ID W4VPW2_9BACI Unreviewed; 298 AA.
AC W4VPW2;
DT 19-MAR-2014, integrated into UniProtKB/TrEMBL.
DT 19-MAR-2014, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=2-hydroxy-3-oxopropionate reductase {ECO:0000313|EMBL:GAE95400.1};
GN ORFNames=JCM21714_4636 {ECO:0000313|EMBL:GAE95400.1};
OS Gracilibacillus boraciitolerans JCM 21714.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Gracilibacillus.
OX NCBI_TaxID=1298598 {ECO:0000313|EMBL:GAE95400.1, ECO:0000313|Proteomes:UP000019102};
RN [1] {ECO:0000313|EMBL:GAE95400.1, ECO:0000313|Proteomes:UP000019102}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 21714 {ECO:0000313|EMBL:GAE95400.1,
RC ECO:0000313|Proteomes:UP000019102};
RA Ahmed I., Oshima K., Suda W., Kitamura K., Iida T., Ohmori Y., Fujiwara T.,
RA Hattori M., Ohkuma M.;
RT "Draft Genome Sequence of the Boron-Tolerant and Moderately Halotolerant
RT Bacterium Gracilibacillus boraciitolerans JCM 21714T.";
RL Genome Announc. 2:e00097-14(2014).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAE95400.1}.
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DR EMBL; BAVS01000056; GAE95400.1; -; Genomic_DNA.
DR AlphaFoldDB; W4VPW2; -.
DR STRING; 1298598.JCM21714_4636; -.
DR eggNOG; COG2084; Bacteria.
DR OrthoDB; 9786703at2; -.
DR Proteomes; UP000019102; Unassembled WGS sequence.
DR GO; GO:0008679; F:2-hydroxy-3-oxopropionate reductase activity; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0046487; P:glyoxylate metabolic process; IEA:InterPro.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006398; Tartro_sem_red.
DR NCBIfam; TIGR01505; tartro_sem_red; 1.
DR PANTHER; PTHR43060:SF3; 2-HYDROXY-3-OXOPROPIONATE REDUCTASE; 1.
DR PANTHER; PTHR43060; 3-HYDROXYISOBUTYRATE DEHYDROGENASE-LIKE 1, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000019102}.
FT DOMAIN 2..161
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 164..284
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 170
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 298 AA; 31851 MW; 8C1EA408E9AE4A93 CRC64;
MKIGFIGLGI MGKPMAFNLL KNNFELKAFD LNENARKEVV EKGGMEVFSS QEATEGSDVL
ITMLPTSGII ENVLFGKDGV SKSLKKDAVV INMSSVSPVE SVKWAERLNE NGVEYLDAPV
SGGEPKAIDG TLAIMVGGKE EVFNKTLPIL EAMGEEITLV GGIGSGSTTK LANQILVNVT
IAAIGEAVVL ASKAGVDIEK MYQAIRGGLA GSTVLDAKMP LIIERNFKPG GRIEINLKDL
LNVQATGREL QTPLPLTTNV IEMFQSLKAH GKQTDDHSGL IQYYEQVANY QVPKGGSK
//