ID W4M3Z9_9BACT Unreviewed; 763 AA.
AC W4M3Z9;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=AAA domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=ETSY2_29330 {ECO:0000313|EMBL:ETX04342.1};
OS Candidatus Entotheonella gemina.
OC Bacteria; Nitrospinae/Tectomicrobia group; Candidatus Tectomicrobia;
OC Entotheonella.
OX NCBI_TaxID=1429439 {ECO:0000313|EMBL:ETX04342.1, ECO:0000313|Proteomes:UP000019140};
RN [1] {ECO:0000313|EMBL:ETX04342.1, ECO:0000313|Proteomes:UP000019140}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSY2 {ECO:0000313|Proteomes:UP000019140};
RX PubMed=24476823; DOI=10.1038/nature12959;
RA Wilson M.C., Mori T., Ruckert C., Uria A.R., Helf M.J., Takada K.,
RA Gernert C., Steffens U.A., Heycke N., Schmitt S., Rinke C., Helfrich E.J.,
RA Brachmann A.O., Gurgui C., Wakimoto T., Kracht M., Crusemann M.,
RA Hentschel U., Abe I., Matsunaga S., Kalinowski J., Takeyama H., Piel J.;
RT "An environmental bacterial taxon with a large and distinct metabolic
RT repertoire.";
RL Nature 506:58-62(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETX04342.1}.
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DR EMBL; AZHX01001243; ETX04342.1; -; Genomic_DNA.
DR AlphaFoldDB; W4M3Z9; -.
DR PATRIC; fig|1429439.4.peg.4974; -.
DR HOGENOM; CLU_009912_2_1_7; -.
DR Proteomes; UP000019140; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000019140};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 33..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 19..106
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 570..731
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
FT COILED 230..300
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 378..460
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 763 AA; 86173 MW; 6B9B2B1A790C1D3A CRC64;
MNFFRKLYQS LAVRAQKILD IHDYVGVCWR RKWLIILPLC LGACMAALYS YTVIPMYRSS
SLLIVEGQQI SKDYVPTASA SNLSERLGIL KQQILSRTNL ERVIRQFGLH RAQVLNETEP
EGWVDQIKSR VKTLLANAGF NVPKPVAVPD PEGIPERVVA QFRDRIEADV VGKRRRRKSS
YEAISVSFSG SNPHKVMGIT NAIARLFVEE NLRKGTQVVE GTTSFLNSQL TVAKQKLEQQ
EQLLKDFKER HMGALPEQMD ANLRKLDRLQ AELQSLNEAL LKAEEKKLLY QRELREVLSR
PAAVVEFNAP PADPRVERLK GLRQQLATLQ ARFTESYPDI PLLKNQIREL ESQLALTPPP
AASTTEPSPP VPRVNSLQQQ LEGQLRLVQR EVAGLKAQQR DIEATRKVYE DRIEQTFSNE
QQLNELNREI ESTRKNYREL EEKRNKAKLQ EELVKRQQGE RFDILDPAYL PLAPYKPNRK
EMVMFGAILG GAFGFGLAFF LDFLGRDSFR KPDEIQGAFQ VPLLASVPVN DVTRRQDQLV
TIEEPESIAS EQYRVLYTKI ERARQATSHK VIAISSAIPS DGKTISSLNL AVVMARDFGK
KTMLLEGDFK RPSLSSYLNT KLSGGLVDVL MDGPDGPPTL VPMADTLLPF AHDNLSILPA
VKSVRNSSHL LSSRRLQGLL DILKVQYDYI LIDTPPVLAL SDMNMYREVV DGIILVVRAE
VTPKRAVQQT LDMLGTDKVL GFVLNGVQQS FQPYYKYYGA ISA
//
