ID W4P3X4_9BACE Unreviewed; 734 AA.
AC W4P3X4;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=JCM6292_577 {ECO:0000313|EMBL:GAE14437.1};
OS Bacteroides pyogenes JCM 6292.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=1235809 {ECO:0000313|EMBL:GAE14437.1, ECO:0000313|Proteomes:UP000018861};
RN [1] {ECO:0000313|EMBL:GAE14437.1, ECO:0000313|Proteomes:UP000018861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 6292 {ECO:0000313|EMBL:GAE14437.1,
RC ECO:0000313|Proteomes:UP000018861};
RA Sakamoto M., Oshima K., Suda W., Kitamura K., Iida T., Hattori M.,
RA Ohkuma M.;
RT "Draft Genome Sequences of Three Strains of Bacteroides pyogenes Isolated
RT from a Cat and Swine.";
RL Genome Announc. 2:e01242-13(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAE14437.1}.
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DR EMBL; BAIQ01000004; GAE14437.1; -; Genomic_DNA.
DR AlphaFoldDB; W4P3X4; -.
DR Proteomes; UP000018861; Unassembled WGS sequence.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 1.10.10.1390; ATP-dependent DNA helicase RecQ; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR006293; DNA_helicase_ATP-dep_RecQ_bac.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR048671; RecQ-1-like_HTH.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR018982; RQC_domain.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR NCBIfam; TIGR01389; recQ; 1.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF21220; RecQ-1-like_HTH; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR Pfam; PF09382; RQC; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00341; HRDC; 1.
DR SMART; SM00956; RQC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:GAE14437.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 36..207
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 232..380
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 537..617
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
SQ SEQUENCE 734 AA; 82856 MW; E59C381399B79953 CRC64;
MNKSIYSKMA RNINLTEELK KHFGFDKFKG NQEAIVKNLL AGNDTFVLMP TGGGKSLCYQ
LPSLLMEGTA IVISPLIALM KNQVDAMRNF SEEDGVAHFI NSSLNKSAID QVKSDILAGK
TKLLYVAPES LTKDEYVEFL NSVKISFYAI DEAHCISEWG HDFRPEYRRI RPIINEIGKA
PVIALTATAT PKVQHDIQKN LAIVDAQVFK SSFNRPNLYY EVRAKTSNID KDIIKFIRNN
AEKSGIIYCL SRKKVEELAE ILQANGINAR AYHAGMDSAT RTQNQDDFLM EKVEVIVATI
AFGMGIDKPD VRFVIHYDIP KSLEGYYQET GRAGRDGGEG QCITFYTNKD LQKLEKFMQG
KPVAEQEIGK QLLLETAAYA ESSVCRRRSL LHYFGEEYTE DNCGNCDNCL NPKKQVEAQD
LLCSVIETII AVKENFKADY IIDILQGKET SEVQAHLHED LEVFGSGMGE EDRTWNAVIR
QALIAGYLSK DVENYGLLKV TPAGHKFLKK PTSFKITEDN DFEEAEEEAP TRAGGSCAVD
PVLYSMLKDL RKKLSKKLEV PPYVIFQDPS LEAMATIYPI TQEELQNIPG VGAGKAKRYG
EEFCKLIKRH CEENEIERPE DLRVRTVANK SKMKVSIIQA IDRKVALDDI ALSKGIEFGE
LLDEVEAIVY SGTKLNIDYF LEEIMDEDHM LDIYDYFKDS TTDNIDDALE ELGDEFTEEE
VRLVRIKFIS EMAN
//
