ID W4QGE8_9BACI Unreviewed; 378 AA.
AC W4QGE8;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=glucose-6-phosphate isomerase {ECO:0000256|ARBA:ARBA00011952};
DE EC=5.3.1.9 {ECO:0000256|ARBA:ARBA00011952};
GN ORFNames=JCM9152_2417 {ECO:0000313|EMBL:GAE30982.1};
OS Halalkalibacter hemicellulosilyticusJCM 9152.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Halalkalibacter.
OX NCBI_TaxID=1236971 {ECO:0000313|EMBL:GAE30982.1, ECO:0000313|Proteomes:UP000018895};
RN [1] {ECO:0000313|EMBL:GAE30982.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 9152 {ECO:0000313|EMBL:GAE30982.1};
RA Yuki M., Oshima K., Suda W., Oshida Y., Kitamura K., Iida T., Hattori M.,
RA Ohkuma M.;
RT "Draft Genome Sequences of Three Alkaliphilic Bacillus Strains, Bacillus
RT wakoensis JCM 9140T, Bacillus akibai JCM 9157T, and Bacillus
RT hemicellulosilyticus JCM 9152T.";
RL Genome Announc. 2:e01258-13(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate;
CC Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57634, ChEBI:CHEBI:58225;
CC EC=5.3.1.9; Evidence={ECO:0000256|ARBA:ARBA00029321};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 2/4.
CC {ECO:0000256|ARBA:ARBA00004926}.
CC -!- SIMILARITY: Belongs to the archaeal-type GPI family.
CC {ECO:0000256|ARBA:ARBA00006542}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAE30982.1}.
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DR EMBL; BAUU01000015; GAE30982.1; -; Genomic_DNA.
DR RefSeq; WP_035344137.1; NZ_BAZO01000015.1.
DR AlphaFoldDB; W4QGE8; -.
DR STRING; 1236971.JCM9152_2417; -.
DR OrthoDB; 9801056at2; -.
DR UniPathway; UPA00109; UER00181.
DR Proteomes; UP000018895; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR CDD; cd07007; cupin_CapF-like_C; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR010551; G6P_isomerase_prok.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR011051; RmlC_Cupin_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF59; NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE; 1.
DR Pfam; PF01370; Epimerase; 1.
DR Pfam; PF06560; GPI; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF51182; RmlC-like cupins; 1.
PE 3: Inferred from homology;
KW Gluconeogenesis {ECO:0000256|ARBA:ARBA00022432};
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152};
KW Reference proteome {ECO:0000313|Proteomes:UP000018895}.
FT DOMAIN 6..183
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
FT DOMAIN 294..361
FT /note="Glucose-6-phosphate isomerase prokaryote"
FT /evidence="ECO:0000259|Pfam:PF06560"
SQ SEQUENCE 378 AA; 43655 MW; 0EC55A3BFD955514 CRC64;
MKNVNVLITG ANGFIGKNLY VALEEMKNVS IKTYTRDQTI KELEQFLNQA DVVFHLAGVN
RVKDEDIEFV EGNINLTEKI TGILRKIDRK PIIVMSSSIQ VTNNTPYGES KKKAEEILEK
YAQETNHNQV FIYRLTNVFG KWGKPNYNSV VATFCYNISR GLDVDIHDPL NEIELVYIDD
VIKEFKNRIY CLKEKSKPFI HQVTPTYKIT LKKLAAQIYE FYNLRKNLIM PDLSNPLTKA
LYSTYLSYLD QYQFAYNLEI KKDLRGSLVE LLKSDHFGQI FISTSHPGVI RGNHYHHTKV
EKFCVIKGKA NIKLQNIISD EISSYVVTGD KAQIVDIPPG YTHSLENIGE SELIVLFWAN
EIFDKDRPDT YFREVENE
//
