ID W4M557_9BACT Unreviewed; 660 AA.
AC W4M557;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Guanylate cyclase domain-containing protein {ECO:0000259|PROSITE:PS50125};
GN ORFNames=ETSY2_23765 {ECO:0000313|EMBL:ETX05298.1};
OS Candidatus Entotheonella gemina.
OC Bacteria; Nitrospinae/Tectomicrobia group; Candidatus Tectomicrobia;
OC Entotheonella.
OX NCBI_TaxID=1429439 {ECO:0000313|EMBL:ETX05298.1, ECO:0000313|Proteomes:UP000019140};
RN [1] {ECO:0000313|EMBL:ETX05298.1, ECO:0000313|Proteomes:UP000019140}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSY2 {ECO:0000313|Proteomes:UP000019140};
RX PubMed=24476823; DOI=10.1038/nature12959;
RA Wilson M.C., Mori T., Ruckert C., Uria A.R., Helf M.J., Takada K.,
RA Gernert C., Steffens U.A., Heycke N., Schmitt S., Rinke C., Helfrich E.J.,
RA Brachmann A.O., Gurgui C., Wakimoto T., Kracht M., Crusemann M.,
RA Hentschel U., Abe I., Matsunaga S., Kalinowski J., Takeyama H., Piel J.;
RT "An environmental bacterial taxon with a large and distinct metabolic
RT repertoire.";
RL Nature 506:58-62(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ETX05298.1}.
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DR EMBL; AZHX01000987; ETX05298.1; -; Genomic_DNA.
DR AlphaFoldDB; W4M557; -.
DR PATRIC; fig|1429439.4.peg.4041; -.
DR HOGENOM; CLU_480512_0_0_7; -.
DR Proteomes; UP000019140; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR Pfam; PF00520; Ion_trans; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000019140};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..35
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 41..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 503..540
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 660 AA; 73391 MW; 67ADD8C6CB630E4A CRC64;
MDTMERRLER FSLPVLILAG IAIVLYLLEL FRFIPASLHG VMLWVNFLID FVFLLDLSAK
IIILGTKYVK SPWFLIDLVS TLPIISSATE LLGSIGPQLQ STRVARGARV ARVARVARVA
RVARVARVAT ALRGVRGGFL KPPSEAQATP AFDRALFMTI PLLLIIFMAI SYFITQREVH
LLQTHLSRQV EIAATQADIA QFPEYLDAQQ AVNPQIDKIF ITKTIDAKRV KFAFSAAEAH
RRADLVQGLM LVFVLLTAAC VVHMSRSLTA DQKEEKEESL LSQFLSPAIV DKINTNPEVL
ERFYSRWLSV FFVAISGSTR AIGSESNDIE ALALLRRRVM DIVRQQTVVV HQGILDKFMG
DTVKGWIGGP FSAYWNRLSI FRERLALDEL EYVEQDIRSL TRAIEAIGPQ GNPELEGEAA
LGVASNDAER MAYLKEALSE VEANRIRLLE KHAAAQEEEP ALQARYEEAM HEYQKQTALS
AVLCCLGIWE EVSKQESEAA FHDLSIAIAS GPVSVGNFGS TDQIGFTVLG PTVDRAARLE
PASVQCGCRM LIDQATYDLV KKASELRFRL VPYISVSGTS EPIATYEPFK VEAVSEKFLE
AFHEGVFAMQ REALEEAVVH FKLADQLRDG GDTVSLMWIE ACQTAMREGS KIGIKLIEKS
//
