ID W4UZM3_9BACE Unreviewed; 800 AA.
AC W4UZM3;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=F5/8 type C domain-containing protein {ECO:0000259|PROSITE:PS50022};
GN ORFNames=JCM10512_4385 {ECO:0000313|EMBL:GAE85914.1};
OS Bacteroides reticulotermitis JCM 10512.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=1445607 {ECO:0000313|EMBL:GAE85914.1, ECO:0000313|Proteomes:UP000019131};
RN [1] {ECO:0000313|EMBL:GAE85914.1, ECO:0000313|Proteomes:UP000019131}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 10512 {ECO:0000313|EMBL:GAE85914.1,
RC ECO:0000313|Proteomes:UP000019131};
RA Yuki M., Oshima K., Suda W., Sakamoto M., Iida T., Hattori M., Ohkuma M.;
RT "Draft Genome Sequence of Bacteroides reticulotermitis Strain JCM 10512T,
RT Isolated from the Gut of a Termite.";
RL Genome Announc. 2:e00072-14(2014).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 43 family.
CC {ECO:0000256|ARBA:ARBA00009865}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAE85914.1}.
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DR EMBL; BAIV01000033; GAE85914.1; -; Genomic_DNA.
DR RefSeq; WP_044164966.1; NZ_BAIV01000033.1.
DR AlphaFoldDB; W4UZM3; -.
DR STRING; 1445607.JCM10512_4385; -.
DR OrthoDB; 3308423at2; -.
DR Proteomes; UP000019131; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR CDD; cd18608; GH43_F5-8_typeC-like; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR006710; Glyco_hydro_43.
DR InterPro; IPR023296; Glyco_hydro_beta-prop_sf.
DR PANTHER; PTHR43772:SF2; BETA-1,4-XYLOSIDASE (EUROFUNG); 1.
DR PANTHER; PTHR43772; ENDO-1,4-BETA-XYLANASE; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF04616; Glyco_hydro_43; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR SUPFAM; SSF75005; Arabinanase/levansucrase/invertase; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS50022; FA58C_3; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Polysaccharide degradation {ECO:0000256|ARBA:ARBA00022651};
KW Reference proteome {ECO:0000313|Proteomes:UP000019131};
KW Signal {ECO:0000256|SAM:SignalP};
KW Xylan degradation {ECO:0000256|ARBA:ARBA00022651}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..800
FT /note="F5/8 type C domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004851637"
FT DOMAIN 317..456
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT ACT_SITE 40
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT ACT_SITE 203
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT SITE 149
FT /note="Important for catalytic activity, responsible for
FT pKa modulation of the active site Glu and correct
FT orientation of both the proton donor and substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-2"
SQ SEQUENCE 800 AA; 89772 MW; 31187EFDB20980C3 CRC64;
MNRLYFWLAA LLCGTVSVLA QASFDTPGTG NPVIPGYFAD PTVKKFGDTY YIYATTDGSG
AGFGPAQVWT SKDFANWTLM PMNWPDSHWI WAPDVMRHSD GKYYYFYCQP CIIHCGVSDT
PRGPWKNILG ESEAVLIPDR FVTNAITLDG QTFVDDDGSV YMYWGTWGIY KGFGCGAGKM
TSDLKGFSKT RLIPNTEATD FFEAPFVIKR NGIYYFMYSS GSCHDQTYRV QYATSDAPLG
PYKYGGCILE TSADGTIHGP GHHSILQEGD NYYIVYHRHD NPHANRGFHR QVCIDRMTFD
AEGNIQKIIP THDGVGALAP STVQSKNLAY QKTVRASSFY DDNFRPELAV DDNNGTLWRP
RGMGQEWIEI DLGSNQQIQT IWTQFQYGTQ FYQYLIETSV NGKQWSVFAD KRNNHLAGSP
MVDFGKTKAR YVRLTFTGGQ KNGFGGAIWN IKVFGGIEAS APQQWLGLTA ADWNGREWEN
NEGMLGGSFK LKQGAARTQR IAGRDALVLE PGTTLEFLHP LLSPSTEHTL SVLVYRLGKW
QSDEVKSSLS NGKILLQSGA EPLIITNLRY YNWVQEEAEK AFDATMDIVR LPAANLQKKG
LVVSITADAF SLGDTVQYIP NNGVKGIFEG IKAPSIVEET AGKKGFRFDG SQVFRSNFQL
PTTLLDNAPY TLEAWVLNPT IDLNECVADF TTSHDELEKI MLVNGTEPRC GVINHYGWYE
DAGYKNLNEW AGKWQHIYIC FDGRIEQVYV NDQLVSEKDI QLLIKPSQFV TLGLNAEGNW
PFTGYLHSLK LWDEYLPKLK
//
