ID W4LET6_9BACT Unreviewed; 743 AA.
AC W4LET6;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=protein-glutamate O-methyltransferase {ECO:0000256|ARBA:ARBA00012534};
DE EC=2.1.1.80 {ECO:0000256|ARBA:ARBA00012534};
DE Flags: Fragment;
GN ORFNames=ETSY2_47525 {ECO:0000313|EMBL:ETW95831.1};
OS Candidatus Entotheonella gemina.
OC Bacteria; Nitrospinae/Tectomicrobia group; Candidatus Tectomicrobia;
OC Entotheonella.
OX NCBI_TaxID=1429439 {ECO:0000313|EMBL:ETW95831.1, ECO:0000313|Proteomes:UP000019140};
RN [1] {ECO:0000313|EMBL:ETW95831.1, ECO:0000313|Proteomes:UP000019140}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSY2 {ECO:0000313|Proteomes:UP000019140};
RX PubMed=24476823; DOI=10.1038/nature12959;
RA Wilson M.C., Mori T., Ruckert C., Uria A.R., Helf M.J., Takada K.,
RA Gernert C., Steffens U.A., Heycke N., Schmitt S., Rinke C., Helfrich E.J.,
RA Brachmann A.O., Gurgui C., Wakimoto T., Kracht M., Crusemann M.,
RA Hentschel U., Abe I., Matsunaga S., Kalinowski J., Takeyama H., Piel J.;
RT "An environmental bacterial taxon with a large and distinct metabolic
RT repertoire.";
RL Nature 506:58-62(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-
CC glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:24452, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:10311,
CC ChEBI:CHEBI:29973, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:82795; EC=2.1.1.80;
CC Evidence={ECO:0000256|ARBA:ARBA00001541};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETW95831.1}.
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DR EMBL; AZHX01002265; ETW95831.1; -; Genomic_DNA.
DR AlphaFoldDB; W4LET6; -.
DR HOGENOM; CLU_000892_0_2_7; -.
DR Proteomes; UP000019140; Unassembled WGS sequence.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 1.10.155.10; Chemotaxis receptor methyltransferase CheR, N-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022642; CheR_C.
DR InterPro; IPR000780; CheR_MeTrfase.
DR InterPro; IPR022641; CheR_N.
DR InterPro; IPR036804; CheR_N_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR24422; CHEMOTAXIS PROTEIN METHYLTRANSFERASE; 1.
DR PANTHER; PTHR24422:SF25; CHEMOTAXIS PROTEIN METHYLTRANSFERASE; 1.
DR Pfam; PF01739; CheR; 1.
DR Pfam; PF03705; CheR_N; 1.
DR Pfam; PF13596; PAS_10; 1.
DR Pfam; PF13188; PAS_8; 1.
DR PRINTS; PR00996; CHERMTFRASE.
DR SMART; SM00138; MeTrc; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47757; Chemotaxis receptor methyltransferase CheR, N-terminal domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS50123; CHER; 1.
DR PROSITE; PS50113; PAC; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000019140};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 41..283
FT /note="CheR-type methyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50123"
FT DOMAIN 617..671
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT COILED 524..561
FT /evidence="ECO:0000256|SAM:Coils"
FT NON_TER 743
FT /evidence="ECO:0000313|EMBL:ETW95831.1"
SQ SEQUENCE 743 AA; 84599 MW; F9CA914F046D0AC1 CRC64;
MGQPRALHNT ACSEVNESEG VLDVASSVVK APDRISEKVP DKVIDELLAL LDCQVHTDFR
PYRRSMIVQR IERRMRQLNL QHVETYLQRC QSSPSEVRLL GREIFSGVTQ FFRDPEAFEY
LGNTAIPALI RKGASTGRIR IWVAGCATGE EAYSVAMLLR EKSDELASRP EVHIFATDVD
PQALEVADRG VYTESRIADI SPARVKRFFH RRGDHYQVIR SLRDMLIFAP HNLLEDPPLA
KMDLIVCRHV LIYMDTPFHA KILTPIQFAL QPNGFLFLGQ GESPGELAHL FQVLDAKWHV
YRKIHSLPLS GPAWMPPERS VRPLQHKAAN TESRRSGRHQ QLVERTVDHL LATYCPPTLL
INDQLEILHI IGDVSPYMKK LSGIPSFSVL QLLHDDLCLP IRTVLQRLKQ APEDILYHHV
PVRMAEGCRY LTLRGHREAF TDNSSDVIVL CLEAVEWGDH VRSAAPEQTA RTPEQERLEA
LEQMLRHAQE TLQATIGELE ASNLALQTGH EAISASNDAL LMANEELQAT NEELYTLNGE
YQNKIAELTR LTNDMDNLLR STEIGTIFLD TELRLRRFTP AIAESFHLLP RDIGRPLDHM
TSRLEDEQLL PDALQVLCTG VPIVQEVRKR PDRWMLRRLT PYRTEQGRCE GVVLTFVDVS
DLKTAEAMLQ RSEKRFRDLI EESVQGILIY RSGRPLFVNR ACAQLFGYAS PQDILALDDL
VADIAAPHEY TRLWHYTQRL LEG
//
