ID W4M2X8_9BACT Unreviewed; 317 AA.
AC W4M2X8;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=NAD-dependent dehydratase {ECO:0000313|EMBL:ETX04528.1};
GN ORFNames=ETSY2_28285 {ECO:0000313|EMBL:ETX04528.1};
OS Candidatus Entotheonella gemina.
OC Bacteria; Nitrospinae/Tectomicrobia group; Candidatus Tectomicrobia;
OC Entotheonella.
OX NCBI_TaxID=1429439 {ECO:0000313|EMBL:ETX04528.1, ECO:0000313|Proteomes:UP000019140};
RN [1] {ECO:0000313|EMBL:ETX04528.1, ECO:0000313|Proteomes:UP000019140}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSY2 {ECO:0000313|Proteomes:UP000019140};
RX PubMed=24476823; DOI=10.1038/nature12959;
RA Wilson M.C., Mori T., Ruckert C., Uria A.R., Helf M.J., Takada K.,
RA Gernert C., Steffens U.A., Heycke N., Schmitt S., Rinke C., Helfrich E.J.,
RA Brachmann A.O., Gurgui C., Wakimoto T., Kracht M., Crusemann M.,
RA Hentschel U., Abe I., Matsunaga S., Kalinowski J., Takeyama H., Piel J.;
RT "An environmental bacterial taxon with a large and distinct metabolic
RT repertoire.";
RL Nature 506:58-62(2014).
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETX04528.1}.
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DR EMBL; AZHX01001199; ETX04528.1; -; Genomic_DNA.
DR AlphaFoldDB; W4M2X8; -.
DR PATRIC; fig|1429439.4.peg.4798; -.
DR HOGENOM; CLU_007383_4_0_7; -.
DR UniPathway; UPA00796; UER00771.
DR Proteomes; UP000019140; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0048040; F:UDP-glucuronate decarboxylase activity; IEA:UniProtKB-EC.
DR GO; GO:0042732; P:D-xylose metabolic process; IEA:InterPro.
DR GO; GO:0033320; P:UDP-D-xylose biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05230; UGD_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR044516; UXS.
DR PANTHER; PTHR43078:SF6; UDP-GLUCURONIC ACID DECARBOXYLASE 1; 1.
DR PANTHER; PTHR43078; UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED; 1.
DR Pfam; PF01370; Epimerase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000019140}.
FT DOMAIN 9..243
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
SQ SEQUENCE 317 AA; 35890 MW; 49CFF0C0EF3C4A79 CRC64;
MSDYLRPRVL ITGGAGFLGS HLCEKLLYMG YEVLCVDNFY TGRRDNVIHL MDNPHFEVMR
HDICIPLYVE VDQIYNLACP ASPIHYQFDP VQTTKTSVHG SINMLGLAKR VKAKIMQAST
SEVYGDPIEH PQTEDYWGHV NPIGLRACYD EGKRCAETLF FDYYRQHGLQ IKVARVFNTY
GSRMHPNDGR VVSNFIVQAL SGEDITIYGD GLQTRSFCYV DDLIQGFVAL MQSPDDFTGP
VNLGNPTEIT MRDLAELILS MTDSSSRIVY KSLPVDDPIQ RRPDITRANA FLSWKPEIPL
ENGLEKTIAY FSDLLKA
//
