ID W4P9Z9_9BACE Unreviewed; 493 AA.
AC W4P9Z9;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=signal peptidase I {ECO:0000256|ARBA:ARBA00013208};
DE EC=3.4.21.89 {ECO:0000256|ARBA:ARBA00013208};
GN ORFNames=JCM6292_3034 {ECO:0000313|EMBL:GAE16582.1};
OS Bacteroides pyogenes JCM 6292.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=1235809 {ECO:0000313|EMBL:GAE16582.1, ECO:0000313|Proteomes:UP000018861};
RN [1] {ECO:0000313|EMBL:GAE16582.1, ECO:0000313|Proteomes:UP000018861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 6292 {ECO:0000313|EMBL:GAE16582.1,
RC ECO:0000313|Proteomes:UP000018861};
RA Sakamoto M., Oshima K., Suda W., Kitamura K., Iida T., Hattori M.,
RA Ohkuma M.;
RT "Draft Genome Sequences of Three Strains of Bacteroides pyogenes Isolated
RT from a Cat and Swine.";
RL Genome Announc. 2:e01242-13(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Cleavage of hydrophobic, N-terminal signal or leader sequences
CC from secreted and periplasmic proteins.; EC=3.4.21.89;
CC Evidence={ECO:0000256|ARBA:ARBA00000677};
CC -!- SIMILARITY: Belongs to the peptidase S26 family.
CC {ECO:0000256|ARBA:ARBA00009370}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAE16582.1}.
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DR EMBL; BAIQ01000038; GAE16582.1; -; Genomic_DNA.
DR AlphaFoldDB; W4P9Z9; -.
DR Proteomes; UP000018861; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR CDD; cd06530; S26_SPase_I; 1.
DR Gene3D; 2.10.109.10; Umud Fragment, subunit A; 2.
DR InterPro; IPR036286; LexA/Signal_pep-like_sf.
DR InterPro; IPR000223; Pept_S26A_signal_pept_1.
DR InterPro; IPR019758; Pept_S26A_signal_pept_1_CS.
DR InterPro; IPR019533; Peptidase_S26.
DR PANTHER; PTHR43390:SF1; CHLOROPLAST PROCESSING PEPTIDASE; 1.
DR PANTHER; PTHR43390; SIGNAL PEPTIDASE I; 1.
DR Pfam; PF10502; Peptidase_S26; 2.
DR PRINTS; PR00727; LEADERPTASE.
DR SUPFAM; SSF51306; LexA/Signal peptidase; 2.
DR PROSITE; PS00761; SPASE_I_3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 64..271
FT /note="Peptidase S26"
FT /evidence="ECO:0000259|Pfam:PF10502"
FT DOMAIN 435..469
FT /note="Peptidase S26"
FT /evidence="ECO:0000259|Pfam:PF10502"
FT ACT_SITE 94
FT /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
FT ACT_SITE 244
FT /evidence="ECO:0000256|PIRSR:PIRSR600223-1"
SQ SEQUENCE 493 AA; 57495 MW; BFCA512756D3506C CRC64;
MIQATRKQWI KFAIVTAIYL AFLIWVRSWW GLIVVPFIFD IYITKKIPWS FWRKSKNAAV
RTVMSWVDAI VFALVAVYFV NIYIFQNYQI PSSSLEKSLL VGDFLYVSKM SYGPRVPNTP
LSMPLAQHTL PIVNTKSYIE WPQWKYKRVA GFGRVKLNDI VVFNFPAGDT VALNNQQEDI
YAIAYQAGRS IYPKEVEMDS LTRNRQRDVY NLYYAAGRKY IDSNPRTFGK VVYRPVDRRE
NYVKRCVGLP GDTLEIVDGQ VMINGKATVN PENLQFNYFV QTTGPYIPEN MFRDLGISND
DRILIQNGGW DGELIAMGLD SRDSSGRLNP VYRLPLTKKM YDTLAGNKKL VGKIVKETDS
YDRKVYPLNL HNRWERNNYG PIWIPSKGAT ITLTDDNLPM YERCITAYEG NKLEVKADGF
YINGEKTDSY TFRMDYYWMM GDNRDNSLDS RYWGFVPEDH VVGKPIVVWL SLDKDRGWFD
GRIRWKRLFK WVH
//
