN NNIESVENNS INSDHVINQD
NNSFVPQNEV SSKNKKKYIN ENFLINNVIK DDYKLGENNE DDYKVMIKCK CYDTKFKNIN
KHFHGTSDLN NCNYKNVTIY AKYVIVALPL GCLIENDKKR KLKTCLKFEP ELHPLKLRAL
QNYKMGNHNK IILRFYPYNF TWPFDSLQIN CIDQKFQFLN LHAYGKIGCI LVHCFPPWSC
TYGYIKKEHY IINECLYTLN KMFEKSGKKL PILVDYIITK WQDDNFSFGS YAYPYINCND
NDLIYLRSPH PINNPRVVFC GEYLSKSYFQ CVDGAYDTGI RAAEDIAHIG LHLKNNDTKN
YKTDVYIFPQ NKCPFTNIPL PPIKKKFLGF YITDGSDEAL TDYESSSDEN MNTNVDINID
INSNTNIDIN NNTNSNTSSN NNNTNKYNYC NNNIPISVMK KEYEFLLYSL QSIQNIFRFL
KKQNTHKNFK QDKNINHIKN ETDALKCSSY KKEIKSNTYE SFTNNSLINF EDKKSNDVKS
NISTLLLNLY EYNNKSTDQI HYFDRIKSID SYKSKYKNGS YLLELHSKDS ENDSNKNDAN
NICTIETFNN VDKNNKGDHI NDVHNDVYND VYNDKYTSNY NIETYSHITN NHFEYINNIS
NLYINKYMIK LNDAVFYNYN EIENTILNKQ HNAEYNKSYF VLLQTFSNIF KKYSDFTYFI
QKELFLKIQA MKHILFNDNN FQSLQDMNVV LSQAEHKNDH IVSHNNHMND VDRKKAYEQN
TDIINEDDKE ISYFHEKMEE VNNMNKMKLS LNLIKSNMVG NNNDDDNNNN NGHIQKSNIS
TDELDINKIN LNSKTKNNNI TNKKDVMIQT NLNIYNNIDL QNKIKNIYIN NRKICYLNDY
LKYVLIHLSI SKNILDEQIM SSNNNKWNSC GFLFFLCYIL QYILKHLKYD LFNSTVNTKV
VIQLLCDYIY YLIFCKHDIL CYKCMNGGEL NMCDSYNCNN SWHTYCLSSS EHNMNNKNDK
FWLCPSCSNI DISKHVQRGC YNQNEIMENY WKRRIYIYKI KFFLSRTRKI RKRLDLLKAH
LSRSVA
//
