ID W4J6T9_PLAFP Unreviewed; 932 AA.
AC W4J6T9;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Peptidase C1A papain C-terminal domain-containing protein {ECO:0000259|SMART:SM00645};
GN ORFNames=PFUGPA_00219 {ECO:0000313|EMBL:ETW57769.1};
OS Plasmodium falciparum (isolate Palo Alto / Uganda).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=57270 {ECO:0000313|EMBL:ETW57769.1, ECO:0000313|Proteomes:UP000019103};
RN [1] {ECO:0000313|EMBL:ETW57769.1, ECO:0000313|Proteomes:UP000019103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW57769.1,
RC ECO:0000313|Proteomes:UP000019103};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Hoffman S., Volkman S., Rosenthal P., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Allen A.W.,
RA Alvarado L., Arachchi H.M., Berlin A.M., Chapman S.B., Gainer-Dewar J.,
RA Goldberg J., Griggs A., Gujja S., Hansen M., Howarth C., Imamovic A.,
RA Ireland A., Larimer J., McCowan C., Murphy C., Pearson M., Poon T.W.,
RA Priest M., Roberts A., Saif S., Shea T., Sisk P., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "The Genome Annotation of Plasmodium falciparum Palo Alto/Uganda.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ETW57769.1, ECO:0000313|Proteomes:UP000019103}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Palo Alto/Uganda {ECO:0000313|EMBL:ETW57769.1,
RC ECO:0000313|Proteomes:UP000019103};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Neafsey D., Cheeseman I., Volkman S., Adams J., Walker B., Young S.K.,
RA Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L.,
RA Arachchi H.M., Berlin A.M., Chapman S.B., Dewar J., Goldberg J., Griggs A.,
RA Gujja S., Hansen M., Howarth C., Imamovic A., Larimer J., McCowan C.,
RA Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T.,
RA Sisk P., Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Plasmodium falciparum Palo Alto/Uganda.";
RL Submitted (FEB-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C1 family.
CC {ECO:0000256|ARBA:ARBA00008455}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KI927240; ETW57769.1; -; Genomic_DNA.
DR AlphaFoldDB; W4J6T9; -.
DR EnsemblProtists; ETW57769; ETW57769; PFUGPA_00219.
DR OMA; DEWNNCK; -.
DR Proteomes; UP000019103; Unassembled WGS sequence.
DR GO; GO:0008234; F:cysteine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd02619; Peptidase_C1; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR013128; Peptidase_C1A.
DR InterPro; IPR000668; Peptidase_C1A_C.
DR PANTHER; PTHR12411; CYSTEINE PROTEASE FAMILY C1-RELATED; 1.
DR PANTHER; PTHR12411:SF642; PRO-CATHEPSIN H; 1.
DR Pfam; PF00112; Peptidase_C1; 1.
DR SMART; SM00645; Pept_C1; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000019103};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 512..765
FT /note="Peptidase C1A papain C-terminal"
FT /evidence="ECO:0000259|SMART:SM00645"
FT REGION 33..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 821..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 821..841
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 932 AA; 105890 MW; A5AB417F7B41D4BB CRC64;
MLYIHIYIFY IYNLFHIGVL FCKNDIKCTT VDESTKEGSQ NPKNSSSTTP ASGSQKGSSS
ESPGSSVEKQ SQESNKESTN GGNVVSQGTP ANTFGQNSNN PSDSPQGTST LPSPPKSIDV
KSAFLKHYKG VKVTGSCNAN FQLFLVPHIF INVETKENNI QLDVKFLKLT KRIDFAKDKS
MLKNKCESGK NQTFKFVLYF KDDILTIKWK VYEEKSATPQ NTVDIKLYKL PKLDQPITSI
QVHTLSIEGT SYLMESKDYS LGNNLPEKCD AIASDCFLSG NINVEKCLKC TLKVKKVEAS
DECYKYVSKD KPKETKLAVS GSEVKEVKAA SVDHSNDKEY ELSQSINNIL NKMYKKESND
EKNNKKELIK LEDADDSLQK ELNKYCNSLK EVDLNGVLSK NEVGNEKDVF NNLTTLLKEH
MLESHHVVFE KLKNSALCLK NIDDWLKNKN GLIVPPSKYK LKDTNEKKEL NNNVEVIEDM
FKANEHGIVD LTKFPIDTNY LSYKHIDHTY CNNDYCNWSK DKNSCISKIN VEDQKNCALS
WAFASKYHLE TIKCMKGYEH IPISSLYIAN CSKNEKKDVC TEGSNPLKVL QMIVEKGFLP
TEGDYSYEQS KVGETCPEVQ NGWVNLWANA KLLEQNNDEH NSLSTKGYTA YESEAFQKDM
HSFVKLIKDE IMNKGSVIAY VKADKIMAYE FNGKKVQNLC GDKTPDHAVN IIGYGNYIND
EHQKKSYWIV RNSWGKHWGD KGHFKVDMYG PSDCEDNFIH SVVIFNVDLP INQESVKKEP
KIYNYYLKAS PDFYHNLYYK NFDSQKGKAD QAENKKSYLY GQEESTSEQL PSSLSSPQNN
KQSERSKEKV DIFHVLKHIK DSKIKMGIVK YDHSDALGED NVCSRSYSSN PEKQEGCVKF
CNENWGKCKD AASPGFCLSE LEKTNDCFFC YI
//
