ID W4LK81_9BACT Unreviewed; 739 AA.
AC W4LK81;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Protein HflK {ECO:0000256|RuleBase:RU364113};
GN ORFNames=ETSY2_43025 {ECO:0000313|EMBL:ETW98299.1};
OS Candidatus Entotheonella gemina.
OC Bacteria; Nitrospinae/Tectomicrobia group; Candidatus Tectomicrobia;
OC Entotheonella.
OX NCBI_TaxID=1429439 {ECO:0000313|EMBL:ETW98299.1, ECO:0000313|Proteomes:UP000019140};
RN [1] {ECO:0000313|EMBL:ETW98299.1, ECO:0000313|Proteomes:UP000019140}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSY2 {ECO:0000313|Proteomes:UP000019140};
RX PubMed=24476823; DOI=10.1038/nature12959;
RA Wilson M.C., Mori T., Ruckert C., Uria A.R., Helf M.J., Takada K.,
RA Gernert C., Steffens U.A., Heycke N., Schmitt S., Rinke C., Helfrich E.J.,
RA Brachmann A.O., Gurgui C., Wakimoto T., Kracht M., Crusemann M.,
RA Hentschel U., Abe I., Matsunaga S., Kalinowski J., Takeyama H., Piel J.;
RT "An environmental bacterial taxon with a large and distinct metabolic
RT repertoire.";
RL Nature 506:58-62(2014).
CC -!- FUNCTION: HflC and HflK could encode or regulate a protease.
CC {ECO:0000256|RuleBase:RU364113}.
CC -!- SUBUNIT: HflC and HflK may interact to form a multimeric complex.
CC {ECO:0000256|RuleBase:RU364113}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the UPF0718 family.
CC {ECO:0000256|ARBA:ARBA00006386}.
CC -!- SIMILARITY: Belongs to the band 7/mec-2 family. HflK subfamily.
CC {ECO:0000256|ARBA:ARBA00006971, ECO:0000256|RuleBase:RU364113}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU364113}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETW98299.1}.
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DR EMBL; AZHX01001958; ETW98299.1; -; Genomic_DNA.
DR AlphaFoldDB; W4LK81; -.
DR PATRIC; fig|1429439.4.peg.7205; -.
DR HOGENOM; CLU_376288_0_0_7; -.
DR Proteomes; UP000019140; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd03404; SPFH_HflK; 1.
DR Gene3D; 3.30.479.30; Band 7 domain; 1.
DR InterPro; IPR001107; Band_7.
DR InterPro; IPR036013; Band_7/SPFH_dom_sf.
DR InterPro; IPR005524; DUF318.
DR InterPro; IPR010201; HflK.
DR NCBIfam; NF033936; CuZnOut_SO0444; 1.
DR NCBIfam; TIGR01933; hflK; 1.
DR PANTHER; PTHR34184; UPF0718 PROTEIN YCGR; 1.
DR PANTHER; PTHR34184:SF4; UPF0718 PROTEIN YCGR; 1.
DR Pfam; PF03773; ArsP_1; 1.
DR Pfam; PF01145; Band_7; 1.
DR SMART; SM00244; PHB; 1.
DR SUPFAM; SSF117892; Band 7/SPFH domain; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364113};
KW Reference proteome {ECO:0000313|Proteomes:UP000019140};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364113};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364113}.
FT TRANSMEM 37..53
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364113"
FT TRANSMEM 65..91
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364113"
FT TRANSMEM 213..232
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364113"
FT TRANSMEM 244..273
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364113"
FT TRANSMEM 279..300
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364113"
FT TRANSMEM 307..326
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364113"
FT TRANSMEM 346..365
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364113"
FT DOMAIN 412..611
FT /note="Band 7"
FT /evidence="ECO:0000259|SMART:SM00244"
FT REGION 719..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 739 AA; 80121 MW; 1A215CE7EF80A812 CRC64;
MPRRWNIAIL LIVALGLGVL FRDSVWAILI LAAESGPYLL IGFALAGFLK IIIPEQRVFK
YLGPNTFTSV ALASLLGIPI PLCSCSVLPV ATTLRQSGAS RGATTSFLIS TPETGLDSIG
ITYALLDPIM TIARPLAALT TAVVTGTLVT TLEQLGWAGE PGSSSLEADD GCDDHDHDHH
AGDIPSYATG WERIREITRR SLAYAFGPLM DDLTPWLILG FLISGLVVIA VPDNFFTLYV
PRGWAAYLLM LVIGTPIYIC AAAATPVAVA LIAKGLDPGA ALVLLLVGPA TNATTMLVIA
RLLGKRILAV HLIGVTGCAL LLGAILDELY PALGIDLSTA AAEVVHRGLS PIAAAAAAIL
IFFLVRSAIR IRLMPQVTQD IRRLGARFGV DPLSPGMRLT AVAVLGLAYV STAFSIIGPG
EAGWVMRFGR VVRTVSEPGL IIHLPLPFDR VERLQTRAVR RVELGFFRET DEDENALPWA
TAQSRDADDT PWVSMRRDFD AEAEMMTGEE NILSIQYAVH FDIRDPYAYR YRLADPDGLV
RSFASWVLRQ AVAQRAASDI LVVHRAALER ECHTILQREL DAMDSGIRVI AVTLQDVHAA
LPVHEAFRDV ASALEDKARR TRQAQGYRSE TLALARAEAY ALTQTAAGYQ SEVVNRARGQ
GQAFVSRLDA YRAHPALTRL RLYFETLETT LSDAQTTFLL GDDVVVELWK SRNGKGLPGD
MLQSVLPEPG GRRDSNPTK
//
