ID   W4QEW0_9BACI            Unreviewed;       355 AA.
AC   W4QEW0;
DT   19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT   19-MAR-2014, sequence version 1.
DT   24-JAN-2024, entry version 20.
DE   RecName: Full=L-lactate permease {ECO:0000256|RuleBase:RU365092};
GN   ORFNames=JCM9152_1266 {ECO:0000313|EMBL:GAE29879.1};
OS   Halalkalibacter hemicellulosilyticusJCM 9152.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Halalkalibacter.
OX   NCBI_TaxID=1236971 {ECO:0000313|EMBL:GAE29879.1, ECO:0000313|Proteomes:UP000018895};
RN   [1] {ECO:0000313|EMBL:GAE29879.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 9152 {ECO:0000313|EMBL:GAE29879.1};
RA   Yuki M., Oshima K., Suda W., Oshida Y., Kitamura K., Iida T., Hattori M.,
RA   Ohkuma M.;
RT   "Draft Genome Sequences of Three Alkaliphilic Bacillus Strains, Bacillus
RT   wakoensis JCM 9140T, Bacillus akibai JCM 9157T, and Bacillus
RT   hemicellulosilyticus JCM 9152T.";
RL   Genome Announc. 2:e01258-13(2014).
CC   -!- FUNCTION: Uptake of L-lactate across the membrane. Can also transport
CC       D-lactate and glycolate. {ECO:0000256|RuleBase:RU365092}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU365092};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU365092}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the lactate permease family.
CC       {ECO:0000256|ARBA:ARBA00010100, ECO:0000256|RuleBase:RU365092}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU365092}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAE29879.1}.
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DR   EMBL; BAUU01000007; GAE29879.1; -; Genomic_DNA.
DR   AlphaFoldDB; W4QEW0; -.
DR   STRING; 1236971.JCM9152_1266; -.
DR   Proteomes; UP000018895; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015129; F:lactate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   InterPro; IPR003804; Lactate_perm.
DR   PANTHER; PTHR30003:SF0; GLYCOLATE PERMEASE GLCA; 1.
DR   PANTHER; PTHR30003; L-LACTATE PERMEASE; 1.
DR   Pfam; PF02652; Lactate_perm; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW   ECO:0000256|RuleBase:RU365092};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365092};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018895};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU365092};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU365092};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU365092}.
FT   TRANSMEM        6..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        61..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        117..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        201..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        253..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        300..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
FT   TRANSMEM        329..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU365092"
SQ   SEQUENCE   355 AA;  39110 MW;  066144DBCAE31918 CRC64;
     MQIDVIIGTL MPLVLVMMLT RFFGKNRSWL EGLKVWKFAL FAGISFTFPA LLVATFVGPE
     FPSIFGGLIG LFIVLLAIKK GWFLPEEDWD FDKKEHWNKE WLGSIVLKTE EGHSRSLPLW
     LAWIPYLALG FLLVLTRLEV FPFKSWLEGV VIGWSNILGT SISATFSPLY LPGTIFLIVV
     ILTFFLHQMN RLMMVRAVKQ SSGMLIGSAV TLFTAVPMVR IFINSGVNNA ELVSMPIELA
     NQAAYYLGNS WPLVAPFIGA LGSFISGSAT FSNMMFSLLQ FSVADQLALP PERILALQVL
     GANAGNMICV LNVVAAASVV GLIGKEGTII RLTILPMLFY ASLAGVVGFL YILIF
//